ENSG00000186862

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370215 ENSG00000186862 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD7 protein_coding protein_coding 1.820264 3.329405 0.8502686 0.2157496 0.05700562 -1.956732 0.17204041 0.3188620 0.00000000 0.10353469 0.00000000 -5.03941052 0.08830417 0.09593333 0.0000000 -0.09593333 0.018951068 0.001184364 FALSE TRUE
ENST00000470414 ENSG00000186862 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD7 protein_coding retained_intron 1.820264 3.329405 0.8502686 0.2157496 0.05700562 -1.956732 0.88689017 2.3045054 0.19012485 0.16619964 0.15385369 -3.53173171 0.40903333 0.69156667 0.2074667 -0.48410000 0.084279752 0.001184364 FALSE TRUE
ENST00000474125 ENSG00000186862 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD7 protein_coding nonsense_mediated_decay 1.820264 3.329405 0.8502686 0.2157496 0.05700562 -1.956732 0.12565053 0.1005188 0.19178113 0.03232591 0.04974541 0.86849912 0.09444167 0.02946667 0.2274000 0.19793333 0.001184364 0.001184364 TRUE TRUE
ENST00000619208 ENSG00000186862 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD7 protein_coding protein_coding 1.820264 3.329405 0.8502686 0.2157496 0.05700562 -1.956732 0.32887851 0.3934389 0.20466547 0.05735318 0.01387288 -0.91025993 0.22460417 0.12153333 0.2449000 0.12336667 0.234148852 0.001184364 FALSE TRUE
ENST00000644782 ENSG00000186862 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD7 protein_coding protein_coding 1.820264 3.329405 0.8502686 0.2157496 0.05700562 -1.956732 0.07376281 0.1067213 0.09926816 0.07288522 0.01457566 -0.09519428 0.05376250 0.03083333 0.1184667 0.08763333 0.143186726 0.001184364 FALSE TRUE
ENST00000645349 ENSG00000186862 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD7 protein_coding protein_coding 1.820264 3.329405 0.8502686 0.2157496 0.05700562 -1.956732 0.14768968 0.0695246 0.16442896 0.04641115 0.05937105 1.13316650 0.08170417 0.02013333 0.2017333 0.18160000 0.023083013 0.001184364 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186862 E001 0.9514719 0.0589242039 7.381044e-01 8.280776e-01 10 101007679 101007809 131 - 0.188 0.252 0.536
ENSG00000186862 E002 16.3771355 0.0016745180 5.623510e-04 2.393415e-03 10 101007810 101008850 1041 - 1.377 1.083 -1.038
ENSG00000186862 E003 3.6387611 0.0097025065 6.569834e-02 1.362044e-01 10 101009250 101009350 101 - 0.808 0.524 -1.214
ENSG00000186862 E004 6.8179321 0.0042665146 5.773385e-03 1.801747e-02 10 101010272 101010879 608 - 1.074 0.738 -1.279
ENSG00000186862 E005 0.9158852 0.0148907030 2.298862e-01 3.623233e-01 10 101010880 101010883 4 - 0.420 0.200 -1.480
ENSG00000186862 E006 2.5904511 0.1006116768 6.540229e-02 1.357139e-01 10 101011039 101011689 651 - 0.728 0.379 -1.642
ENSG00000186862 E007 1.8703783 0.0310643174 2.850146e-01 4.253162e-01 10 101011690 101011761 72 - 0.570 0.372 -1.000
ENSG00000186862 E008 3.3169925 0.0915323500 7.536366e-01 8.395075e-01 10 101011925 101012016 92 - 0.629 0.584 -0.198
ENSG00000186862 E009 4.3813558 0.0038399836 4.334749e-01 5.758867e-01 10 101012167 101012258 92 - 0.570 0.690 0.523
ENSG00000186862 E010 3.9030650 0.0045579491 6.651644e-01 7.728607e-01 10 101015636 101015811 176 - 0.570 0.635 0.289
ENSG00000186862 E011 2.4063928 0.0906375632 9.043735e-01 9.430992e-01 10 101016377 101016427 51 - 0.502 0.491 -0.050
ENSG00000186862 E012 1.2156792 0.0118469641 9.177197e-01 9.520059e-01 10 101017332 101017376 45 - 0.319 0.296 -0.155
ENSG00000186862 E013 4.7511098 0.0060493078 5.314379e-01 6.638904e-01 10 101017377 101017615 239 - 0.770 0.673 -0.400
ENSG00000186862 E014 1.4811342 0.0100609261 1.349702e-02 3.707042e-02 10 101017616 101017783 168 - 0.629 0.200 -2.477
ENSG00000186862 E015 7.6169530 0.0026025253 7.411258e-01 8.304115e-01 10 101018099 101018296 198 - 0.906 0.860 -0.179
ENSG00000186862 E016 10.0525924 0.0022426799 3.884329e-01 5.325053e-01 10 101018822 101019217 396 - 1.054 0.954 -0.369
ENSG00000186862 E017 4.2425153 0.0039973513 5.613289e-01 6.891680e-01 10 101020618 101020678 61 - 0.728 0.635 -0.391
ENSG00000186862 E018 7.2556217 0.0023165117 2.387732e-01 3.727299e-01 10 101021798 101021945 148 - 0.961 0.810 -0.577
ENSG00000186862 E019 1.5553330 0.0090801482 2.847618e-05 1.702989e-04 10 101021946 101022208 263 - 0.770 0.077 -4.647
ENSG00000186862 E020 7.8250380 0.0024105632 1.905994e-02 4.946706e-02 10 101022209 101022385 177 - 1.074 0.797 -1.045
ENSG00000186862 E021 15.2876806 0.0015131745 1.492056e-06 1.193941e-05 10 101023128 101023435 308 - 0.629 1.225 2.277
ENSG00000186862 E022 21.6412845 0.0010119843 8.779966e-03 2.573273e-02 10 101023436 101023610 175 - 1.094 1.320 0.803
ENSG00000186862 E023 3.6721315 0.0354654734 3.255394e-01 4.689707e-01 10 101023611 101023927 317 - 0.728 0.551 -0.762
ENSG00000186862 E024 22.2331380 0.0009828608 7.136172e-03 2.157766e-02 10 101023928 101024068 141 - 1.112 1.340 0.804
ENSG00000186862 E025 14.9590599 0.0013410987 3.319816e-02 7.819292e-02 10 101029994 101030033 40 - 0.961 1.177 0.784
ENSG00000186862 E026 14.8097106 0.0013713662 2.026440e-01 3.295192e-01 10 101030034 101030061 28 - 1.032 1.154 0.439
ENSG00000186862 E027 17.4707947 0.0020787014 2.618499e-01 3.995705e-01 10 101030062 101030177 116 - 1.112 1.210 0.349
ENSG00000186862 E028 13.7485897 0.0015965676 1.932506e-01 3.178580e-01 10 101030178 101030384 207 - 0.986 1.117 0.478
ENSG00000186862 E029 0.1817044 0.0397878260 1.000000e+00   10 101030512 101030684 173 - 0.000 0.077 8.730
ENSG00000186862 E030 0.0000000       10 101030685 101030768 84 -      
ENSG00000186862 E031 4.6936600 0.1449345465 7.562686e-01 8.413669e-01 10 101031073 101031144 72 - 0.727 0.669 -0.241
ENSG00000186862 E032 0.1451727 0.0441760744 1.716084e-01   10 101032069 101032295 227 - 0.188 0.000 -11.814