ENSG00000186812

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330501 ENSG00000186812 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF397 protein_coding protein_coding 11.34958 4.947354 14.87043 0.3331909 0.1161943 1.585774 5.0468608 2.3324292 5.629925 0.314518729 0.28746068 1.267670 0.45837083 0.46763333 0.37843333 -0.08920000 2.462027e-01 7.382353e-09 FALSE  
ENST00000589630 ENSG00000186812 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF397 protein_coding retained_intron 11.34958 4.947354 14.87043 0.3331909 0.1161943 1.585774 0.6579575 0.0000000 1.078538 0.000000000 0.08694372 6.766247 0.04596250 0.00000000 0.07246667 0.07246667 7.382353e-09 7.382353e-09 FALSE  
ENST00000591206 ENSG00000186812 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF397 protein_coding protein_coding 11.34958 4.947354 14.87043 0.3331909 0.1161943 1.585774 1.5084016 0.9892677 2.232235 0.003052089 0.16757164 1.165995 0.13856250 0.20170000 0.15006667 -0.05163333 2.942774e-01 7.382353e-09 FALSE  
ENST00000591505 ENSG00000186812 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF397 protein_coding retained_intron 11.34958 4.947354 14.87043 0.3331909 0.1161943 1.585774 0.8427085 0.4601067 1.005200 0.066115893 0.06992198 1.110704 0.08166667 0.09516667 0.06753333 -0.02763333 4.771480e-01 7.382353e-09    
MSTRG.15684.9 ENSG00000186812 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF397 protein_coding   11.34958 4.947354 14.87043 0.3331909 0.1161943 1.585774 1.5259129 0.4662489 2.382508 0.078267922 0.30153386 2.328736 0.12273333 0.09350000 0.16043333 0.06693333 1.693661e-01 7.382353e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186812 E001 0.1482932 0.0413036756 0.174911731   18 35241030 35241033 4 + 0.000 0.195 10.775
ENSG00000186812 E002 0.1482932 0.0413036756 0.174911731   18 35241034 35241035 2 + 0.000 0.195 12.889
ENSG00000186812 E003 0.1482932 0.0413036756 0.174911731   18 35241036 35241036 1 + 0.000 0.195 12.889
ENSG00000186812 E004 0.2955422 0.0298868994 0.467424280   18 35241037 35241042 6 + 0.074 0.195 1.604
ENSG00000186812 E005 1.0425102 0.0126202675 0.426325134 0.569175600 18 35241043 35241050 8 + 0.326 0.195 -0.980
ENSG00000186812 E006 2.0973271 0.0072675550 0.259741424 0.397197694 18 35241051 35241054 4 + 0.510 0.329 -0.979
ENSG00000186812 E007 2.2488425 0.0064713001 0.206321845 0.334100235 18 35241055 35241056 2 + 0.535 0.329 -1.094
ENSG00000186812 E008 7.9213915 0.0025312849 0.869580162 0.920148396 18 35241057 35241071 15 + 0.887 0.952 0.245
ENSG00000186812 E009 21.1209137 0.0008749892 0.174492414 0.294039212 18 35241072 35241109 38 + 1.321 1.256 -0.228
ENSG00000186812 E010 16.7055090 0.0103744952 0.175710190 0.295610117 18 35241110 35241506 397 + 1.227 1.131 -0.341
ENSG00000186812 E011 9.2547182 0.0019135220 0.011399062 0.032115135 18 35241507 35241601 95 + 1.029 0.744 -1.093
ENSG00000186812 E012 9.7977299 0.0021159522 0.016881241 0.044671199 18 35241602 35241690 89 + 1.044 0.786 -0.977
ENSG00000186812 E013 1.6588022 0.2500783644 0.287497035 0.427995715 18 35242390 35242390 1 + 0.457 0.196 -1.710
ENSG00000186812 E014 31.4694231 0.0007530015 0.035852406 0.083297592 18 35242391 35242472 82 + 1.494 1.395 -0.341
ENSG00000186812 E015 65.9888386 0.0009693850 0.002347296 0.008299153 18 35242473 35242794 322 + 1.806 1.703 -0.350
ENSG00000186812 E016 35.7048697 0.0077610215 0.026537731 0.065028630 18 35242795 35242884 90 + 1.552 1.425 -0.435
ENSG00000186812 E017 6.4624852 0.0025554329 0.018119902 0.047386991 18 35242885 35242941 57 + 0.898 0.584 -1.280
ENSG00000186812 E018 1.6178904 0.0086682817 0.016929647 0.044778026 18 35242942 35242952 11 + 0.484 0.000 -14.967
ENSG00000186812 E019 2.8119160 0.0052500655 0.014405208 0.039144305 18 35242953 35243000 48 + 0.639 0.195 -2.564
ENSG00000186812 E020 58.4948402 0.0264009070 0.145454783 0.255471962 18 35243152 35243293 142 + 1.755 1.669 -0.291
ENSG00000186812 E021 45.0269352 0.0013834977 0.001183757 0.004586218 18 35243294 35244100 807 + 1.541 1.770 0.779
ENSG00000186812 E022 44.0272979 0.0019003201 0.057228185 0.121856650 18 35245262 35245351 90 + 1.627 1.559 -0.232
ENSG00000186812 E023 97.6717127 0.0013495143 0.014860377 0.040173721 18 35245352 35245798 447 + 1.959 1.907 -0.176
ENSG00000186812 E024 566.7024745 0.0074723144 0.002787464 0.009636965 18 35245799 35249808 4010 + 2.668 2.796 0.425
ENSG00000186812 E025 3.3854177 0.1598875005 0.395755744 0.539546361 18 35254197 35254231 35 + 0.536 0.773 1.019
ENSG00000186812 E026 16.3829187 0.1110136011 0.685925590 0.788533343 18 35254232 35254402 171 + 1.154 1.310 0.549
ENSG00000186812 E027 17.0291420 0.0152726361 0.052111098 0.112919102 18 35257928 35258049 122 + 1.136 1.382 0.863
ENSG00000186812 E028 32.1167663 0.0271778461 0.791137943 0.866426048 18 35258050 35259227 1178 + 1.457 1.533 0.261
ENSG00000186812 E029 2.4638432 0.0087389480 0.708989259 0.806498589 18 35266693 35267133 441 + 0.484 0.584 0.468