ENSG00000186998

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334018 ENSG00000186998 HEK293_OSMI2_2hA HEK293_TMG_2hB EMID1 protein_coding protein_coding 6.170316 12.31905 3.175262 0.4358231 0.09396551 -1.952578 2.7260586 4.894981 2.0241362 0.8146008 0.09334929 -1.269831 0.4780708 0.3936000 0.64036667 0.24676667 0.03968738 0.03968738 FALSE TRUE
ENST00000404820 ENSG00000186998 HEK293_OSMI2_2hA HEK293_TMG_2hB EMID1 protein_coding protein_coding 6.170316 12.31905 3.175262 0.4358231 0.09396551 -1.952578 0.8806278 1.846606 0.2148487 0.2190615 0.08115714 -3.045641 0.1261792 0.1514333 0.06626667 -0.08516667 0.16500036 0.03968738 FALSE TRUE
MSTRG.21900.5 ENSG00000186998 HEK293_OSMI2_2hA HEK293_TMG_2hB EMID1 protein_coding   6.170316 12.31905 3.175262 0.4358231 0.09396551 -1.952578 2.0616743 4.383335 0.7468808 0.3797328 0.12765358 -2.537179 0.3193458 0.3590000 0.23383333 -0.12516667 0.23859745 0.03968738 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186998 E001 1.0308674 0.0223516131 0.09056086 0.17601087 22 29205896 29205905 10 + 0.483 0.167 -2.120
ENSG00000186998 E002 1.0308674 0.0223516131 0.09056086 0.17601087 22 29205906 29205911 6 + 0.483 0.167 -2.120
ENSG00000186998 E003 1.3306760 0.0103711685 0.04863976 0.10675368 22 29205912 29205922 11 + 0.570 0.211 -2.123
ENSG00000186998 E004 1.7820001 0.0257558021 0.01068452 0.03041686 22 29205923 29205958 36 + 0.706 0.250 -2.388
ENSG00000186998 E005 28.0701094 0.0382125709 0.41863490 0.56187289 22 29205959 29206139 181 + 1.407 1.313 -0.324
ENSG00000186998 E006 53.1724501 0.0179569207 0.38258481 0.52679399 22 29214926 29215039 114 + 1.655 1.585 -0.237
ENSG00000186998 E007 46.3804430 0.0063878392 0.10667540 0.20064270 22 29215527 29215576 50 + 1.635 1.520 -0.391
ENSG00000186998 E008 50.8849374 0.0042877674 0.18535900 0.30794337 22 29215577 29215630 54 + 1.655 1.567 -0.299
ENSG00000186998 E009 26.4173295 0.0007840462 0.14915750 0.26052128 22 29225133 29225216 84 + 1.406 1.288 -0.410
ENSG00000186998 E010 0.4782907 0.0219242823 0.66691292 0.77428453 22 29226422 29226489 68 + 0.000 0.166 10.416
ENSG00000186998 E011 34.7349448 0.0006022412 0.43293831 0.57538120 22 29226490 29226551 62 + 1.470 1.411 -0.202
ENSG00000186998 E012 0.1817044 0.0391796487 1.00000000   22 29231018 29231019 2 + 0.000 0.063 8.805
ENSG00000186998 E013 50.0868551 0.0039850626 0.49508612 0.63194457 22 29231020 29231140 121 + 1.535 1.583 0.164
ENSG00000186998 E014 2.2443805 0.0066323783 0.26356728 0.40148615 22 29231458 29231508 51 + 0.225 0.458 1.461
ENSG00000186998 E015 32.4123417 0.0120669424 0.29055224 0.43137788 22 29231593 29231681 89 + 1.301 1.404 0.357
ENSG00000186998 E016 15.6953372 0.0014018612 0.48917153 0.62664962 22 29231682 29231682 1 + 1.022 1.099 0.280
ENSG00000186998 E017 0.7394768 0.0215521297 0.45580876 0.59630554 22 29231683 29232255 573 + 0.000 0.211 10.809
ENSG00000186998 E018 39.3605655 0.0067105156 0.66849844 0.77547423 22 29232256 29232335 80 + 1.439 1.474 0.119
ENSG00000186998 E019 46.6136272 0.0005669231 0.21557963 0.34511200 22 29232336 29232402 67 + 1.470 1.554 0.286
ENSG00000186998 E020 0.5180316 0.0224664226 0.66584251 0.77343519 22 29232403 29233345 943 + 0.000 0.167 10.414
ENSG00000186998 E021 0.7300267 0.0306549001 0.74998415 0.83678575 22 29233346 29233378 33 + 0.225 0.167 -0.534
ENSG00000186998 E022 67.3520381 0.0003849980 0.93365559 0.96220475 22 29233379 29233468 90 + 1.698 1.701 0.011
ENSG00000186998 E023 61.4899113 0.0004492211 0.20022875 0.32651658 22 29233614 29233666 53 + 1.599 1.674 0.253
ENSG00000186998 E024 0.3268771 0.0287029322 0.28620420   22 29233667 29233862 196 + 0.225 0.063 -2.122
ENSG00000186998 E025 66.2254413 0.0039335522 0.35243936 0.49669383 22 29234137 29234199 63 + 1.648 1.706 0.198
ENSG00000186998 E026 51.7650854 0.0005269923 0.99613765 1.00000000 22 29234305 29234349 45 + 1.591 1.590 -0.006
ENSG00000186998 E027 39.0706027 0.0092668718 0.64843980 0.75995357 22 29243445 29243489 45 + 1.439 1.478 0.134
ENSG00000186998 E028 46.6130327 0.0005783949 0.34914201 0.49336455 22 29254203 29254287 85 + 1.591 1.530 -0.209
ENSG00000186998 E029 1.7243598 0.0347900277 0.54208648 0.67292661 22 29254288 29254805 518 + 0.225 0.354 0.890
ENSG00000186998 E030 8.6862224 0.0019974083 0.37785756 0.52215635 22 29255271 29255361 91 + 0.760 0.887 0.496
ENSG00000186998 E031 0.8083901 0.0159608349 0.27347177 0.41251687 22 29255362 29255612 251 + 0.373 0.167 -1.539
ENSG00000186998 E032 217.8267192 0.0026909140 0.33287090 0.47654286 22 29258817 29259597 781 + 2.175 2.209 0.114