ENSG00000186566

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000591680 ENSG00000186566 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH8 protein_coding protein_coding 15.44243 12.06783 18.97985 0.4928729 0.1893902 0.6528673 14.04109 11.79164 17.29736 0.5400315 0.2255403 0.5523985 0.9165208 0.9767667 0.9114667 -0.0653 0.01263812 0.01263812 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186566 E001 1.4714926 0.0192358836 3.060566e-03 1.044430e-02 17 44395281 44395283 3 - 0.096 0.645 3.789
ENSG00000186566 E002 676.8532815 0.0051728278 1.894062e-26 2.337618e-24 17 44395284 44396573 1290 - 2.607 3.018 1.367
ENSG00000186566 E003 425.5927586 0.0020620307 1.224240e-21 9.370855e-20 17 44396574 44397345 772 - 2.463 2.779 1.052
ENSG00000186566 E004 92.1335684 0.0022128000 2.403949e-03 8.473467e-03 17 44397346 44397415 70 - 1.867 2.065 0.663
ENSG00000186566 E005 1124.5006824 0.0001213422 9.298736e-04 3.718925e-03 17 44397416 44400337 2922 - 3.027 3.064 0.122
ENSG00000186566 E006 287.8834325 0.0032689841 2.840993e-10 4.642608e-09 17 44400338 44401041 704 - 2.505 2.362 -0.476
ENSG00000186566 E007 130.9251494 0.0066257476 1.547553e-06 1.233141e-05 17 44401042 44401336 295 - 2.174 2.000 -0.583
ENSG00000186566 E008 73.4526799 0.0003972543 1.900383e-08 2.225241e-07 17 44401337 44401407 71 - 1.927 1.750 -0.595
ENSG00000186566 E009 67.9671404 0.0018192768 1.564657e-08 1.859712e-07 17 44401408 44401453 46 - 1.905 1.694 -0.711
ENSG00000186566 E010 96.4649872 0.0003125827 4.508173e-15 1.562495e-13 17 44405921 44406051 131 - 2.062 1.829 -0.785
ENSG00000186566 E011 0.5181333 0.0205678401 8.154845e-01 8.831778e-01 17 44407217 44407266 50 - 0.174 0.155 -0.204
ENSG00000186566 E012 57.3028899 0.0005057184 2.341032e-06 1.794261e-05 17 44424349 44424376 28 - 1.818 1.655 -0.553
ENSG00000186566 E013 90.5407340 0.0003348168 6.655969e-10 1.020602e-08 17 44424377 44424492 116 - 2.016 1.842 -0.584
ENSG00000186566 E014 51.4460991 0.0025994349 1.740339e-04 8.527805e-04 17 44435065 44435068 4 - 1.764 1.621 -0.485
ENSG00000186566 E015 82.2026713 0.0004729665 6.629973e-07 5.723268e-06 17 44435069 44435151 83 - 1.962 1.826 -0.459
ENSG00000186566 E016 60.2228237 0.0024716283 9.799262e-08 9.967467e-07 17 44436478 44436506 29 - 1.857 1.642 -0.728
ENSG00000186566 E017 57.4927074 0.0095822566 6.106189e-05 3.367291e-04 17 44436507 44436545 39 - 1.833 1.629 -0.688
ENSG00000186566 E018 0.6060617 0.8946620947 4.394483e-01 5.812075e-01 17 44436546 44436787 242 - 0.301 0.000 -10.853
ENSG00000186566 E019 0.5891098 0.0183636485 8.561577e-02 1.683834e-01 17 44438671 44438715 45 - 0.299 0.000 -12.149
ENSG00000186566 E020 0.1451727 0.0431674517 6.957789e-01   17 44445755 44445922 168 - 0.096 0.000 -9.828
ENSG00000186566 E021 74.4265332 0.0003496246 1.989536e-14 6.265152e-13 17 44464472 44464544 73 - 1.960 1.690 -0.910
ENSG00000186566 E022 2.4840053 0.0062434424 1.546828e-02 4.155548e-02 17 44464545 44465935 1391 - 0.649 0.269 -2.013
ENSG00000186566 E023 2.7471805 0.0070086007 1.095959e-01 2.049758e-01 17 44467097 44467114 18 - 0.649 0.433 -1.015
ENSG00000186566 E024 1.2296269 0.2513302328 1.980374e-01 3.237681e-01 17 44467115 44467202 88 - 0.437 0.155 -2.016
ENSG00000186566 E025 1.0371996 0.0174953716 1.487047e-02 4.019814e-02 17 44473290 44473724 435 - 0.436 0.000 -12.961
ENSG00000186566 E026 0.9672673 0.0150707403 7.285374e-01 8.209800e-01 17 44473725 44473759 35 - 0.299 0.269 -0.206
ENSG00000186566 E027 1.6993717 0.0086537478 7.901612e-01 8.657918e-01 17 44474420 44474828 409 - 0.436 0.433 -0.015
ENSG00000186566 E028 72.1399154 0.0003318553 1.918079e-14 6.059267e-13 17 44474829 44474903 75 - 1.949 1.675 -0.927
ENSG00000186566 E029 55.2522507 0.0004122816 3.056929e-11 5.879453e-10 17 44503326 44503444 119 - 1.834 1.563 -0.919