ENSG00000187109

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393263 ENSG00000187109 HEK293_OSMI2_2hA HEK293_TMG_2hB NAP1L1 protein_coding protein_coding 374.5503 273.6024 525.7278 19.61106 22.4732 0.9422101 94.87228 68.82206 135.60024 3.887980 7.823930 0.9783136 0.2519333 0.2523000 0.2576333 0.005333333 0.891576767 2.974217e-05 FALSE TRUE
ENST00000547773 ENSG00000187109 HEK293_OSMI2_2hA HEK293_TMG_2hB NAP1L1 protein_coding protein_coding 374.5503 273.6024 525.7278 19.61106 22.4732 0.9422101 45.02965 26.70819 64.57227 2.064005 3.614319 1.2733158 0.1154042 0.0976000 0.1227333 0.025133333 0.001085183 2.974217e-05 FALSE TRUE
ENST00000548044 ENSG00000187109 HEK293_OSMI2_2hA HEK293_TMG_2hB NAP1L1 protein_coding protein_coding 374.5503 273.6024 525.7278 19.61106 22.4732 0.9422101 89.08127 82.10480 102.44368 7.747255 7.370187 0.3192576 0.2535333 0.3011667 0.1943667 -0.106800000 0.003949714 2.974217e-05 FALSE TRUE
MSTRG.7677.2 ENSG00000187109 HEK293_OSMI2_2hA HEK293_TMG_2hB NAP1L1 protein_coding   374.5503 273.6024 525.7278 19.61106 22.4732 0.9422101 90.79768 56.96119 147.23604 7.665682 5.705167 1.3699245 0.2293208 0.2073333 0.2803000 0.072966667 0.056674820 2.974217e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187109 E001 355.3444545 0.0145462403 3.491532e-01 4.933694e-01 12 76036585 76046259 9675 - 2.580 2.505 -0.249
ENSG00000187109 E002 2178.4301483 0.0117624767 2.348928e-01 3.682290e-01 12 76046260 76046903 644 - 3.366 3.288 -0.260
ENSG00000187109 E003 1376.6427232 0.0050604188 5.694612e-09 7.359486e-08 12 76046904 76047154 251 - 3.221 2.989 -0.771
ENSG00000187109 E004 1211.8726648 0.0034667220 8.296769e-09 1.038244e-07 12 76047155 76047594 440 - 3.156 2.954 -0.671
ENSG00000187109 E005 186.1811035 0.0023224683 1.084349e-08 1.328333e-07 12 76047595 76047595 1 - 2.356 2.120 -0.789
ENSG00000187109 E006 450.1177134 0.0045471237 1.926127e-01 3.170387e-01 12 76047596 76047631 36 - 2.682 2.607 -0.249
ENSG00000187109 E007 355.9936852 0.0030029946 8.675347e-01 9.188238e-01 12 76047632 76047633 2 - 2.563 2.533 -0.101
ENSG00000187109 E008 1081.0910464 0.0050111017 1.695345e-02 4.483097e-02 12 76047634 76047718 85 - 3.000 3.069 0.229
ENSG00000187109 E009 631.2546196 0.0071336261 1.091574e-02 3.095971e-02 12 76047719 76047966 248 - 2.850 2.719 -0.436
ENSG00000187109 E010 323.2848550 0.0018285170 1.412705e-02 3.851275e-02 12 76047967 76048029 63 - 2.548 2.452 -0.318
ENSG00000187109 E011 772.8752090 0.0010342600 1.352876e-13 3.774087e-12 12 76048030 76048392 363 - 2.954 2.775 -0.594
ENSG00000187109 E012 940.7753734 0.0040649507 5.852027e-02 1.240968e-01 12 76048393 76048420 28 - 2.951 2.995 0.146
ENSG00000187109 E013 1622.4212808 0.0022715331 2.626426e-02 6.447862e-02 12 76048421 76048464 44 - 3.192 3.226 0.112
