ENSG00000187147

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000471494 ENSG00000187147 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF220 protein_coding processed_transcript 85.31816 122.4784 64.52767 2.849839 2.050481 -0.9244318 5.339722 1.908557 6.002062 1.908557 0.5678560 1.6478381 0.06372917 0.01496667 0.09300000 0.078033333 0.069503698 0.002192386 FALSE FALSE
ENST00000475378 ENSG00000187147 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF220 protein_coding processed_transcript 85.31816 122.4784 64.52767 2.849839 2.050481 -0.9244318 41.191420 67.616653 25.568600 1.290484 2.7235713 -1.4026547 0.47442083 0.55243333 0.39443333 -0.158000000 0.002192386 0.002192386 FALSE TRUE
ENST00000497469 ENSG00000187147 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF220 protein_coding processed_transcript 85.31816 122.4784 64.52767 2.849839 2.050481 -0.9244318 6.708440 8.434054 4.375150 1.864257 0.6712992 -0.9453096 0.08422500 0.06956667 0.06833333 -0.001233333 1.000000000 0.002192386 FALSE FALSE
MSTRG.1050.10 ENSG00000187147 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF220 protein_coding   85.31816 122.4784 64.52767 2.849839 2.050481 -0.9244318 9.060908 11.250832 8.894218 1.287993 1.4750911 -0.3387525 0.10410417 0.09163333 0.13950000 0.047866667 0.390112632 0.002192386 FALSE TRUE
MSTRG.1050.14 ENSG00000187147 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF220 protein_coding   85.31816 122.4784 64.52767 2.849839 2.050481 -0.9244318 7.161602 11.380953 6.112185 1.458623 0.9588872 -0.8957699 0.08104583 0.09263333 0.09583333 0.003200000 1.000000000 0.002192386 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187147 E001 2.3584219 6.451638e-03 4.031915e-01 5.469711e-01 1 44405143 44405193 51 + 0.582 0.448 -0.646
ENSG00000187147 E002 9.3280663 1.835565e-03 3.429300e-01 4.869656e-01 1 44405194 44405254 61 + 1.036 0.938 -0.366
ENSG00000187147 E003 11.6768477 1.541810e-03 6.320233e-01 7.469567e-01 1 44405255 44405287 33 + 1.089 1.047 -0.154
ENSG00000187147 E004 24.3082521 8.208336e-04 1.724543e-01 2.913954e-01 1 44405288 44405526 239 + 1.421 1.328 -0.324
ENSG00000187147 E005 1.0695761 1.258412e-02 9.473219e-01 9.709070e-01 1 44405527 44405530 4 + 0.288 0.279 -0.060
ENSG00000187147 E006 0.0000000       1 44408702 44408908 207 +      
ENSG00000187147 E007 0.0000000       1 44410584 44410687 104 +      
ENSG00000187147 E008 74.1978860 3.476161e-04 6.137747e-01 7.324111e-01 1 44411981 44412697 717 + 1.840 1.825 -0.051
ENSG00000187147 E009 20.0009868 1.018918e-03 6.266417e-01 7.425420e-01 1 44412698 44412722 25 + 1.297 1.264 -0.116
ENSG00000187147 E010 1.0727983 3.700215e-02 3.827525e-01 5.269170e-01 1 44412723 44412726 4 + 0.382 0.225 -1.054
ENSG00000187147 E011 3.2527210 2.380679e-01 6.486132e-01 7.600863e-01 1 44419304 44419872 569 + 0.460 0.617 0.733
ENSG00000187147 E012 0.0000000       1 44573002 44573005 4 +      
ENSG00000187147 E013 13.2673749 1.298078e-03 9.444818e-01 9.691911e-01 1 44614165 44614172 8 + 1.106 1.119 0.049
ENSG00000187147 E014 22.3017562 8.277426e-04 3.558678e-01 5.002298e-01 1 44614173 44614264 92 + 1.265 1.346 0.284
ENSG00000187147 E015 15.7321408 1.176163e-03 1.459082e-01 2.561093e-01 1 44614265 44614297 33 + 1.072 1.219 0.523
ENSG00000187147 E016 16.5894006 2.647185e-03 9.490214e-01 9.720440e-01 1 44622742 44622787 46 + 1.205 1.206 0.004
ENSG00000187147 E017 15.6245044 1.059350e-02 1.331052e-01 2.384551e-01 1 44626297 44626325 29 + 1.276 1.134 -0.501
