ENSG00000186638

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379174 ENSG00000186638 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF24 protein_coding protein_coding 3.706311 3.150408 3.847581 0.1648999 0.09671345 0.2875856 1.0367224 1.435463689 0.8013944 0.042562186 0.2363003 -0.8330570 0.29711667 0.459333333 0.2084667 -0.25086667 0.03471751 0.03471751 FALSE TRUE
ENST00000402558 ENSG00000186638 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF24 protein_coding protein_coding 3.706311 3.150408 3.847581 0.1648999 0.09671345 0.2875856 2.3983176 1.644063234 2.7223620 0.252973366 0.3161591 0.7241342 0.63469167 0.516900000 0.7083000 0.19140000 0.29246395 0.03471751 FALSE TRUE
MSTRG.32577.3 ENSG00000186638 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF24 protein_coding   3.706311 3.150408 3.847581 0.1648999 0.09671345 0.2875856 0.1658219 0.008781939 0.2137025 0.008781939 0.1193135 3.5741634 0.04069167 0.002933333 0.0541000 0.05116667 0.34935273 0.03471751 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186638 E001 2.577804 0.0150791654 3.143853e-01 4.571010e-01 9 34252380 34252380 1 - 0.434 0.638 0.961
ENSG00000186638 E002 188.812977 0.0120035463 2.385811e-08 2.739634e-07 9 34252381 34253904 1524 - 2.099 2.414 1.052
ENSG00000186638 E003 80.000435 0.0004021017 2.028903e-02 5.208755e-02 9 34253905 34254520 616 - 1.834 1.975 0.474
ENSG00000186638 E004 26.978942 0.0014855060 8.920374e-01 9.350520e-01 9 34255072 34255165 94 - 1.422 1.465 0.146
ENSG00000186638 E005 217.702555 0.0051167883 1.728846e-01 2.919401e-01 9 34255735 34257981 2247 - 2.334 2.345 0.037
ENSG00000186638 E006 28.258288 0.0007867608 3.715049e-03 1.234031e-02 9 34259596 34259705 110 - 1.523 1.386 -0.469
ENSG00000186638 E007 16.777967 0.0014732938 5.287895e-02 1.142758e-01 9 34263101 34263172 72 - 1.298 1.189 -0.385
ENSG00000186638 E008 15.563912 0.0433468794 1.582272e-01 2.727516e-01 9 34269257 34269362 106 - 1.284 1.143 -0.499
ENSG00000186638 E009 15.538930 0.0195553213 2.225842e-01 3.534789e-01 9 34271809 34271930 122 - 1.258 1.178 -0.286
ENSG00000186638 E010 12.029092 0.0068006647 2.344196e-01 3.676575e-01 9 34286617 34286704 88 - 1.142 1.071 -0.257
ENSG00000186638 E011 18.478297 0.0011146123 3.185254e-02 7.556751e-02 9 34290174 34290389 216 - 1.346 1.228 -0.410
ENSG00000186638 E012 10.820410 0.0094453281 4.622473e-01 6.021044e-01 9 34297017 34297114 98 - 1.095 1.068 -0.096
ENSG00000186638 E013 20.768723 0.0141434556 1.311016e-02 3.616414e-02 9 34306252 34306441 190 - 1.418 1.244 -0.606
ENSG00000186638 E014 31.687360 0.0026541585 2.325405e-07 2.202044e-06 9 34310724 34311121 398 - 1.628 1.338 -0.998
ENSG00000186638 E015 21.790539 0.0022359316 8.761988e-05 4.638756e-04 9 34311122 34311371 250 - 1.458 1.209 -0.868
ENSG00000186638 E016 1.332955 0.3432669070 3.837071e-01 5.279062e-01 9 34319440 34319623 184 - 0.434 0.249 -1.152
ENSG00000186638 E017 14.317819 0.0013281151 2.035592e-04 9.791213e-04 9 34329106 34329296 191 - 1.298 1.011 -1.027