ENSG00000187164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392903 ENSG00000187164 HEK293_OSMI2_2hA HEK293_TMG_2hB SHTN1 protein_coding protein_coding 9.05805 5.980802 12.76138 0.400297 0.4506315 1.092094 0.8377005 0.22841502 1.818980 0.03720432 0.1583060 2.9394924 0.07937917 0.03896667 0.14220000 0.10323333 3.422449e-05 3.422449e-05 FALSE TRUE
ENST00000497044 ENSG00000187164 HEK293_OSMI2_2hA HEK293_TMG_2hB SHTN1 protein_coding processed_transcript 9.05805 5.980802 12.76138 0.400297 0.4506315 1.092094 5.4225005 4.38441691 6.669720 0.41375692 0.1644834 0.6041159 0.62450000 0.73020000 0.52386667 -0.20633333 1.815250e-04 3.422449e-05 FALSE TRUE
MSTRG.4699.10 ENSG00000187164 HEK293_OSMI2_2hA HEK293_TMG_2hB SHTN1 protein_coding   9.05805 5.980802 12.76138 0.400297 0.4506315 1.092094 0.7571584 0.39723393 1.258074 0.06380856 0.1664225 1.6387098 0.07329583 0.06553333 0.09906667 0.03353333 3.879807e-01 3.422449e-05 FALSE TRUE
MSTRG.4699.7 ENSG00000187164 HEK293_OSMI2_2hA HEK293_TMG_2hB SHTN1 protein_coding   9.05805 5.980802 12.76138 0.400297 0.4506315 1.092094 0.7354977 0.07975367 1.316803 0.07975367 0.4258713 3.8858395 0.06734167 0.01226667 0.10256667 0.09030000 6.569263e-02 3.422449e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187164 E001 0.0000000       10 116881477 116881481 5 -      
ENSG00000187164 E002 0.9683114 0.0186433414 4.427756e-01 5.843394e-01 10 116881482 116881558 77 - 0.232 0.371 0.929
ENSG00000187164 E003 1.2972648 0.0105426637 3.727908e-01 5.172108e-01 10 116881559 116881595 37 - 0.288 0.447 0.932
ENSG00000187164 E004 2.8773098 0.0399031246 3.846599e-03 1.271175e-02 10 116881596 116881805 210 - 0.338 0.831 2.294
ENSG00000187164 E005 15.8135554 0.0012587757 3.474234e-02 8.115308e-02 10 116881806 116883376 1571 - 1.137 1.318 0.637
ENSG00000187164 E006 29.4400537 0.0172931653 2.314535e-01 3.642116e-01 10 116883377 116884196 820 - 1.427 1.531 0.358
ENSG00000187164 E007 7.6632612 0.0362492024 4.582943e-01 5.986313e-01 10 116884197 116884314 118 - 0.893 0.996 0.383
ENSG00000187164 E008 15.3331949 0.0013365335 9.571880e-01 9.771805e-01 10 116884315 116884796 482 - 1.206 1.212 0.020
ENSG00000187164 E009 362.6395126 0.0004149841 2.257780e-33 4.899538e-31 10 116884797 116886373 1577 - 2.450 2.667 0.724
ENSG00000187164 E010 103.3692522 0.0003455119 3.620539e-01 5.064551e-01 10 116886374 116886566 193 - 2.016 1.984 -0.106
ENSG00000187164 E011 8.7456521 0.0089744008 5.569380e-02 1.191721e-01 10 116889195 116889279 85 - 1.046 0.807 -0.903
ENSG00000187164 E012 11.6808042 0.0107385472 1.426488e-01 2.516402e-01 10 116900312 116900540 229 - 1.145 0.981 -0.597
ENSG00000187164 E013 12.6685937 0.0113047720 5.912853e-01 7.140767e-01 10 116901390 116901679 290 - 1.145 1.088 -0.203
ENSG00000187164 E014 94.0316444 0.0007587299 4.197882e-01 5.630513e-01 10 116901765 116901957 193 - 1.980 1.950 -0.100
ENSG00000187164 E015 73.6638375 0.0003801207 2.503285e-01 3.863273e-01 10 116906627 116906747 121 - 1.880 1.833 -0.161
ENSG00000187164 E016 55.5249679 0.0004163954 6.697520e-01 7.764234e-01 10 116911790 116911843 54 - 1.749 1.729 -0.067
ENSG00000187164 E017 72.8476864 0.0004046621 8.987148e-01 9.394004e-01 10 116915375 116915484 110 - 1.859 1.855 -0.015
ENSG00000187164 E018 48.9561102 0.0038645942 7.901115e-01 8.657541e-01 10 116921434 116921516 83 - 1.691 1.676 -0.050
ENSG00000187164 E019 44.3775226 0.0005916907 4.573174e-01 5.976560e-01 10 116927792 116927891 100 - 1.630 1.671 0.138
ENSG00000187164 E020 58.4980877 0.0055653917 4.010819e-01 5.447607e-01 10 116929849 116930002 154 - 1.779 1.731 -0.164
ENSG00000187164 E021 64.6190286 0.0003745590 3.090000e-01 4.512868e-01 10 116940466 116940612 147 - 1.820 1.774 -0.153
ENSG00000187164 E022 63.5418136 0.0004412473 1.831208e-01 3.051106e-01 10 116944924 116945018 95 - 1.818 1.758 -0.204
ENSG00000187164 E023 53.2520519 0.0004304327 1.350100e-02 3.707974e-02 10 116948916 116948997 82 - 1.765 1.641 -0.421
ENSG00000187164 E024 58.9469910 0.0004307350 1.410806e-05 9.051509e-05 10 116951909 116952006 98 - 1.836 1.623 -0.724
ENSG00000187164 E025 30.6125726 0.0014114404 2.695921e-02 6.590883e-02 10 116954042 116954048 7 - 1.537 1.387 -0.515
ENSG00000187164 E026 65.6588833 0.0055080285 2.518807e-04 1.183102e-03 10 116954049 116954210 162 - 1.880 1.669 -0.716
ENSG00000187164 E027 48.6151094 0.0189434617 1.405470e-01 2.487896e-01 10 116960136 116960230 95 - 1.722 1.606 -0.396
ENSG00000187164 E028 0.0000000       10 116960231 116960331 101 -      
ENSG00000187164 E029 42.8830977 0.0022085034 5.026885e-02 1.096394e-01 10 116968652 116968712 61 - 1.669 1.552 -0.397
ENSG00000187164 E030 0.0000000       10 116973856 116974170 315 -      
ENSG00000187164 E031 39.5227210 0.0086263372 1.630707e-03 6.059520e-03 10 116979256 116979308 53 - 1.675 1.439 -0.807
ENSG00000187164 E032 46.7900979 0.0004910709 2.395216e-05 1.459525e-04 10 117005022 117005577 556 - 1.745 1.512 -0.796
ENSG00000187164 E033 0.0000000       10 117048445 117048510 66 -      
ENSG00000187164 E034 0.0000000       10 117126307 117126586 280 -