ENSG00000186806

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335624 ENSG00000186806 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIG10L protein_coding protein_coding 1.45941 2.265022 0.9317381 0.1468555 0.04092695 -1.272483 0.05641211 0.0482301 0.1410328 0.001950583 0.06105632 1.375025 0.04932917 0.02156667 0.1461333 0.1245667 0.03503307 0.03192245 FALSE TRUE
ENST00000600663 ENSG00000186806 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIG10L protein_coding processed_transcript 1.45941 2.265022 0.9317381 0.1468555 0.04092695 -1.272483 1.39430294 2.2167921 0.7907053 0.148333682 0.02287904 -1.475624 0.94552500 0.97843333 0.8538667 -0.1245667 0.03192245 0.03192245 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186806 E001 0.8126288 0.181939993 0.265721652 0.40380355 19 51330667 51330699 33 - 0.000 0.268 10.114
ENSG00000186806 E002 0.2955422 0.029136963 0.496098376   19 51331536 51331540 5 - 0.178 0.082 -1.285
ENSG00000186806 E003 49.5192384 0.015139977 0.018930435 0.04917879 19 51331541 51332406 866 - 1.511 1.684 0.589
ENSG00000186806 E004 24.4969711 0.001011270 0.571798416 0.69803202 19 51332407 51332640 234 - 1.358 1.336 -0.079
ENSG00000186806 E005 18.4969382 0.001111029 0.252769454 0.38918597 19 51333791 51333945 155 - 1.285 1.210 -0.263
ENSG00000186806 E006 16.0927924 0.008356112 0.964603859 0.98168319 19 51334191 51334304 114 - 1.152 1.166 0.050
ENSG00000186806 E007 20.6871305 0.001071562 0.512474875 0.64739226 19 51337238 51337534 297 - 1.296 1.263 -0.116
ENSG00000186806 E008 14.6805730 0.001516763 0.950876954 0.97326186 19 51337930 51338208 279 - 1.120 1.131 0.041
ENSG00000186806 E009 6.9569564 0.002491186 0.911983525 0.94817438 19 51338888 51339142 255 - 0.818 0.848 0.117
ENSG00000186806 E010 0.5180316 0.024436324 0.350422628 0.49459497 19 51339664 51339755 92 - 0.000 0.211 11.645
ENSG00000186806 E011 1.3973861 0.011616008 0.018342579 0.04788143 19 51340015 51340299 285 - 0.607 0.211 -2.283
ENSG00000186806 E012 0.4427912 0.115915473 0.197877631 0.32356825 19 51340433 51340726 294 - 0.304 0.082 -2.292
ENSG00000186806 E013 1.9060432 0.125111304 0.007477911 0.02245578 19 51341153 51342007 855 - 0.745 0.213 -2.849
ENSG00000186806 E014 0.0000000       19 51342085 51342139 55 -