ENSG00000186472

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333891 ENSG00000186472 HEK293_OSMI2_2hA HEK293_TMG_2hB PCLO protein_coding protein_coding 1.400617 1.341741 1.298286 0.2544932 0.1271206 -0.04714088 0.1124521 0.05518809 0.23896390 0.01086330 0.04063943 1.9332562 0.0855000 0.04143333 0.18560000 0.1441667 0.0179555634 0.0001476091 FALSE TRUE
ENST00000423517 ENSG00000186472 HEK293_OSMI2_2hA HEK293_TMG_2hB PCLO protein_coding protein_coding 1.400617 1.341741 1.298286 0.2544932 0.1271206 -0.04714088 0.3908778 0.23904930 0.41783428 0.05020604 0.04907937 0.7806208 0.2981792 0.17653333 0.33373333 0.1572000 0.2492710633 0.0001476091 FALSE TRUE
ENST00000437081 ENSG00000186472 HEK293_OSMI2_2hA HEK293_TMG_2hB PCLO protein_coding protein_coding 1.400617 1.341741 1.298286 0.2544932 0.1271206 -0.04714088 0.4235837 0.62228337 0.16103749 0.10907752 0.06849662 -1.8862586 0.2843208 0.46600000 0.11813333 -0.3478667 0.0001476091 0.0001476091 FALSE TRUE
ENST00000618073 ENSG00000186472 HEK293_OSMI2_2hA HEK293_TMG_2hB PCLO protein_coding protein_coding 1.400617 1.341741 1.298286 0.2544932 0.1271206 -0.04714088 0.1794395 0.34022570 0.08591658 0.07215468 0.08591658 -1.8684329 0.1107250 0.25076667 0.05533333 -0.1954333 0.1961807321 0.0001476091 FALSE TRUE
MSTRG.30158.4 ENSG00000186472 HEK293_OSMI2_2hA HEK293_TMG_2hB PCLO protein_coding   1.400617 1.341741 1.298286 0.2544932 0.1271206 -0.04714088 0.2060892 0.05206983 0.34232511 0.05206983 0.04240232 2.5049432 0.1618250 0.02906667 0.26253333 0.2334667 0.0010485425 0.0001476091 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186472 E001 25.1778748 0.0095127210 1.493269e-02 4.033296e-02 7 82754012 82758715 4704 - 1.506 1.282 -0.774
ENSG00000186472 E002 2.0659776 0.0081863616 1.972129e-01 3.227404e-01 7 82760639 82760784 146 - 0.573 0.334 -1.244
ENSG00000186472 E003 1.8037449 0.0085091285 7.949523e-01 8.690299e-01 7 82761359 82761493 135 - 0.465 0.406 -0.314
ENSG00000186472 E004 1.3359615 0.0609871998 9.015860e-01 9.412903e-01 7 82801518 82801536 19 - 0.375 0.335 -0.239
ENSG00000186472 E005 1.3359615 0.0609871998 9.015860e-01 9.412903e-01 7 82801537 82801591 55 - 0.375 0.335 -0.239
ENSG00000186472 E006 0.7458221 0.0198770219 3.431227e-01 4.871809e-01 7 82805688 82805736 49 - 0.322 0.142 -1.510
ENSG00000186472 E007 1.2305573 0.0903188856 4.251961e-01 5.681367e-01 7 82805737 82805829 93 - 0.423 0.248 -1.102
ENSG00000186472 E008 19.2971908 0.0014528749 1.027060e-04 5.345422e-04 7 82820477 82821111 635 - 1.151 1.429 0.974
ENSG00000186472 E009 12.5939016 0.0373302074 1.195999e-02 3.343393e-02 7 82821112 82821294 183 - 0.965 1.260 1.064
ENSG00000186472 E010 20.1845634 0.0179630142 7.210583e-06 4.949726e-05 7 82821295 82822096 802 - 1.078 1.492 1.455
ENSG00000186472 E011 1.8779411 0.0084234080 7.288479e-01 8.212183e-01 7 82822097 82822108 12 - 0.423 0.467 0.231
ENSG00000186472 E012 8.1607280 0.0023030556 9.379260e-01 9.650099e-01 7 82822109 82822494 386 - 0.952 0.941 -0.043
ENSG00000186472 E013 11.0876212 0.0264279713 9.252350e-01 9.569385e-01 7 82822495 82822689 195 - 1.069 1.065 -0.014