ENSG00000187109 E014 12.5427577 0.0018236890 3.682508e-03 1.224553e-02 12 76048995 76049145 151 - 1.242 0.924 -1.153
ENSG00000187109 E015 7.4760755 0.0594317503 4.154828e-02 9.390483e-02 12 76049146 76049199 54 - 1.043 0.675 -1.429
ENSG00000187109 E016 2003.2048617 0.0010225489 2.903279e-03 9.979272e-03 12 76049200 76049250 51 - 3.286 3.315 0.095
ENSG00000187109 E017 30.6397788 0.0006542485 1.311154e-02 3.616689e-02 12 76049251 76049428 178 - 1.568 1.381 -0.645
ENSG00000187109 E018 8.4692922 0.0228127999 1.757435e-01 2.956557e-01 12 76049429 76049433 5 - 0.900 1.053 0.568
ENSG00000187109 E019 21.1875179 0.0063950103 6.159138e-05 3.392836e-04 12 76049434 76049464 31 - 1.188 1.496 1.075
ENSG00000187109 E020 48.3280889 0.0020683142 7.162161e-11 1.294951e-09 12 76049465 76049525 61 - 1.521 1.852 1.125
ENSG00000187109 E021 8.0623186 0.0461512796 8.478316e-02 1.670593e-01 12 76049526 76049561 36 - 0.840 1.089 0.928
ENSG00000187109 E022 27.3738765 0.0068661050 8.611035e-09 1.074378e-07 12 76049562 76049588 27 - 1.223 1.647 1.465
ENSG00000187109 E023 487.2100266 0.0004124914 7.795017e-32 1.473795e-29 12 76049589 76049755 167 - 2.591 2.787 0.652
ENSG00000187109 E024 2261.9109255 0.0004113538 8.838897e-16 3.363806e-14 12 76049756 76049785 30 - 3.318 3.392 0.245
ENSG00000187109 E025 3321.9146010 0.0002193258 3.077315e-27 4.062635e-25 12 76050531 76050653 123 - 3.485 3.559 0.247
ENSG00000187109 E026 2014.5957809 0.0003804066 8.277073e-20 5.139517e-18 12 76053091 76053110 20 - 3.263 3.348 0.283
ENSG00000187109 E027 260.7733233 0.0001913222 1.936553e-01 3.183843e-01 12 76053111 76053158 48 - 2.437 2.382 -0.185
ENSG00000187109 E028 3011.2396924 0.0002825752 2.465358e-22 2.039540e-20 12 76053205 76053327 123 - 3.442 3.516 0.244
ENSG00000187109 E029 1509.0503812 0.0002663350 7.690633e-04 3.146730e-03 12 76053328 76053328 1 - 3.169 3.183 0.047
ENSG00000187109 E030 1826.9715199 0.0003229326 5.998876e-04 2.532691e-03 12 76053329 76053350 22 - 3.251 3.266 0.048
ENSG00000187109 E031 1805.9278377 0.0004456435 3.225076e-03 1.093028e-02 12 76053770 76053787 18 - 3.247 3.259 0.040
ENSG00000187109 E032 2043.0915121 0.0001538980 2.045519e-03 7.366690e-03 12 76053788 76053832 45 - 3.305 3.309 0.014
ENSG00000187109 E033 2678.0138373 0.0004986554 3.849924e-02 8.827631e-02 12 76053833 76053909 77 - 3.424 3.423 -0.004
ENSG00000187109 E034 1508.1373355 0.0006359829 4.546916e-01 5.953003e-01 12 76055019 76055019 1 - 3.181 3.165 -0.053
ENSG00000187109 E035 2155.6574504 0.0003869073 2.505151e-03 8.778848e-03 12 76055020 76055047 28 - 3.325 3.335 0.035
ENSG00000187109 E036 2029.1671835 0.0003642264 1.470741e-03 5.541737e-03 12 76055048 76055090 43 - 3.298 3.310 0.041
