ENSG00000186594

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000574306 ENSG00000186594 HEK293_OSMI2_2hA HEK293_TMG_2hB MIR22HG lncRNA lncRNA 0.9949862 1.158134 1.413095 0.2578784 0.1428169 0.2848261 0.83266917 0.7951128 1.1761500 0.1946587 0.078539324 0.5590236 0.80369167 0.7547 0.84050000 0.08580000 0.95373509 0.02787045    
ENST00000577164 ENSG00000186594 HEK293_OSMI2_2hA HEK293_TMG_2hB MIR22HG lncRNA lncRNA 0.9949862 1.158134 1.413095 0.2578784 0.1428169 0.2848261 0.03754243 0.0000000 0.0984204 0.0000000 0.006782433 3.4385644 0.06613333 0.0000 0.07196667 0.07196667 0.02787045 0.02787045    
ENST00000686705 ENSG00000186594 HEK293_OSMI2_2hA HEK293_TMG_2hB MIR22HG lncRNA lncRNA 0.9949862 1.158134 1.413095 0.2578784 0.1428169 0.2848261 0.03650621 0.2354975 0.0000000 0.2354975 0.000000000 -4.6176362 0.02375833 0.1479 0.00000000 -0.14790000 0.72961684 0.02787045    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186594 E001 0.0000000       17 1711447 1711501 55 -      
ENSG00000186594 E002 0.0000000       17 1711502 1711502 1 -      
ENSG00000186594 E003 0.0000000       17 1711503 1711503 1 -      
ENSG00000186594 E004 0.0000000       17 1711504 1711506 3 -      
ENSG00000186594 E005 0.0000000       17 1711507 1711518 12 -      
ENSG00000186594 E006 7.0762132 0.002577132 0.87140749 0.92129743 17 1711519 1711716 198 - 0.900 0.922 0.083
ENSG00000186594 E007 3.7191997 0.004938728 0.17037653 0.28865945 17 1711717 1711717 1 - 0.570 0.771 0.851
ENSG00000186594 E008 6.1194387 0.002889521 0.11368939 0.21090465 17 1711718 1711770 53 - 0.743 0.940 0.767
ENSG00000186594 E009 28.7755828 0.016824505 0.11566492 0.21377878 17 1711771 1712360 590 - 1.401 1.528 0.437
ENSG00000186594 E010 7.0857505 0.002578193 0.75954769 0.84389083 17 1712361 1712399 39 - 0.883 0.922 0.148
ENSG00000186594 E011 14.1577326 0.019880103 0.37966203 0.52391618 17 1712400 1712588 189 - 1.127 1.231 0.372
ENSG00000186594 E012 7.6839071 0.041564588 0.58203190 0.70646011 17 1712589 1712646 58 - 0.900 0.985 0.317
ENSG00000186594 E013 12.8642427 0.016581510 0.51105541 0.64616226 17 1712647 1712895 249 - 1.106 1.176 0.250
ENSG00000186594 E014 4.0985812 0.004172641 0.40470737 0.54840314 17 1712896 1712904 9 - 0.766 0.654 -0.464
ENSG00000186594 E015 5.4751398 0.003939157 0.64978096 0.76091884 17 1712905 1712925 21 - 0.848 0.796 -0.202
ENSG00000186594 E016 8.7945895 0.002131279 0.26272914 0.40053149 17 1712926 1713055 130 - 1.052 0.940 -0.414
ENSG00000186594 E017 23.8447066 0.001246705 0.23974522 0.37382519 17 1713056 1713702 647 - 1.441 1.369 -0.246
ENSG00000186594 E018 11.6820466 0.037629557 0.07774160 0.15584104 17 1713703 1713855 153 - 1.214 0.972 -0.876
ENSG00000186594 E019 7.0240685 0.015156730 0.01297926 0.03586309 17 1713856 1713902 47 - 1.040 0.717 -1.243
ENSG00000186594 E020 2.3865371 0.008552395 0.62439015 0.74070797 17 1713903 1714014 112 - 0.570 0.492 -0.370
ENSG00000186594 E021 0.5546650 0.028048268 0.48497588 0.62290489 17 1714015 1714045 31 - 0.115 0.231 1.218
ENSG00000186594 E022 0.9158852 0.013809302 0.86690141 0.91834301 17 1714371 1714453 83 - 0.280 0.312 0.213
ENSG00000186594 E023 1.3921999 0.292079943 0.50844359 0.64384955 17 1716130 1716272 143 - 0.280 0.446 0.986
ENSG00000186594 E024 0.0000000       17 1716273 1716341 69 -      
ENSG00000186594 E025 0.1515154 0.048018260 0.57166126   17 1717037 1717174 138 - 0.115 0.000 -8.244