ENSG00000186575

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338641 ENSG00000186575 HEK293_OSMI2_2hA HEK293_TMG_2hB NF2 protein_coding protein_coding 21.6372 32.50481 14.5753 0.3968585 0.3783289 -1.156582 10.4965725 12.60403484 7.01986986 1.85949530 0.62786348 -0.8434599 0.50307083 0.387566667 0.484500000 0.09693333 5.772406e-01 2.078044e-11 FALSE TRUE
ENST00000361452 ENSG00000186575 HEK293_OSMI2_2hA HEK293_TMG_2hB NF2 protein_coding protein_coding 21.6372 32.50481 14.5753 0.3968585 0.3783289 -1.156582 2.0322900 4.53112522 0.33111004 1.33621460 0.21319571 -3.7347407 0.07895417 0.140166667 0.023100000 -0.11706667 1.318817e-01 2.078044e-11 FALSE TRUE
ENST00000397789 ENSG00000186575 HEK293_OSMI2_2hA HEK293_TMG_2hB NF2 protein_coding protein_coding 21.6372 32.50481 14.5753 0.3968585 0.3783289 -1.156582 0.8441783 0.05787546 0.75633869 0.03088163 0.43921875 3.4970201 0.05712083 0.001800000 0.051333333 0.04953333 3.036917e-01 2.078044e-11 FALSE TRUE
ENST00000413209 ENSG00000186575 HEK293_OSMI2_2hA HEK293_TMG_2hB NF2 protein_coding protein_coding 21.6372 32.50481 14.5753 0.3968585 0.3783289 -1.156582 1.9621035 6.15276605 0.06842574 1.73695510 0.06842574 -6.2961069 0.06221250 0.189366667 0.004466667 -0.18490000 1.318982e-03 2.078044e-11 FALSE TRUE
ENST00000672461 ENSG00000186575 HEK293_OSMI2_2hA HEK293_TMG_2hB NF2 protein_coding nonsense_mediated_decay 21.6372 32.50481 14.5753 0.3968585 0.3783289 -1.156582 1.9811785 6.20225364 1.33946228 1.54751723 0.45037011 -2.2027321 0.06929167 0.190166667 0.093566667 -0.09660000 3.197000e-01 2.078044e-11 TRUE TRUE
ENST00000672805 ENSG00000186575 HEK293_OSMI2_2hA HEK293_TMG_2hB NF2 protein_coding nonsense_mediated_decay 21.6372 32.50481 14.5753 0.3968585 0.3783289 -1.156582 1.0291748 0.24217149 1.85820881 0.05592155 0.38320835 2.8891786 0.06266250 0.007466667 0.126366667 0.11890000 2.078044e-11 2.078044e-11 FALSE TRUE
ENST00000672896 ENSG00000186575 HEK293_OSMI2_2hA HEK293_TMG_2hB NF2 protein_coding protein_coding 21.6372 32.50481 14.5753 0.3968585 0.3783289 -1.156582 2.3267931 2.12540950 1.70653112 2.12540950 1.09296649 -0.3150167 0.11131667 0.065166667 0.113400000 0.04823333 5.011826e-01 2.078044e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186575 E001 1.541512 0.0165556210 3.849604e-01 5.291080e-01 22 29603556 29603567 12 + 0.452 0.334 -0.659
ENSG00000186575 E002 3.199065 0.0082178914 1.282130e-01 2.316579e-01 22 29603568 29603587 20 + 0.709 0.521 -0.830
ENSG00000186575 E003 5.346611 0.0955560443 1.596805e-01 2.746919e-01 22 29603588 29603602 15 + 0.896 0.683 -0.848
ENSG00000186575 E004 6.999909 0.1486966273 5.372763e-01 6.688838e-01 22 29603603 29603616 14 + 0.921 0.832 -0.341
ENSG00000186575 E005 10.970921 0.0588306386 6.969316e-02 1.428567e-01 22 29603617 29603632 16 + 1.168 0.959 -0.760
ENSG00000186575 E006 40.283815 0.0346985407 1.363816e-01 2.430087e-01 22 29603633 29603726 94 + 1.634 1.544 -0.308
ENSG00000186575 E007 36.403413 0.0195141032 1.171220e-01 2.158380e-01 22 29603727 29603746 20 + 1.580 1.508 -0.249
ENSG00000186575 E008 80.695044 0.0138185451 7.524199e-03 2.257561e-02 22 29603747 29603948 202 + 1.948 1.832 -0.390