ENSG00000186472 E014 9.0274211 0.0019691324 6.148142e-01 7.332140e-01 7 82824236 82824416 181 - 0.978 1.011 0.123
ENSG00000186472 E015 5.3424123 0.0039068064 3.502695e-01 4.944636e-01 7 82826589 82826660 72 - 0.753 0.856 0.404
ENSG00000186472 E016 4.5578699 0.0385389743 6.769829e-01 7.818027e-01 7 82827873 82827966 94 - 0.731 0.777 0.184
ENSG00000186472 E017 0.1482932 0.0456572363 3.335722e-01   7 82835667 82835693 27 - 0.000 0.141 9.966
ENSG00000186472 E018 4.8973161 0.0034809025 7.358083e-02 1.492566e-01 7 82838218 82838342 125 - 0.660 0.878 0.878
ENSG00000186472 E019 4.9384064 0.0035123794 9.723691e-01 9.867606e-01 7 82841459 82841509 51 - 0.774 0.751 -0.092
ENSG00000186472 E020 7.5192170 0.0023030772 2.475259e-01 3.830384e-01 7 82845271 82845426 156 - 0.864 0.978 0.429
ENSG00000186472 E021 3.7818454 0.0116191759 7.769163e-01 8.563808e-01 7 82845427 82845485 59 - 0.660 0.687 0.116
ENSG00000186472 E022 4.0011151 0.0188818155 9.592087e-01 9.784474e-01 7 82846567 82846634 68 - 0.709 0.687 -0.091
ENSG00000186472 E023 3.2346560 0.0050853271 6.295177e-01 7.448772e-01 7 82847139 82847146 8 - 0.660 0.569 -0.400
ENSG00000186472 E024 6.2038569 0.0046554037 8.277010e-01 8.916900e-01 7 82847147 82847247 101 - 0.847 0.856 0.034
ENSG00000186472 E025 0.1472490 0.0428241120 7.000047e-01   7 82848868 82848921 54 - 0.105 0.000 -10.437
ENSG00000186472 E026 0.4751703 0.0210323669 3.631484e-01 5.075799e-01 7 82868107 82868195 89 - 0.105 0.248 1.491
ENSG00000186472 E027 6.7442421 0.0025119182 5.455035e-01 6.758264e-01 7 82879337 82879462 126 - 0.925 0.832 -0.356
ENSG00000186472 E028 0.0000000       7 82894397 82894454 58 -      
ENSG00000186472 E029 7.2178166 0.0124431974 3.703955e-01 5.148263e-01 7 82902651 82902732 82 - 0.966 0.832 -0.507
ENSG00000186472 E030 4.6410438 0.0237341836 7.741020e-02 1.553033e-01 7 82902733 82902741 9 - 0.864 0.568 -1.228
ENSG00000186472 E031 7.3974210 0.0025391131 7.365656e-02 1.493846e-01 7 82908877 82909013 137 - 1.014 0.779 -0.895
ENSG00000186472 E032 8.1267621 0.0031217934 3.198056e-09 4.317103e-08 7 82914361 82914685 325 - 0.466 1.185 2.898
ENSG00000186472 E033 79.9715725 0.0004400667 1.041049e-09 1.538886e-08 7 82914686 82916873 2188 - 1.798 1.996 0.668
ENSG00000186472 E034 42.1369977 0.0031244728 3.994421e-01 5.431876e-01 7 82949476 82951490 2015 - 1.658 1.591 -0.229
ENSG00000186472 E035 52.3743805 0.0159496835 4.395559e-07 3.931103e-06 7 82951856 82956935 5080 - 1.862 1.475 -1.316
ENSG00000186472 E036 6.7454411 0.0150269332 1.599879e-03 5.960868e-03 7 82965771 82966420 650 - 1.036 0.570 -1.863
ENSG00000186472 E037 2.7167145 0.0883186970 4.222105e-03 1.376372e-02 7 82966421 82966487 67 - 0.752 0.142 -3.583
ENSG00000186472 E038 12.6877653 0.0017374296 8.298787e-05 4.421578e-04 7 83134250 83135656 1407 - 1.275 0.856 -1.529
ENSG00000186472 E039 12.8540170 0.0653119621 3.668450e-03 1.220585e-02 7 83154748 83156392 1645 - 1.298 0.833 -1.699
ENSG00000186472 E040 4.4853874 0.0540874766 2.836533e-01 4.238022e-01 7 83162345 83162930 586 - 0.813 0.614 -0.823