ENSG00000186318

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313005 ENSG00000186318 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE1 protein_coding protein_coding 13.18611 11.35269 14.73839 1.28538 0.7762574 0.3762521 4.4351714 3.1075827 6.4109935 1.26657177 0.6505494 1.0423687 0.32897083 0.26090000 0.43616667 0.17526667 0.462324497 0.001155839 FALSE TRUE
ENST00000392937 ENSG00000186318 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE1 protein_coding protein_coding 13.18611 11.35269 14.73839 1.28538 0.7762574 0.3762521 0.8031882 1.4979830 0.8534349 1.49798296 0.7457150 -0.8044608 0.07777500 0.16093333 0.06146667 -0.09946667 0.797912853 0.001155839 FALSE TRUE
ENST00000528053 ENSG00000186318 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE1 protein_coding protein_coding 13.18611 11.35269 14.73839 1.28538 0.7762574 0.3762521 1.1226145 1.5953647 0.9573916 0.80742213 0.5652215 -0.7307292 0.08742083 0.14130000 0.06903333 -0.07226667 0.893224829 0.001155839 FALSE TRUE
ENST00000680681 ENSG00000186318 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE1 protein_coding protein_coding 13.18611 11.35269 14.73839 1.28538 0.7762574 0.3762521 2.0795710 2.1553888 1.0595175 0.64979469 0.5367924 -1.0176660 0.16255417 0.18916667 0.06930000 -0.11986667 0.540753972 0.001155839 FALSE TRUE
ENST00000681753 ENSG00000186318 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE1 protein_coding processed_transcript 13.18611 11.35269 14.73839 1.28538 0.7762574 0.3762521 2.3104469 1.5293903 2.4919355 0.82961958 0.5704686 0.7006855 0.16339583 0.12176667 0.16606667 0.04430000 0.795715642 0.001155839 FALSE TRUE
MSTRG.6381.17 ENSG00000186318 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE1 protein_coding   13.18611 11.35269 14.73839 1.28538 0.7762574 0.3762521 0.5380803 0.1226277 1.0247466 0.07990419 0.1861734 2.9638234 0.03806667 0.01003333 0.06910000 0.05906667 0.001155839 0.001155839 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186318 E001 3.0906135 0.0311603138 0.740412596 0.829849091 11 117285232 117285697 466 - 0.563 0.628 0.289
ENSG00000186318 E002 1.4308980 0.0150307696 0.451300181 0.592284591 11 117285698 117285705 8 - 0.443 0.317 -0.722
ENSG00000186318 E003 251.1204642 0.0082742880 0.380997631 0.525276384 11 117285706 117287350 1645 - 2.413 2.390 -0.079
ENSG00000186318 E004 17.5363144 0.0232236856 0.179785297 0.300897444 11 117287351 117287411 61 - 1.331 1.202 -0.452
ENSG00000186318 E005 455.7068807 0.0081315774 0.005005011 0.015943374 11 117287412 117289012 1601 - 2.593 2.718 0.416
ENSG00000186318 E006 145.1908049 0.0002880185 0.014638911 0.039682030 11 117289013 117289270 258 - 2.119 2.204 0.284
ENSG00000186318 E007 149.4875294 0.0013819985 0.024365463 0.060572979 11 117289271 117289486 216 - 2.131 2.219 0.295
ENSG00000186318 E008 69.9591699 0.0038777549 0.312338471 0.454882622 11 117289487 117289534 48 - 1.816 1.883 0.226
ENSG00000186318 E009 151.2810053 0.0033706510 0.190790199 0.314738073 11 117289535 117289807 273 - 2.147 2.214 0.223
ENSG00000186318 E010 2.1881579 0.1392991323 0.841914849 0.901430676 11 117289808 117290459 652 - 0.488 0.538 0.243
ENSG00000186318 E011 0.5944058 0.3352008510 0.559397814 0.687501136 11 117290460 117290487 28 - 0.113 0.242 1.333
ENSG00000186318 E012 57.0314645 0.0004927850 0.275342210 0.414638409 11 117290488 117290502 15 - 1.781 1.744 -0.125
ENSG00000186318 E013 127.7003442 0.0002445714 0.284333620 0.424564144 11 117290503 117290633 131 - 2.116 2.097 -0.065
ENSG00000186318 E014 69.3485067 0.0036142916 0.774124001 0.854351815 11 117290634 117290659 26 - 1.842 1.842 -0.003
ENSG00000186318 E015 0.0000000       11 117290660 117290899 240 -      
ENSG00000186318 E016 120.4831675 0.0072375049 0.939113801 0.965765366 11 117290900 117291049 150 - 2.076 2.086 0.034
ENSG00000186318 E017 0.1817044 0.0394748320 0.419270615   11 117291050 117291711 662 - 0.000 0.133 11.117
ENSG00000186318 E018 93.4611949 0.0119782120 0.417610308 0.560939130 11 117291712 117291813 102 - 1.991 1.953 -0.126
ENSG00000186318 E019 2.0231269 0.0084145460 0.768550635 0.850414193 11 117291814 117292958 1145 - 0.487 0.446 -0.206
ENSG00000186318 E020 0.1451727 0.0435094873 0.565541448   11 117292959 117293016 58 - 0.112 0.000 -10.836
ENSG00000186318 E021 0.2924217 0.0272485309 0.247529507   11 117293017 117293053 37 - 0.202 0.000 -11.836
ENSG00000186318 E022 106.7282971 0.0042427490 0.116327456 0.214716793 11 117293054 117293188 135 - 2.056 1.999 -0.192
ENSG00000186318 E023 14.1503972 0.0052744354 0.998272990 1.000000000 11 117293189 117293870 682 - 1.164 1.177 0.044
ENSG00000186318 E024 66.8796108 0.0003960669 0.017072334 0.045096871 11 117293871 117293933 63 - 1.871 1.782 -0.301
ENSG00000186318 E025 58.5826034 0.0004481569 0.535180583 0.667112397 11 117293934 117294008 75 - 1.783 1.768 -0.050
ENSG00000186318 E026 4.1081567 0.0064340352 0.842979626 0.902188308 11 117294009 117294441 433 - 0.685 0.724 0.162
ENSG00000186318 E027 83.7385562 0.0004646423 0.025437441 0.062784795 11 117295131 117295262 132 - 1.960 1.886 -0.246
ENSG00000186318 E028 55.0580258 0.0004894017 0.007575249 0.022707407 11 117295263 117295318 56 - 1.798 1.684 -0.385
ENSG00000186318 E029 43.9483257 0.0079061044 0.078545084 0.157155703 11 117295319 117295347 29 - 1.697 1.594 -0.351
ENSG00000186318 E030 0.0000000       11 117295430 117295485 56 -      
ENSG00000186318 E031 0.2955422 0.0300002702 0.907734852   11 117295498 117295636 139 - 0.112 0.133 0.275
ENSG00000186318 E032 54.9350577 0.0023671382 0.001198392 0.004634909 11 117296873 117296961 89 - 1.814 1.658 -0.526
ENSG00000186318 E033 1.5499432 0.0090538106 0.054080931 0.116392731 11 117299648 117299696 49 - 0.202 0.545 2.085
ENSG00000186318 E034 2.2466327 0.1654173361 0.120297105 0.220403691 11 117300671 117300737 67 - 0.275 0.638 1.919
ENSG00000186318 E035 113.8774225 0.0170081743 0.049004847 0.107388245 11 117315535 117316259 725 - 2.110 2.000 -0.368