ENSG00000187109 E037 2688.9815136 0.0007886458 7.198188e-03 2.174019e-02 12 76056033 76056124 92 - 3.420 3.432 0.040
ENSG00000187109 E038 2059.1879644 0.0016784123 3.361834e-01 4.799974e-01 12 76056125 76056158 34 - 3.313 3.305 -0.028
ENSG00000187109 E039 1650.9500663 0.0016854119 6.280047e-01 7.436594e-01 12 76056159 76056161 3 - 3.230 3.190 -0.133
ENSG00000187109 E040 44.0630319 0.0004906763 3.065564e-07 2.830776e-06 12 76056162 76056573 412 - 1.762 1.443 -1.088
ENSG00000187109 E041 5.9383112 0.0297833258 4.867878e-02 1.068220e-01 12 76056574 76056672 99 - 0.954 0.631 -1.286
ENSG00000187109 E042 12.9715886 0.0027544923 9.171049e-09 1.138625e-07 12 76056673 76057743 1071 - 1.324 0.633 -2.608
ENSG00000187109 E043 4.5748879 0.0034458725 4.505619e-02 1.002992e-01 12 76057744 76057776 33 - 0.856 0.540 -1.323
ENSG00000187109 E044 5.1850797 0.0234541088 4.928249e-06 3.511913e-05 12 76057777 76057885 109 - 0.989 0.150 -4.412
ENSG00000187109 E045 2.8235573 0.0091265573 6.599016e-05 3.607560e-04 12 76059596 76059776 181 - 0.770 0.000 -12.234
ENSG00000187109 E046 10.2422888 0.0085079565 7.070621e-01 8.050784e-01 12 76059777 76059797 21 - 1.072 1.003 -0.253
ENSG00000187109 E047 1950.6586920 0.0017426552 7.896045e-02 1.578551e-01 12 76059798 76059820 23 - 3.314 3.246 -0.227
ENSG00000187109 E048 2431.2710897 0.0020538048 6.994276e-03 2.120920e-02 12 76059821 76059878 58 - 3.419 3.327 -0.306
ENSG00000187109 E049 3466.5030526 0.0015166351 3.659432e-04 1.642466e-03 12 76060138 76060279 142 - 3.575 3.477 -0.328
ENSG00000187109 E050 3.4342216 0.0298537742 1.680428e-02 4.450234e-02 12 76061010 76061087 78 - 0.789 0.348 -2.064
ENSG00000187109 E051 2604.0936830 0.0010277585 2.979804e-07 2.759789e-06 12 76067371 76067473 103 - 3.457 3.342 -0.383
ENSG00000187109 E052 7.7606408 0.0026998126 8.693321e-01 9.200171e-01 12 76067474 76067570 97 - 0.965 0.924 -0.154
ENSG00000187109 E053 7.3550166 0.0243304624 2.346878e-03 8.297885e-03 12 76068578 76068908 331 - 1.063 0.589 -1.875
ENSG00000187109 E054 2087.4074864 0.0018925442 2.951340e-07 2.735299e-06 12 76068909 76068994 86 - 3.372 3.227 -0.481
ENSG00000187109 E055 4.1854679 0.0038745281 2.764598e-02 6.730553e-02 12 76073805 76074202 398 - 0.840 0.485 -1.525
ENSG00000187109 E056 1396.8491739 0.0033544265 1.992359e-08 2.323605e-07 12 76074203 76074239 37 - 3.216 3.017 -0.663
ENSG00000187109 E057 21.6938655 0.0010664359 2.224604e-05 1.364605e-04 12 76083833 76084094 262 - 1.471 1.098 -1.309
ENSG00000187109 E058 1220.0671598 0.0044988807 6.061495e-06 4.234419e-05 12 76084567 76084676 110 - 3.153 2.966 -0.622
ENSG00000187109 E059 32.1437420 0.0036314064 6.399144e-01 7.532424e-01 12 76084677 76084735 59 - 1.540 1.486 -0.187
ENSG00000187109 E060 0.8126314 0.0142937192 4.154334e-01 5.588165e-01 12 76084928 76084983 56 - 0.307 0.150 -1.321