ENSG00000186716

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305877 ENSG00000186716 HEK293_OSMI2_2hA HEK293_TMG_2hB BCR protein_coding protein_coding 48.82401 78.77495 33.10676 4.999049 0.8404187 -1.250359 18.469393 26.5479506 16.399895 3.2848844 1.0832945 -0.6945778 0.3813042 0.334233333 0.49490000 0.16066667 0.003299118 0.002068445 FALSE TRUE
ENST00000427791 ENSG00000186716 HEK293_OSMI2_2hA HEK293_TMG_2hB BCR protein_coding protein_coding 48.82401 78.77495 33.10676 4.999049 0.8404187 -1.250359 1.933060 0.7261798 2.167161 0.3700711 0.1140393 1.5643179 0.0532500 0.008666667 0.06570000 0.05703333 0.124326906 0.002068445 FALSE FALSE
ENST00000475025 ENSG00000186716 HEK293_OSMI2_2hA HEK293_TMG_2hB BCR protein_coding processed_transcript 48.82401 78.77495 33.10676 4.999049 0.8404187 -1.250359 16.097099 27.9125047 9.602782 1.4654243 0.7147750 -1.5384025 0.3175583 0.354866667 0.28970000 -0.06516667 0.094827062 0.002068445 FALSE FALSE
MSTRG.21779.5 ENSG00000186716 HEK293_OSMI2_2hA HEK293_TMG_2hB BCR protein_coding   48.82401 78.77495 33.10676 4.999049 0.8404187 -1.250359 9.218309 19.1754409 3.152697 0.4759219 0.5916992 -2.6007846 0.1831208 0.245933333 0.09586667 -0.15006667 0.002068445 0.002068445 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186716 E001 0.3686942 0.0294999011 4.865420e-01 6.242561e-01 22 23179704 23179832 129 + 0.184 0.079 -1.395
ENSG00000186716 E002 0.2214452 0.0386974278 1.000000e+00   22 23180365 23180508 144 + 0.000 0.080 8.966
ENSG00000186716 E003 6.4300516 0.0880217198 1.524830e-04 7.580414e-04 22 23180509 23180614 106 + 1.199 0.537 -2.600
ENSG00000186716 E004 197.7398117 0.0141171918 3.790161e-09 5.047696e-08 22 23180615 23181426 812 + 2.474 2.108 -1.222
ENSG00000186716 E005 809.7112674 0.0050022901 2.965868e-05 1.767180e-04 22 23181427 23182239 813 + 2.943 2.800 -0.475
ENSG00000186716 E006 0.0000000       22 23198253 23198331 79 +      
ENSG00000186716 E007 0.2214452 0.0386974278 1.000000e+00   22 23198332 23198385 54 + 0.000 0.080 8.966
ENSG00000186716 E008 0.0000000       22 23199211 23199352 142 +      
ENSG00000186716 E009 0.1451727 0.0431227215 1.836684e-01   22 23242818 23242985 168 + 0.184 0.000 -12.032
ENSG00000186716 E010 0.0000000       22 23251032 23251240 209 +      
ENSG00000186716 E011 354.8204396 0.0029247014 1.652113e-04 8.145634e-04 22 23253799 23253959 161 + 2.570 2.446 -0.412
ENSG00000186716 E012 159.2151796 0.0040908787 4.635854e-03 1.491971e-02 22 23253960 23253980 21 + 2.225 2.101 -0.417
ENSG00000186716 E013 303.8375669 0.0027046786 2.432583e-03 8.559856e-03 22 23260950 23261054 105 + 2.488 2.387 -0.339
ENSG00000186716 E014 435.9617502 0.0014347073 4.831642e-04 2.095799e-03 22 23261355 23261540 186 + 2.637 2.545 -0.306
ENSG00000186716 E015 351.9620452 0.0034016209 2.734735e-02 6.670110e-02 22 23268408 23268515 108 + 2.533 2.457 -0.253
ENSG00000186716 E016 326.0474930 0.0042295894 1.963865e-02 5.071303e-02 22 23271532 23271592 61 + 2.508 2.421 -0.290
ENSG00000186716 E017 312.4750339 0.0034515603 1.645922e-02 4.374692e-02 22 23273081 23273133 53 + 2.487 2.402 -0.282
ENSG00000186716 E018 450.5032443 0.0024569471 2.074951e-01 3.354889e-01 22 23273634 23273774 141 + 2.612 2.574 -0.127
ENSG00000186716 E019 3.5406012 0.0044361379 9.337507e-01 9.622556e-01 22 23283209 23283787 579 + 0.620 0.603 -0.077
ENSG00000186716 E020 1.9436295 0.0074567429 9.706809e-01 9.856895e-01 22 23283788 23283976 189 + 0.412 0.416 0.018
