ENSG00000187079

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000526600 ENSG00000187079 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD1 protein_coding protein_coding 5.692837 3.519359 7.135754 0.1904421 0.13226 1.01768 1.2073460 1.97415304 0.04159942 0.29595698 0.04159942 -5.265025 0.29554167 0.56286667 0.005666667 -0.55720000 3.446056e-08 3.446056e-08 FALSE TRUE
ENST00000527575 ENSG00000187079 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD1 protein_coding protein_coding 5.692837 3.519359 7.135754 0.1904421 0.13226 1.01768 0.3842130 0.61788047 0.15570349 0.31401998 0.15570349 -1.921886 0.09090833 0.17973333 0.021666667 -0.15806667 3.979149e-01 3.446056e-08 FALSE TRUE
ENST00000527636 ENSG00000187079 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD1 protein_coding protein_coding 5.692837 3.519359 7.135754 0.1904421 0.13226 1.01768 1.1221763 0.05783351 2.45522635 0.05783351 0.33757883 5.183578 0.17302917 0.01843333 0.343466667 0.32503333 7.400690e-04 3.446056e-08 FALSE TRUE
MSTRG.5183.2 ENSG00000187079 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD1 protein_coding   5.692837 3.519359 7.135754 0.1904421 0.13226 1.01768 0.1174074 0.00000000 0.38879231 0.00000000 0.12532114 5.317566 0.02099583 0.00000000 0.053866667 0.05386667 2.288060e-03 3.446056e-08 FALSE TRUE
MSTRG.5183.6 ENSG00000187079 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD1 protein_coding   5.692837 3.519359 7.135754 0.1904421 0.13226 1.01768 1.7918292 0.54697688 2.58576153 0.13972306 0.39695587 2.220468 0.26282083 0.15210000 0.364500000 0.21240000 3.989065e-02 3.446056e-08 FALSE TRUE
MSTRG.5183.8 ENSG00000187079 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD1 protein_coding   5.692837 3.519359 7.135754 0.1904421 0.13226 1.01768 0.5025891 0.04686217 1.24449137 0.04686217 0.17442431 4.463490 0.06708750 0.01270000 0.174033333 0.16133333 3.968727e-05 3.446056e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000187079 E001 7.1065526 0.0218526347 7.845696e-06 5.339645e-05 11 12674421 12674616 196 + 0.892 0.386 -2.249
ENSG00000187079 E002 3.9698359 0.1211968438 3.802004e-04 1.698129e-03 11 12674617 12674633 17 + 0.697 0.000 -25.348
ENSG00000187079 E003 4.1170849 0.1365442345 4.346823e-04 1.907999e-03 11 12674634 12674683 50 + 0.710 0.000 -25.401
ENSG00000187079 E004 3.2440861 0.0588602474 3.017731e-04 1.386746e-03 11 12674684 12674766 83 + 0.629 0.000 -25.056
ENSG00000187079 E005 10.5754504 0.0017203911 1.346896e-02 3.700893e-02 11 12674767 12674834 68 + 0.961 1.013 0.194
ENSG00000187079 E006 9.3704029 0.0019188402 6.233994e-02 1.305904e-01 11 12675409 12675502 94 + 0.901 1.013 0.421
ENSG00000187079 E007 9.6263075 0.0049241641 8.644404e-03 2.539672e-02 11 12675503 12675561 59 + 0.939 0.948 0.033
ENSG00000187079 E008 33.7914911 0.0006468165 1.689946e-12 3.988480e-11 11 12764179 12764434 256 + 1.475 1.308 -0.578
ENSG00000187079 E009 0.0000000       11 12828121 12828335 215 +      
ENSG00000187079 E010 17.0519229 0.0011809945 3.240122e-06 2.406427e-05 11 12862250 12862314 65 + 1.186 1.070 -0.419
ENSG00000187079 E011 3.1012278 0.0050341463 7.439585e-02 1.505712e-01 11 12864686 12864748 63 + 0.546 0.498 -0.228
ENSG00000187079 E012 0.7374030 0.0156467238 5.345086e-01 6.665507e-01 11 12864749 12864837 89 + 0.202 0.234 0.273
ENSG00000187079 E013 10.2820122 0.0018454607 2.881669e-03 9.915967e-03 11 12864838 12864900 63 + 0.968 0.948 -0.073
ENSG00000187079 E014 0.3268771 0.0292595875 5.977107e-01   11 12864901 12865539 639 + 0.060 0.235 2.275
ENSG00000187079 E015 1.2126750 0.0129323996 1.925001e-01 3.169002e-01 11 12878889 12878900 12 + 0.309 0.234 -0.533
ENSG00000187079 E016 1.3212103 0.0119610790 4.028190e-03 1.322144e-02 11 12879443 12879707 265 + 0.060 0.725 4.862
ENSG00000187079 E017 20.6617376 0.0267628728 1.177016e-02 3.298309e-02 11 12879708 12879842 135 + 1.229 1.294 0.228
ENSG00000187079 E018 16.1164409 0.0223712528 3.474514e-05 2.032974e-04 11 12881005 12881051 47 + 1.173 0.983 -0.689
ENSG00000187079 E019 20.1066002 0.0474540982 2.733026e-04 1.271022e-03 11 12881896 12881957 62 + 1.259 1.099 -0.570
ENSG00000187079 E020 29.9143609 0.0071432881 1.321672e-08 1.592791e-07 11 12883001 12883125 125 + 1.422 1.277 -0.506
ENSG00000187079 E021 33.9793362 0.0005965624 1.102396e-10 1.931073e-09 11 12901940 12902113 174 + 1.471 1.365 -0.364
ENSG00000187079 E022 32.1097105 0.0587292812 2.102811e-03 7.542338e-03 11 12924912 12925052 141 + 1.439 1.385 -0.187
ENSG00000187079 E023 32.7509122 0.0007982190 1.183555e-05 7.732291e-05 11 12930174 12930326 153 + 1.425 1.482 0.197
ENSG00000187079 E024 1094.7922081 0.0385687717 2.929932e-08 3.303576e-07 11 12937109 12944737 7629 + 2.798 3.272 1.578