ENSG00000187147 E018 24.4191636 1.315585e-02 1.281921e-01 2.316399e-01 1 44626326 44626398 73 + 1.451 1.323 -0.446
ENSG00000187147 E019 0.5202097 2.059083e-02 2.251579e-01 3.566086e-01 1 44626399 44627057 659 + 0.288 0.088 -2.059
ENSG00000187147 E020 1.5166337 9.206361e-03 4.428675e-01 5.844281e-01 1 44631600 44631731 132 + 0.459 0.328 -0.739
ENSG00000187147 E021 0.1451727 4.333672e-02 2.318546e-01   1 44631732 44631773 42 + 0.167 0.000 -10.348
ENSG00000187147 E022 3.2493134 6.152954e-03 6.638232e-01 7.717994e-01 1 44631774 44631960 187 + 0.633 0.569 -0.283
ENSG00000187147 E023 3.1625335 5.362339e-03 6.856437e-02 1.409905e-01 1 44631961 44631967 7 + 0.756 0.481 -1.212
ENSG00000187147 E024 9.6137547 2.277750e-02 6.376653e-08 6.727018e-07 1 44631968 44631974 7 + 1.336 0.666 -2.510
ENSG00000187147 E025 21.4290729 2.027557e-02 4.846244e-14 1.441122e-12 1 44631975 44631983 9 + 1.690 0.931 -2.669
ENSG00000187147 E026 291.1013314 5.319726e-03 9.043000e-07 7.579053e-06 1 44631984 44632208 225 + 2.546 2.355 -0.637
ENSG00000187147 E027 54.5913062 6.445899e-03 8.051252e-02 1.603543e-01 1 44632209 44632212 4 + 1.766 1.666 -0.340
ENSG00000187147 E028 2.0721289 1.441608e-01 9.332175e-01 9.619207e-01 1 44632235 44632254 20 + 0.459 0.473 0.070
ENSG00000187147 E029 35.6300748 5.680065e-04 2.495676e-02 6.178269e-02 1 44632255 44632342 88 + 1.607 1.478 -0.442
ENSG00000187147 E030 377.7321471 1.152254e-03 1.272479e-05 8.252903e-05 1 44632343 44632385 43 + 2.601 2.501 -0.332
ENSG00000187147 E031 3.7955594 4.370666e-03 6.724703e-01 7.784182e-01 1 44632645 44632895 251 + 0.678 0.619 -0.253
ENSG00000187147 E032 475.8039094 1.420514e-04 2.239071e-06 1.723210e-05 1 44635545 44635588 44 + 2.685 2.609 -0.251
ENSG00000187147 E033 208.0634373 2.214414e-04 9.109043e-01 9.473903e-01 1 44635589 44635666 78 + 2.269 2.273 0.015
ENSG00000187147 E034 840.6055565 1.086272e-04 6.680575e-01 7.751361e-01 1 44636030 44636162 133 + 2.870 2.883 0.045
ENSG00000187147 E035 61.2486535 1.202737e-02 3.203757e-02 7.592757e-02 1 44636163 44636495 333 + 1.622 1.794 0.581
ENSG00000187147 E036 4.2040010 3.802292e-03 5.955516e-05 3.292348e-04 1 44638296 44638415 120 + 0.997 0.447 -2.310
ENSG00000187147 E037 59.5591509 4.613413e-04 1.169371e-02 3.280565e-02 1 44643132 44644697 1566 + 1.813 1.698 -0.387
ENSG00000187147 E038 718.8672618 9.031795e-05 1.516317e-01 2.638744e-01 1 44644698 44644794 97 + 2.790 2.818 0.094
ENSG00000187147 E039 633.8441618 1.257792e-04 3.066270e-01 4.488106e-01 1 44644995 44645081 87 + 2.738 2.762 0.078
ENSG00000187147 E040 510.5040773 8.398442e-04 1.904566e-01 3.143311e-01 1 44645221 44645276 56 + 2.675 2.656 -0.066
ENSG00000187147 E041 564.5032014 1.589907e-04 8.354462e-02 1.650996e-01 1 44645410 44645488 79 + 2.720 2.699 -0.071
ENSG00000187147 E042 30.4545201 6.862132e-04 2.594509e-02 6.383485e-02 1 44648308 44649660 1353 + 1.327 1.494 0.579
ENSG00000187147 E043 657.6767764 2.084404e-04 1.924223e-01 3.168107e-01 1 44649661 44649769 109 + 2.782 2.769 -0.043
ENSG00000187147 E044 542.6156371 2.624008e-04 5.046513e-01 6.405616e-01 1 44649883 44649957 75 + 2.674 2.694 0.065
ENSG00000187147 E045 12.3152554 1.412361e-03 2.242559e-03 7.975036e-03 1 44649958 44649962 5 + 1.265 0.981 -1.023
ENSG00000187147 E046 101.8947945 2.607838e-03 1.662576e-01 2.833304e-01 1 44649963 44650703 741 + 2.001 1.947 -0.182
ENSG00000187147 E047 2398.3668266 6.139447e-04 2.624755e-16 1.074442e-14 1 44650704 44651753 1050 + 3.258 3.362 0.346