ENSG00000186866

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331343 ENSG00000186866 HEK293_OSMI2_2hA HEK293_TMG_2hB POFUT2 protein_coding protein_coding 23.69575 24.08983 22.08307 1.65149 0.6386953 -0.1254291 1.550953 1.256844 1.427029 0.0285102 0.02740593 0.1818503 0.0662375 0.05253333 0.06476667 0.01223333 0.50934882 0.03547817 FALSE TRUE
ENST00000349485 ENSG00000186866 HEK293_OSMI2_2hA HEK293_TMG_2hB POFUT2 protein_coding protein_coding 23.69575 24.08983 22.08307 1.65149 0.6386953 -0.1254291 15.110143 17.154392 12.899586 1.0378790 0.66290120 -0.4109760 0.6373917 0.71303333 0.58533333 -0.12770000 0.04256896 0.03547817 FALSE TRUE
ENST00000476653 ENSG00000186866 HEK293_OSMI2_2hA HEK293_TMG_2hB POFUT2 protein_coding processed_transcript 23.69575 24.08983 22.08307 1.65149 0.6386953 -0.1254291 1.450908 1.049284 2.697416 0.3820718 0.24377542 1.3538266 0.0618250 0.04170000 0.12176667 0.08006667 0.03547817 0.03547817 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186866 E001 2.140097 0.0070189855 7.932875e-01 8.678219e-01 21 45263928 45263928 1 - 0.461 0.511 0.246
ENSG00000186866 E002 2.802169 0.0054909373 2.870561e-01 4.275207e-01 21 45263929 45263934 6 - 0.461 0.639 0.830
ENSG00000186866 E003 36.848766 0.0091488939 6.622125e-03 2.024499e-02 21 45263935 45263978 44 - 1.420 1.638 0.744
ENSG00000186866 E004 730.963015 0.0009950119 1.920555e-10 3.228138e-09 21 45263979 45265373 1395 - 2.773 2.892 0.393
ENSG00000186866 E005 89.097221 0.0010584711 1.727930e-02 4.556417e-02 21 45265374 45265399 26 - 1.867 1.973 0.358
ENSG00000186866 E006 251.572254 0.0005133566 2.991805e-01 4.406758e-01 21 45265400 45265635 236 - 2.365 2.399 0.113
ENSG00000186866 E007 20.249737 0.0022176417 4.608898e-01 6.008739e-01 21 45265636 45266021 386 - 1.346 1.296 -0.173
ENSG00000186866 E008 25.036092 0.0007641172 4.951524e-01 6.320079e-01 21 45266022 45266227 206 - 1.367 1.423 0.194
ENSG00000186866 E009 60.461982 0.0003979440 1.310062e-02 3.614202e-02 21 45266228 45267525 1298 - 1.834 1.730 -0.352
ENSG00000186866 E010 9.292471 0.0080424482 2.519444e-01 3.882584e-01 21 45267526 45267589 64 - 1.078 0.959 -0.435
ENSG00000186866 E011 153.008243 0.0006724078 9.233241e-01 9.556591e-01 21 45267590 45267697 108 - 2.166 2.178 0.039
ENSG00000186866 E012 82.756385 0.0003228299 9.930418e-01 9.997810e-01 21 45267698 45267713 16 - 1.903 1.911 0.027
ENSG00000186866 E013 75.405776 0.0003576049 8.687127e-01 9.196177e-01 21 45269839 45269840 2 - 1.860 1.875 0.051
ENSG00000186866 E014 83.610832 0.0003077339 9.996098e-01 1.000000e+00 21 45269841 45269850 10 - 1.907 1.915 0.028
ENSG00000186866 E015 165.072898 0.0008624040 9.555508e-01 9.760943e-01 21 45269851 45270019 169 - 2.199 2.206 0.024
ENSG00000186866 E016 2.709513 0.0185819191 1.859214e-01 3.086467e-01 21 45270020 45270094 75 - 0.680 0.471 -0.949
ENSG00000186866 E017 165.312941 0.0003648622 2.020535e-01 3.287632e-01 21 45277017 45277142 126 - 2.220 2.193 -0.093
ENSG00000186866 E018 5.389616 0.0030178936 1.573184e-01 2.715309e-01 21 45277233 45277773 541 - 0.892 0.716 -0.694
ENSG00000186866 E019 146.774084 0.0003401361 1.089378e-01 2.039644e-01 21 45278103 45278169 67 - 2.180 2.141 -0.131
ENSG00000186866 E020 108.573561 0.0011961146 1.931023e-01 3.176680e-01 21 45282349 45282368 20 - 2.051 2.012 -0.132
ENSG00000186866 E021 108.803924 0.0003167775 2.372060e-01 3.709467e-01 21 45282369 45282398 30 - 2.045 2.013 -0.108
ENSG00000186866 E022 115.835070 0.0007280997 5.075686e-04 2.188491e-03 21 45282399 45282459 61 - 2.120 2.009 -0.370
ENSG00000186866 E023 7.651868 0.0037972774 5.230852e-01 6.568322e-01 21 45282804 45282938 135 - 0.969 0.903 -0.248
ENSG00000186866 E024 10.276409 0.0017071978 4.662239e-01 6.057892e-01 21 45283352 45283382 31 - 1.078 1.011 -0.245
ENSG00000186866 E025 184.794447 0.0002375728 6.406510e-03 1.967855e-02 21 45283383 45283527 145 - 2.291 2.228 -0.210
ENSG00000186866 E026 5.772689 0.0109092472 7.543075e-01 8.399906e-01 21 45285269 45285328 60 - 0.772 0.822 0.198
ENSG00000186866 E027 10.316332 0.0031564933 3.845946e-04 1.715126e-03 21 45285483 45285677 195 - 1.217 0.856 -1.327
ENSG00000186866 E028 226.475441 0.0024901865 4.700545e-03 1.509713e-02 21 45285678 45285928 251 - 2.390 2.309 -0.270
ENSG00000186866 E029 93.726419 0.0003498905 1.140017e-03 4.437402e-03 21 45287741 45287898 158 - 2.024 1.913 -0.374