ENSG00000186432

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334256 ENSG00000186432 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA4 protein_coding protein_coding 23.38246 9.054883 39.2509 0.1298711 1.675867 2.114733 1.945770 1.062073 2.775721 0.08216728 0.2641541 1.377648 0.1133708 0.1172667 0.07113333 -0.04613333 7.872036e-02 7.13159e-47 FALSE TRUE
ENST00000483437 ENSG00000186432 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA4 protein_coding protein_coding 23.38246 9.054883 39.2509 0.1298711 1.675867 2.114733 5.521719 0.000000 10.385287 0.00000000 0.3729483 10.021714 0.1543250 0.0000000 0.26483333 0.26483333 7.131590e-47 7.13159e-47 FALSE TRUE
ENST00000676799 ENSG00000186432 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA4 protein_coding nonsense_mediated_decay 23.38246 9.054883 39.2509 0.1298711 1.675867 2.114733 8.442381 3.788422 14.296352 0.26663917 0.2359776 1.913184 0.3996000 0.4194000 0.36533333 -0.05406667 5.450683e-01 7.13159e-47 FALSE TRUE
ENST00000678765 ENSG00000186432 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA4 protein_coding protein_coding 23.38246 9.054883 39.2509 0.1298711 1.675867 2.114733 6.288979 3.257047 10.592798 0.11755204 1.1375247 1.698386 0.2717792 0.3596000 0.26833333 -0.09126667 7.688741e-02 7.13159e-47 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186432 E001 241.5969782 0.0058818590 5.638838e-05 3.135765e-04 3 160495007 160500172 5166 - 2.246 2.478 0.773
ENSG00000186432 E002 11.9072978 0.0046494838 5.569198e-01 6.854648e-01 3 160500173 160500192 20 - 1.015 1.130 0.416
ENSG00000186432 E003 30.8494713 0.0013723893 1.559395e-03 5.827451e-03 3 160500193 160500208 16 - 1.357 1.627 0.925
ENSG00000186432 E004 915.8255419 0.0056567061 5.066080e-07 4.477716e-06 3 160500209 160502039 1831 - 2.830 3.037 0.690
ENSG00000186432 E005 159.6030800 0.0002830665 7.998414e-01 8.723471e-01 3 160502040 160502202 163 - 2.114 2.177 0.210
ENSG00000186432 E006 0.6256415 0.0175637599 8.772768e-01 9.251625e-01 3 160504001 160504067 67 - 0.171 0.219 0.442
ENSG00000186432 E007 162.3804226 0.0002351418 5.022382e-01 6.382998e-01 3 160504958 160505052 95 - 2.129 2.161 0.108
ENSG00000186432 E008 2.3702681 0.1351404495 5.217587e-01 6.556489e-01 3 160505053 160507354 2302 - 0.491 0.369 -0.649
ENSG00000186432 E009 199.0969387 0.0002285670 5.105193e-01 6.457184e-01 3 160508107 160508269 163 - 2.217 2.251 0.117
ENSG00000186432 E010 151.5741547 0.0002433036 6.334353e-01 7.481447e-01 3 160509800 160509871 72 - 2.099 2.137 0.128
ENSG00000186432 E011 1.7927004 0.0571040611 3.891528e-02 8.902769e-02 3 160513250 160514076 827 - 0.468 0.001 -10.245
ENSG00000186432 E012 178.3526153 0.0082889696 2.549375e-01 3.917171e-01 3 160514077 160514181 105 - 2.180 2.173 -0.022
ENSG00000186432 E013 210.6324916 0.0002149394 1.096618e-04 5.664338e-04 3 160515452 160515580 129 - 2.263 2.202 -0.204
ENSG00000186432 E014 216.5248760 0.0001895362 3.999518e-06 2.910077e-05 3 160521779 160521910 132 - 2.279 2.197 -0.274
ENSG00000186432 E015 0.6266857 0.0166652268 2.188398e-01 3.490187e-01 3 160521911 160522861 951 - 0.121 0.364 2.025
ENSG00000186432 E016 0.6256415 0.0175637599 8.772768e-01 9.251625e-01 3 160525021 160525132 112 - 0.171 0.219 0.442
ENSG00000186432 E017 134.7187113 0.0002673560 1.158576e-05 7.586744e-05 3 160525800 160525844 45 - 2.081 1.968 -0.380
ENSG00000186432 E018 199.5488441 0.0002358155 1.374726e-04 6.924695e-04 3 160525938 160526107 170 - 2.241 2.178 -0.209
ENSG00000186432 E019 139.1875899 0.0002677433 6.298414e-02 1.316812e-01 3 160527953 160528039 87 - 2.074 2.062 -0.042
ENSG00000186432 E020 140.1026615 0.0008815982 2.319944e-02 5.816270e-02 3 160530855 160530940 86 - 2.081 2.049 -0.107
ENSG00000186432 E021 154.0888409 0.0002955380 1.120817e-02 3.166586e-02 3 160531462 160531557 96 - 2.122 2.088 -0.112
ENSG00000186432 E022 126.8547300 0.0002680501 1.642378e-02 4.366499e-02 3 160535513 160535565 53 - 2.038 2.001 -0.125
ENSG00000186432 E023 104.2354683 0.0002732491 8.727722e-03 2.560497e-02 3 160535661 160535690 30 - 1.959 1.902 -0.191
ENSG00000186432 E024 135.4012344 0.0002653049 1.647192e-05 1.041435e-04 3 160535808 160535897 90 - 2.081 1.971 -0.369
ENSG00000186432 E025 102.0607204 0.0003966465 6.795738e-05 3.703243e-04 3 160536796 160536840 45 - 1.963 1.841 -0.412
ENSG00000186432 E026 4.2422140 0.1630307345 2.056471e-03 7.400224e-03 3 160564209 160564504 296 - 0.359 1.109 3.203
ENSG00000186432 E027 1.8528592 0.1332456945 7.685648e-04 3.145271e-03 3 160564505 160564520 16 - 0.121 0.835 4.177
ENSG00000186432 E028 5.2451712 0.0519786160 6.076077e-04 2.560890e-03 3 160564521 160564640 120 - 0.513 1.123 2.442
ENSG00000186432 E029 125.8434811 0.0008787735 2.831916e-04 1.311411e-03 3 160565214 160565571 358 - 2.048 1.953 -0.320