ENSG00000186908

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000426126 ENSG00000186908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC17 protein_coding protein_coding 9.521716 1.631845 15.01202 0.09921975 0.5329625 3.193689 5.9024802 0.60433731 9.33614604 0.07312036 0.36481159 3.927269 0.52661250 0.378633333 0.621800000 0.24316667 8.357525e-03 2.625501e-12 FALSE TRUE
ENST00000546778 ENSG00000186908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC17 protein_coding nonsense_mediated_decay 9.521716 1.631845 15.01202 0.09921975 0.5329625 3.193689 0.5536053 0.03348499 1.07061254 0.01691615 0.10179349 4.635188 0.03865000 0.020633333 0.071733333 0.05110000 8.445882e-02 2.625501e-12 TRUE TRUE
ENST00000549010 ENSG00000186908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC17 protein_coding processed_transcript 9.521716 1.631845 15.01202 0.09921975 0.5329625 3.193689 0.2459335 0.00000000 0.32118006 0.00000000 0.04125107 5.049544 0.05887917 0.000000000 0.021300000 0.02130000 1.292241e-01 2.625501e-12   FALSE
ENST00000550244 ENSG00000186908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC17 protein_coding retained_intron 9.521716 1.631845 15.01202 0.09921975 0.5329625 3.193689 0.4938986 0.87784482 0.06917017 0.19664929 0.03461829 -3.487279 0.18565000 0.527600000 0.004766667 -0.52283333 2.625501e-12 2.625501e-12 FALSE TRUE
ENST00000552453 ENSG00000186908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC17 protein_coding nonsense_mediated_decay 9.521716 1.631845 15.01202 0.09921975 0.5329625 3.193689 0.9669740 0.01540166 1.76767278 0.01540166 0.14090737 6.128923 0.05969167 0.009366667 0.118700000 0.10933333 7.758950e-04 2.625501e-12 TRUE TRUE
ENST00000552693 ENSG00000186908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC17 protein_coding retained_intron 9.521716 1.631845 15.01202 0.09921975 0.5329625 3.193689 0.8797416 0.10077580 1.65723219 0.05228368 0.24712771 3.911740 0.08679167 0.063700000 0.109566667 0.04586667 4.437987e-01 2.625501e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186908 E001 0.0000000       12 76764103 76764114 12 +      
ENSG00000186908 E002 3.0121561 0.0338637671 9.576375e-01 9.774447e-01 12 76764115 76764243 129 + 0.416 0.528 0.561
ENSG00000186908 E003 2.5788281 0.0059615266 7.788893e-01 8.577521e-01 12 76764244 76764252 9 + 0.369 0.528 0.821
ENSG00000186908 E004 2.7240008 0.0058508751 8.415358e-01 9.011725e-01 12 76764253 76764253 1 + 0.386 0.528 0.728
ENSG00000186908 E005 3.3088442 0.0122807503 9.265135e-01 9.577150e-01 12 76764254 76764257 4 + 0.445 0.528 0.407
ENSG00000186908 E006 24.2627565 0.0007555778 2.493549e-02 6.173973e-02 12 76764258 76764297 40 + 1.169 1.020 -0.539
ENSG00000186908 E007 26.7615131 0.0007286917 3.218496e-03 1.091013e-02 12 76764298 76764329 32 + 1.214 0.968 -0.891
ENSG00000186908 E008 0.4355181 0.6905986044 1.000000e+00 1.000000e+00 12 76764573 76764812 240 + 0.102 0.000 -20.180
ENSG00000186908 E009 0.0000000       12 76769073 76769201 129 +      
ENSG00000186908 E010 0.1472490 0.0428832879 6.125314e-01   12 76781625 76781628 4 + 0.037 0.000 -18.605
ENSG00000186908 E011 0.1472490 0.0428832879 6.125314e-01   12 76781629 76781683 55 + 0.037 0.000 -18.605
ENSG00000186908 E012 36.0072657 0.0007649948 1.249125e-04 6.362912e-04 12 76797434 76797518 85 + 1.339 1.020 -1.136
