ENSG00000186907

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335099 ENSG00000186907 HEK293_OSMI2_2hA HEK293_TMG_2hB RTN4RL2 protein_coding protein_coding 6.568075 9.773864 6.719724 0.8673737 0.2337093 -0.5398571 5.9500283 9.3711022 5.8383330 0.84273392 0.12825336 -0.6817320 0.89715833 0.95856667 0.86963333 -0.08893333 0.004399047 0.004399047 FALSE  
ENST00000395120 ENSG00000186907 HEK293_OSMI2_2hA HEK293_TMG_2hB RTN4RL2 protein_coding protein_coding 6.568075 9.773864 6.719724 0.8673737 0.2337093 -0.5398571 0.2735907 0.1920324 0.7466631 0.10024598 0.02330431 1.9050646 0.03967083 0.01986667 0.11160000 0.09173333 0.022502438 0.004399047 FALSE  
ENST00000533205 ENSG00000186907 HEK293_OSMI2_2hA HEK293_TMG_2hB RTN4RL2 protein_coding protein_coding 6.568075 9.773864 6.719724 0.8673737 0.2337093 -0.5398571 0.3444563 0.2107296 0.1347276 0.02437796 0.13472764 -0.6089398 0.06317083 0.02156667 0.01876667 -0.00280000 0.592146408 0.004399047 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186907 E001 26.160399 0.0007655532 0.286548481 0.426962736 11 57460528 57460856 329 + 1.447 1.380 -0.234
ENSG00000186907 E002 12.009081 0.0018186800 0.203118428 0.330134754 11 57460857 57460865 9 + 0.981 1.118 0.498
ENSG00000186907 E003 16.721444 0.0172508965 0.543334131 0.673967413 11 57460866 57460896 31 + 1.168 1.240 0.255
ENSG00000186907 E004 145.813085 0.0002689435 0.001212689 0.004684182 11 57467609 57468090 482 + 2.185 2.106 -0.267
ENSG00000186907 E005 3.294456 0.0048992235 0.033707826 0.079171893 11 57468562 57468769 208 + 0.789 0.474 -1.380
ENSG00000186907 E006 2.178707 0.0876888121 0.617622170 0.735396100 11 57468770 57468884 115 + 0.553 0.468 -0.408
ENSG00000186907 E007 342.236347 0.0010006288 0.002894632 0.009955334 11 57476162 57477534 1373 + 2.469 2.518 0.162