ENSG00000186575 E009 50.636239 0.0124123018 6.146254e-03 1.899493e-02 22 29603949 29603998 50 + 1.761 1.627 -0.456
ENSG00000186575 E010 72.014662 0.0176667943 4.017272e-06 2.920863e-05 22 29603999 29604085 87 + 1.999 1.722 -0.933
ENSG00000186575 E011 62.653863 0.0250141450 2.146211e-05 1.321009e-04 22 29604086 29604112 27 + 1.951 1.653 -1.007
ENSG00000186575 E012 7.162796 0.0198147809 8.073321e-07 6.838967e-06 22 29628658 29628773 116 + 1.194 0.605 -2.275
ENSG00000186575 E013 120.479580 0.0076434204 4.494871e-10 7.102379e-09 22 29636751 29636876 126 + 2.210 1.950 -0.870
ENSG00000186575 E014 106.741459 0.0127158453 1.861225e-07 1.794054e-06 22 29639090 29639212 123 + 2.160 1.899 -0.878
ENSG00000186575 E015 87.492724 0.0068741233 6.908951e-07 5.938927e-06 22 29642202 29642285 84 + 2.041 1.836 -0.691
ENSG00000186575 E016 88.422843 0.0046403657 3.818519e-06 2.791137e-05 22 29654657 29654725 69 + 2.021 1.855 -0.558
ENSG00000186575 E017 0.147249 0.0429578246 2.118682e-01   22 29654975 29655080 106 + 0.164 0.000 -9.509
ENSG00000186575 E018 98.978857 0.0044016430 3.571284e-07 3.252735e-06 22 29655594 29655676 83 + 2.076 1.899 -0.595
ENSG00000186575 E019 111.744116 0.0043482689 1.340055e-09 1.939414e-08 22 29658189 29658264 76 + 2.149 1.936 -0.715
ENSG00000186575 E020 167.828909 0.0045573301 4.982572e-07 4.407608e-06 22 29661205 29661339 135 + 2.286 2.137 -0.496
ENSG00000186575 E021 135.000603 0.0036570172 7.024613e-04 2.907945e-03 22 29664990 29665064 75 + 2.148 2.067 -0.268
ENSG00000186575 E022 174.847735 0.0041332230 5.540670e-03 1.739235e-02 22 29668333 29668446 114 + 2.241 2.190 -0.171
ENSG00000186575 E023 156.102149 0.0019191346 6.432319e-04 2.691753e-03 22 29671826 29671912 87 + 2.197 2.140 -0.191
ENSG00000186575 E024 119.890658 0.0002651163 1.701170e-04 8.355105e-04 22 29671913 29671948 36 + 2.087 2.025 -0.210
ENSG00000186575 E025 223.032735 0.0010256618 1.804566e-03 6.613590e-03 22 29673269 29673486 218 + 2.329 2.306 -0.078
ENSG00000186575 E026 156.958781 0.0002963942 3.646134e-03 1.214415e-02 22 29674836 29674941 106 + 2.175 2.153 -0.076
ENSG00000186575 E027 187.022923 0.0003180577 1.028054e-04 5.350303e-04 22 29678196 29678323 128 + 2.263 2.220 -0.144
ENSG00000186575 E028 190.456092 0.0002291130 4.092168e-05 2.353381e-04 22 29681439 29681601 163 + 2.274 2.227 -0.156
ENSG00000186575 E029 44.924692 0.0005118944 7.807154e-01 8.591071e-01 22 29683020 29683064 45 + 1.586 1.635 0.167
ENSG00000186575 E030 2.216471 0.0068769546 2.360159e-01 3.695615e-01 22 29683065 29683079 15 + 0.574 0.418 -0.760
ENSG00000186575 E031 4.347002 0.0036773381 8.538880e-01 9.096041e-01 22 29683080 29683700 621 + 0.669 0.693 0.105
ENSG00000186575 E032 5.582001 0.1054059736 2.686590e-01 4.071406e-01 22 29683701 29684162 462 + 0.870 0.724 -0.578
ENSG00000186575 E033 301.281237 0.0002201758 1.045034e-02 2.986464e-02 22 29694752 29695243 492 + 2.432 2.441 0.029
ENSG00000186575 E034 986.062865 0.0002966583 1.809325e-22 1.521399e-20 22 29695244 29697260 2017 + 2.802 3.004 0.671
ENSG00000186575 E035 1330.052478 0.0098616258 1.179073e-20 8.158212e-19 22 29697261 29698598 1338 + 2.721 3.177 1.516