ENSG00000187091

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334661 ENSG00000187091 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCD1 protein_coding protein_coding 3.75139 4.899479 3.084758 0.3375532 0.2004582 -0.6657434 0.90067000 2.1516923 0.8665674 0.14141200 0.20436168 -1.3022243 0.21384583 0.44423333 0.27503333 -0.16920000 0.1523879240 0.0004947026 FALSE TRUE
ENST00000417185 ENSG00000187091 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCD1 protein_coding retained_intron 3.75139 4.899479 3.084758 0.3375532 0.2004582 -0.6657434 0.26826822 0.3734841 0.3009519 0.18701969 0.08313059 -0.3024753 0.06950417 0.07220000 0.09533333 0.02313333 0.7908587518 0.0004947026   FALSE
ENST00000461445 ENSG00000187091 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCD1 protein_coding retained_intron 3.75139 4.899479 3.084758 0.3375532 0.2004582 -0.6657434 0.22257848 0.1015700 0.3273323 0.02081293 0.05927699 1.5962215 0.06901667 0.02153333 0.10460000 0.08306667 0.0013371359 0.0004947026 TRUE TRUE
ENST00000463876 ENSG00000187091 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCD1 protein_coding protein_coding 3.75139 4.899479 3.084758 0.3375532 0.2004582 -0.6657434 1.35267802 1.2036197 1.5120566 0.08109389 0.13896921 0.3267056 0.38360833 0.24593333 0.49950000 0.25356667 0.0167178390 0.0004947026 FALSE TRUE
ENST00000484829 ENSG00000187091 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCD1 protein_coding retained_intron 3.75139 4.899479 3.084758 0.3375532 0.2004582 -0.6657434 0.29104025 0.4853277 0.0000000 0.24462886 0.00000000 -5.6303114 0.07796250 0.09326667 0.00000000 -0.09326667 0.2246008916 0.0004947026 FALSE FALSE
ENST00000495367 ENSG00000187091 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCD1 protein_coding retained_intron 3.75139 4.899479 3.084758 0.3375532 0.2004582 -0.6657434 0.30859114 0.1927438 0.0000000 0.19274378 0.00000000 -4.3415857 0.08010833 0.04480000 0.00000000 -0.04480000 0.8366867029 0.0004947026 FALSE FALSE
MSTRG.22708.5 ENSG00000187091 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCD1 protein_coding   3.75139 4.899479 3.084758 0.3375532 0.2004582 -0.6657434 0.08640999 0.3132598 0.0000000 0.09535275 0.00000000 -5.0146221 0.02484583 0.06340000 0.00000000 -0.06340000 0.0004947026 0.0004947026 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187091 E001 0.0000000       3 38007496 38007497 2 -      
ENSG00000187091 E002 1.5498429 0.5224693417 0.6411273244 0.754229736 3 38007498 38007532 35 - 0.268 0.452 1.101
ENSG00000187091 E003 47.1348402 0.0037016443 0.5583891318 0.686635635 3 38007533 38007858 326 - 1.630 1.666 0.121
ENSG00000187091 E004 40.6697114 0.0006124220 0.4988934415 0.635284640 3 38008014 38008163 150 - 1.564 1.602 0.128
ENSG00000187091 E005 1.8779542 0.0222490065 0.2457426259 0.380919367 3 38008164 38008234 71 - 0.554 0.350 -1.058
ENSG00000187091 E006 20.2181514 0.0009369713 0.3251896608 0.468627241 3 38008235 38008273 39 - 1.239 1.317 0.274
ENSG00000187091 E007 26.5852218 0.0008106076 0.2412400680 0.375642813 3 38008274 38008367 94 - 1.352 1.434 0.283
ENSG00000187091 E008 12.5645900 0.0014140075 0.2528881702 0.389323330 3 38008458 38008462 5 - 1.019 1.133 0.413
ENSG00000187091 E009 22.8639828 0.0009000053 0.0335635335 0.078897542 3 38008463 38008577 115 - 1.228 1.392 0.575
ENSG00000187091 E010 22.2027041 0.0016293391 0.0042206382 0.013759654 3 38008578 38008636 59 - 1.169 1.401 0.813
ENSG00000187091 E011 4.8305730 0.0034589353 0.0005038131 0.002174463 3 38008637 38009041 405 - 1.001 0.540 -1.872
ENSG00000187091 E012 33.8030644 0.0006228084 0.0877572189 0.171728111 3 38009042 38009158 117 - 1.435 1.541 0.367
ENSG00000187091 E013 44.4495823 0.0005048085 0.8336875030 0.895838915 3 38009272 38009431 160 - 1.634 1.623 -0.040
ENSG00000187091 E014 0.9577154 0.0156360918 0.5080063496 0.643446406 3 38009432 38009652 221 - 0.360 0.240 -0.802
ENSG00000187091 E015 42.9428242 0.0007750700 0.8752716253 0.923893221 3 38009653 38009811 159 - 1.617 1.607 -0.033
ENSG00000187091 E016 0.3697384 0.0274424043 0.3956084390 0.539414802 3 38009812 38009883 72 - 0.001 0.174 8.479
ENSG00000187091 E017 34.7470578 0.0123867064 0.3241500155 0.467520217 3 38009904 38010053 150 - 1.574 1.493 -0.278
ENSG00000187091 E018 4.4096468 0.0264792872 0.7575157238 0.842331609 3 38010054 38010130 77 - 0.724 0.676 -0.199
ENSG00000187091 E019 33.0844903 0.0008240679 0.4040043028 0.547736994 3 38010131 38010275 145 - 1.461 1.513 0.178
ENSG00000187091 E020 34.4523287 0.0006705560 0.4163880741 0.559747043 3 38010361 38010562 202 - 1.486 1.535 0.168
ENSG00000187091 E021 21.9285967 0.0011218528 0.5263115233 0.659559144 3 38011214 38011292 79 - 1.299 1.346 0.166
ENSG00000187091 E022 31.7545543 0.0007144416 0.1181292996 0.217259423 3 38011293 38011445 153 - 1.543 1.445 -0.335
ENSG00000187091 E023 31.5457059 0.0006719566 0.1858500459 0.308577858 3 38011544 38011673 130 - 1.532 1.449 -0.286
ENSG00000187091 E024 33.2033659 0.0007019465 0.0047200866 0.015151107 3 38016491 38016719 229 - 1.608 1.438 -0.582
ENSG00000187091 E025 0.0000000       3 38018970 38019034 65 -      
ENSG00000187091 E026 12.6787542 0.0014700807 0.0041659509 0.013608534 3 38020188 38020228 41 - 1.270 1.005 -0.949
ENSG00000187091 E027 22.0564970 0.0010112702 0.4940278117 0.631040137 3 38020229 38020352 124 - 1.368 1.317 -0.179
ENSG00000187091 E028 1.7306920 0.0088524428 0.3920698877 0.536009641 3 38024156 38024336 181 - 0.498 0.349 -0.799
ENSG00000187091 E029 15.7724076 0.0011978643 0.3222073712 0.465513323 3 38024337 38024787 451 - 1.249 1.163 -0.304
ENSG00000187091 E030 2.9139275 0.0060404652 0.0225043173 0.056729622 3 38029506 38029642 137 - 0.269 0.672 2.105