ENSG00000187187

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347077 ENSG00000187187 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF546 protein_coding protein_coding 1.111758 0.2138985 1.670221 0.01187392 0.2575296 2.907734 0.05880509 0.09306767 0.02752779 0.02704648 0.02752779 -1.4575605 0.08605417 0.4485333 0.02236667 -0.42616667 0.00954345 0.00954345 FALSE TRUE
ENST00000597363 ENSG00000187187 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF546 protein_coding processed_transcript 1.111758 0.2138985 1.670221 0.01187392 0.2575296 2.907734 0.05046538 0.04044621 0.05933652 0.04044621 0.02966859 0.4588696 0.06353333 0.1737667 0.03186667 -0.14190000 0.55750677 0.00954345   FALSE
ENST00000599504 ENSG00000187187 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF546 protein_coding protein_coding 1.111758 0.2138985 1.670221 0.01187392 0.2575296 2.907734 0.51984581 0.05624419 0.83877072 0.02877429 0.02827006 3.6795091 0.41593333 0.2740000 0.52456667 0.25056667 0.36252858 0.00954345 FALSE TRUE
ENST00000600094 ENSG00000187187 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF546 protein_coding protein_coding 1.111758 0.2138985 1.670221 0.01187392 0.2575296 2.907734 0.19174612 0.00000000 0.44168223 0.00000000 0.08529776 5.4972362 0.15917917 0.0000000 0.26110000 0.26110000 0.01867083 0.00954345 FALSE TRUE
ENST00000601138 ENSG00000187187 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF546 protein_coding protein_coding 1.111758 0.2138985 1.670221 0.01187392 0.2575296 2.907734 0.13914372 0.00000000 0.18062628 0.00000000 0.18062628 4.2526751 0.11446667 0.0000000 0.08510000 0.08510000 1.00000000 0.00954345 FALSE FALSE
ENST00000602253 ENSG00000187187 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF546 protein_coding retained_intron 1.111758 0.2138985 1.670221 0.01187392 0.2575296 2.907734 0.08207239 0.00000000 0.09458452 0.00000000 0.09458452 3.3865974 0.07402500 0.0000000 0.05706667 0.05706667 1.00000000 0.00954345   FALSE
ENST00000651981 ENSG00000187187 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF546 protein_coding nonsense_mediated_decay 1.111758 0.2138985 1.670221 0.01187392 0.2575296 2.907734 0.06497725 0.02414043 0.02769273 0.02414043 0.01387924 0.1428048 0.08382083 0.1037000 0.01796667 -0.08573333 0.43153238 0.00954345 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187187 E001 0.1451727 0.0435270868 1.000000000   19 39984134 39984271 138 + 0.057 0.000 -8.331
ENSG00000187187 E002 0.0000000       19 39993410 39993571 162 +      
ENSG00000187187 E003 0.5953508 0.0292889556 0.117448946 0.21631264 19 39994814 39994991 178 + 0.108 0.397 2.400
ENSG00000187187 E004 0.0000000       19 39997036 39997037 2 +      
ENSG00000187187 E005 0.0000000       19 39997038 39997059 22 +      
ENSG00000187187 E006 0.0000000       19 39997060 39997062 3 +      
ENSG00000187187 E007 3.2665760 0.0063440199 0.092752512 0.17942558 19 39997063 39997119 57 + 0.599 0.243 -1.987
ENSG00000187187 E008 4.5983875 0.0036155063 0.020915709 0.05341266 19 39997120 39997157 38 + 0.719 0.243 -2.502
ENSG00000187187 E009 0.1817044 0.0410259622 0.073520201   19 39997236 39997269 34 + 0.000 0.243 12.703
ENSG00000187187 E010 4.9294292 0.0043538493 0.531439480 0.66389037 19 39997861 39997915 55 + 0.708 0.601 -0.454
ENSG00000187187 E011 2.8453247 0.0054558270 0.486200785 0.62400434 19 39998248 39998332 85 + 0.474 0.602 0.599
ENSG00000187187 E012 0.8438645 0.0147150336 0.026334106 0.06461742 19 39998333 39998410 78 + 0.108 0.512 2.991
ENSG00000187187 E013 0.2924217 0.0305706834 1.000000000   19 39998411 39998550 140 + 0.108 0.000 -11.012
ENSG00000187187 E014 0.1482932 0.0428017197 0.073962853   19 39999601 39999670 70 + 0.000 0.242 12.694
ENSG00000187187 E015 0.4427912 0.2934824509 0.471083181 0.61022424 19 39999671 39999854 184 + 0.108 0.240 1.384
ENSG00000187187 E016 4.4426056 0.0037034025 0.024585152 0.06102144 19 40006096 40006182 87 + 0.708 0.243 -2.453
ENSG00000187187 E017 4.9971543 0.0033526545 0.668733119 0.77567523 19 40007274 40007400 127 + 0.670 0.740 0.291
ENSG00000187187 E018 3.9826430 0.0062282750 0.299383867 0.44089338 19 40008470 40008565 96 + 0.567 0.740 0.744
ENSG00000187187 E019 0.0000000       19 40011251 40011348 98 +      
ENSG00000187187 E020 49.7992928 0.0013508828 0.033145471 0.07809504 19 40013665 40016427 2763 + 1.613 1.502 -0.380
ENSG00000187187 E021 33.0777119 0.0007950255 0.006058487 0.01876379 19 40016428 40021038 4611 + 1.391 1.559 0.576