ENSG00000186908 E013 25.1458023 0.0007522335 1.387214e-04 6.979627e-04 12 76797519 76797537 19 + 1.197 0.759 -1.639
ENSG00000186908 E014 39.8196281 0.0015106194 1.671862e-03 6.192890e-03 12 76805317 76805439 123 + 1.375 1.182 -0.675
ENSG00000186908 E015 29.1959319 0.0007053093 1.371103e-01 2.440653e-01 12 76809043 76809120 78 + 1.235 1.215 -0.071
ENSG00000186908 E016 38.6189476 0.0010845079 2.548521e-03 8.907764e-03 12 76809713 76809857 145 + 1.362 1.182 -0.629
ENSG00000186908 E017 0.0000000       12 76813313 76813449 137 +      
ENSG00000186908 E018 32.5780448 0.0049171689 5.491931e-02 1.178610e-01 12 76815146 76815210 65 + 1.286 1.215 -0.251
ENSG00000186908 E019 23.8277955 0.0196935627 2.457993e-02 6.101077e-02 12 76815857 76815897 41 + 1.167 0.967 -0.727
ENSG00000186908 E020 41.5066031 0.0014112563 7.489893e-06 5.119377e-05 12 76815898 76816019 122 + 1.403 1.020 -1.360
ENSG00000186908 E021 5.3573209 0.0033970854 1.046342e-01 1.975665e-01 12 76821058 76821167 110 + 0.616 0.339 -1.401
ENSG00000186908 E022 42.6545422 0.0005220123 1.494516e-04 7.445932e-04 12 76822406 76822531 126 + 1.408 1.147 -0.916
ENSG00000186908 E023 35.8183567 0.0005933492 7.352830e-03 2.213455e-02 12 76826908 76827050 143 + 1.328 1.182 -0.513
ENSG00000186908 E024 31.3136686 0.0009800669 4.491363e-01 5.903363e-01 12 76828390 76828490 101 + 1.257 1.325 0.238
ENSG00000186908 E025 2.3713149 0.0398642110 1.568082e-01 2.708476e-01 12 76840059 76840390 332 + 0.386 0.000 -22.606
ENSG00000186908 E026 1.3318114 0.0096223766 3.985499e-01 5.422859e-01 12 76840391 76840483 93 + 0.256 0.000 -21.775
ENSG00000186908 E027 0.5997190 0.1308215110 1.000000e+00 1.000000e+00 12 76840965 76841106 142 + 0.133 0.000 -20.608
ENSG00000186908 E028 22.6362421 0.0008400712 6.680082e-01 7.751144e-01 12 76841982 76842024 43 + 1.122 1.215 0.330
ENSG00000186908 E029 34.0287518 0.0007479385 3.788882e-01 5.231876e-01 12 76842025 76842106 82 + 1.290 1.349 0.204
ENSG00000186908 E030 31.0725935 0.0018732259 6.652430e-01 7.729331e-01 12 76842919 76842981 63 + 1.249 1.349 0.351
ENSG00000186908 E031 19.2026174 0.0029097244 1.411423e-02 3.848555e-02 12 76843914 76844874 961 + 1.079 0.840 -0.893
ENSG00000186908 E032 6.7093039 0.0026432294 5.021300e-01 6.382222e-01 12 76844875 76844947 73 + 0.669 0.659 -0.044
ENSG00000186908 E033 20.6161216 0.0476585573 6.776891e-01 7.823320e-01 12 76844948 76845708 761 + 1.083 1.154 0.255
ENSG00000186908 E034 31.2895358 0.0013943530 2.102564e-01 3.388402e-01 12 76845709 76845802 94 + 1.261 1.273 0.042
ENSG00000186908 E035 0.8889184 0.0136245172 5.819466e-01 7.064081e-01 12 76846291 76846595 305 + 0.160 0.339 1.405
ENSG00000186908 E036 31.6424626 0.0006270631 5.601928e-01 6.882147e-01 12 76846596 76846679 84 + 1.261 1.349 0.305
ENSG00000186908 E037 20.9078382 0.0008630528 4.660657e-01 6.056339e-01 12 76848233 76848237 5 + 1.095 1.147 0.187
ENSG00000186908 E038 49.1324260 0.0004438934 1.308177e-01 2.352893e-01 12 76848238 76848390 153 + 1.449 1.469 0.070
ENSG00000186908 E039 36.9442342 0.0005558351 5.309035e-01 6.634306e-01 12 76849376 76849470 95 + 1.325 1.413 0.306
ENSG00000186908 E040 1.1887270 0.0111922903 2.139006e-01 3.431289e-01 12 76849471 76849669 199 + 0.187 0.527 2.141
ENSG00000186908 E041 390.7739548 0.0131271759 7.889143e-14 2.278315e-12 12 76850847 76853696 2850 + 2.280 2.711 1.437