ENSG00000186716 E021 355.9823047 0.0005243298 6.222889e-01 7.391178e-01 22 23283977 23284098 122 + 2.474 2.482 0.026
ENSG00000186716 E022 442.4510137 0.0001424460 2.183107e-01 3.483743e-01 22 23285033 23285201 169 + 2.594 2.566 -0.096
ENSG00000186716 E023 442.9067070 0.0001271272 1.472286e-01 2.579132e-01 22 23287159 23287278 120 + 2.600 2.567 -0.110
ENSG00000186716 E024 336.3441099 0.0009315257 5.845333e-01 7.084335e-01 22 23288097 23288172 76 + 2.449 2.460 0.036
ENSG00000186716 E025 388.7156293 0.0001882381 4.571467e-01 5.975071e-01 22 23289517 23289614 98 + 2.510 2.521 0.037
ENSG00000186716 E026 215.7551584 0.0002174729 9.281083e-01 9.587326e-01 22 23289615 23289621 7 + 2.264 2.262 -0.008
ENSG00000186716 E027 0.3686942 0.0294999011 4.865420e-01 6.242561e-01 22 23289622 23290338 717 + 0.184 0.079 -1.395
ENSG00000186716 E028 380.2326476 0.0001505464 2.057793e-01 3.333956e-01 22 23290339 23290413 75 + 2.492 2.514 0.074
ENSG00000186716 E029 0.0000000       22 23290414 23291131 718 +      
ENSG00000186716 E030 458.2597802 0.0001713332 5.323782e-01 6.647516e-01 22 23292541 23292638 98 + 2.584 2.591 0.025
ENSG00000186716 E031 292.4528316 0.0013173038 7.315144e-01 8.231558e-01 22 23295024 23295040 17 + 2.392 2.399 0.022
ENSG00000186716 E032 523.1852555 0.0007331199 7.694359e-02 1.546045e-01 22 23295041 23295155 115 + 2.621 2.656 0.117
ENSG00000186716 E033 8.5551430 0.0303463039 7.051220e-02 1.441916e-01 22 23302341 23302863 523 + 0.672 0.960 1.135
ENSG00000186716 E034 3.7974442 0.0053734914 3.196091e-02 7.578380e-02 22 23304489 23304624 136 + 0.313 0.699 1.922
ENSG00000186716 E035 0.9263925 0.2043765993 6.429562e-01 7.556074e-01 22 23306154 23306249 96 + 0.184 0.294 0.872
ENSG00000186716 E036 1.6145875 0.0090341654 3.066915e-02 7.327202e-02 22 23306745 23306830 86 + 0.000 0.448 12.132
ENSG00000186716 E037 1.5812780 0.0090537383 7.077265e-01 8.055314e-01 22 23307568 23307764 197 + 0.313 0.381 0.410
ENSG00000186716 E038 343.2048954 0.0001616181 9.264200e-02 1.792557e-01 22 23309424 23309473 50 + 2.437 2.470 0.110
ENSG00000186716 E039 250.7402419 0.0001731880 6.644245e-01 7.722379e-01 22 23309474 23309483 10 + 2.323 2.329 0.021
ENSG00000186716 E040 3.6888970 0.0057493897 1.132864e-01 2.103168e-01 22 23309484 23309942 459 + 0.798 0.557 -1.021
ENSG00000186716 E041 6.8494337 0.0058463853 3.525173e-01 4.967706e-01 22 23309943 23310323 381 + 0.718 0.847 0.513
ENSG00000186716 E042 478.0290699 0.0002039544 1.581097e-01 2.725946e-01 22 23310324 23310433 110 + 2.590 2.613 0.076
ENSG00000186716 E043 574.9898807 0.0001224456 6.865461e-06 4.737356e-05 22 23311697 23311836 140 + 2.629 2.704 0.249
ENSG00000186716 E044 5.3075964 0.4360798259 4.960761e-01 6.328075e-01 22 23311837 23311918 82 + 0.717 0.749 0.131
ENSG00000186716 E045 5.8455407 0.0030679753 6.004825e-02 1.266825e-01 22 23312388 23312886 499 + 0.951 0.700 -0.983
ENSG00000186716 E046 577.5594949 0.0009666438 2.953101e-03 1.012506e-02 22 23312887 23313021 135 + 2.641 2.705 0.213
ENSG00000186716 E047 500.5742625 0.0020955962 5.273031e-04 2.261881e-03 22 23313968 23314073 106 + 2.554 2.652 0.325
ENSG00000186716 E048 612.5930371 0.0026343071 5.364216e-06 3.791355e-05 22 23314552 23314714 163 + 2.613 2.746 0.444
ENSG00000186716 E049 1788.7316171 0.0033948229 1.569064e-05 9.969292e-05 22 23315433 23318037 2605 + 3.093 3.208 0.385