ENSG00000186298

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335007 ENSG00000186298 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1CC protein_coding protein_coding 138.4704 69.86175 219.8119 10.44056 8.767305 1.653554 98.777247 60.3022694 144.63475 8.46836748 5.312144 1.261991 0.75061250 0.86563333 0.65813333 -0.2075000 1.024116e-10 1.458135e-102 FALSE TRUE
ENST00000340766 ENSG00000186298 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1CC protein_coding protein_coding 138.4704 69.86175 219.8119 10.44056 8.767305 1.653554 7.590981 1.4735793 15.13573 0.86923892 1.516664 3.351757 0.05584167 0.02406667 0.06916667 0.0451000 1.157072e-01 1.458135e-102 FALSE TRUE
ENST00000550261 ENSG00000186298 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1CC protein_coding nonsense_mediated_decay 138.4704 69.86175 219.8119 10.44056 8.767305 1.653554 1.010403 4.1972656 0.00000 2.12392546 0.000000 -8.716739 0.01362083 0.05600000 0.00000000 -0.0560000 7.285053e-02 1.458135e-102 FALSE TRUE
MSTRG.8013.12 ENSG00000186298 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1CC protein_coding   138.4704 69.86175 219.8119 10.44056 8.767305 1.653554 19.780768 0.3092688 38.81903 0.07330448 2.177165 6.926220 0.09116667 0.00440000 0.17636667 0.1719667 1.458135e-102 1.458135e-102 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186298 E001 22.159998 8.494595e-04 6.699580e-09 8.532540e-08 12 110708803 110708962 160 - 1.146 1.591 1.546
ENSG00000186298 E002 13.052674 1.382631e-03 3.907815e-03 1.288528e-02 12 110708963 110709034 72 - 1.012 1.301 1.031
ENSG00000186298 E003 10.926869 6.330090e-03 9.715623e-04 3.861524e-03 12 110715002 110715147 146 - 0.904 1.265 1.312
ENSG00000186298 E004 257.446803 2.975051e-03 5.729178e-17 2.536517e-15 12 110719680 110719907 228 - 2.259 2.576 1.056
ENSG00000186298 E005 593.356273 5.111560e-03 1.162494e-11 2.394075e-10 12 110719908 110719982 75 - 2.636 2.917 0.935
ENSG00000186298 E006 1468.848290 3.242820e-03 9.071884e-16 3.449009e-14 12 110719983 110720204 222 - 3.046 3.288 0.805
ENSG00000186298 E007 996.372787 5.210189e-04 8.931060e-23 7.732919e-21 12 110720205 110720365 161 - 2.911 3.085 0.578
ENSG00000186298 E008 1745.399516 1.010712e-04 9.699058e-17 4.176989e-15 12 110720366 110720729 364 - 3.183 3.283 0.332
ENSG00000186298 E009 519.327847 1.379266e-03 2.785361e-01 4.182148e-01 12 110720730 110720747 18 - 2.677 2.719 0.138
ENSG00000186298 E010 1018.388335 7.521091e-05 3.164466e-01 4.592065e-01 12 110720748 110720920 173 - 2.973 3.007 0.112
ENSG00000186298 E011 1196.909933 8.025973e-04 3.848397e-01 5.289908e-01 12 110720921 110721104 184 - 3.053 3.054 0.004
ENSG00000186298 E012 856.498046 1.519455e-03 8.886748e-01 9.328217e-01 12 110721105 110721165 61 - 2.904 2.914 0.033
ENSG00000186298 E013 9.545546 1.967870e-03 7.403353e-01 8.297746e-01 12 110721301 110721769 469 - 0.976 1.032 0.205
ENSG00000186298 E014 19.080939 1.277877e-03 4.342553e-07 3.887735e-06 12 110721770 110722134 365 - 1.106 1.522 1.457
ENSG00000186298 E015 1136.946836 6.191993e-04 1.462615e-02 3.965311e-02 12 110722135 110722269 135 - 3.038 3.014 -0.079
ENSG00000186298 E016 35.040447 5.827936e-04 7.793221e-03 2.325702e-02 12 110722270 110722471 202 - 1.579 1.426 -0.526
ENSG00000186298 E017 1066.783540 9.208541e-05 6.322195e-08 6.672540e-07 12 110722472 110722623 152 - 3.018 2.973 -0.150
ENSG00000186298 E018 785.363622 1.119149e-04 3.401924e-15 1.200157e-13 12 110722624 110722695 72 - 2.899 2.807 -0.309
ENSG00000186298 E019 946.572837 2.077448e-04 7.213573e-20 4.499802e-18 12 110724660 110724764 105 - 2.984 2.875 -0.365
ENSG00000186298 E020 3.866541 8.153516e-02 9.472217e-01 9.708479e-01 12 110724765 110726679 1915 - 0.673 0.699 0.109
ENSG00000186298 E021 1.624233 8.356113e-03 1.098877e-02 3.113609e-02 12 110730525 110730528 4 - 0.515 0.000 -11.622
ENSG00000186298 E022 933.504513 1.528973e-04 8.652585e-20 5.358635e-18 12 110730529 110730650 122 - 2.978 2.873 -0.350
ENSG00000186298 E023 1021.124503 6.697175e-04 7.405055e-20 4.616208e-18 12 110730651 110730759 109 - 3.026 2.886 -0.463
ENSG00000186298 E024 701.372904 2.801657e-03 3.276114e-11 6.269191e-10 12 110731770 110731815 46 - 2.873 2.688 -0.615
ENSG00000186298 E025 781.860756 1.678543e-03 4.198268e-12 9.296894e-11 12 110731816 110731901 86 - 2.912 2.757 -0.518
ENSG00000186298 E026 3.893259 9.275088e-02 6.991684e-01 7.989779e-01 12 110731902 110732983 1082 - 0.693 0.610 -0.353
ENSG00000186298 E027 1.951122 2.652483e-02 6.089941e-01 7.285708e-01 12 110734718 110734986 269 - 0.486 0.404 -0.426
ENSG00000186298 E028 3.796697 4.036259e-03 9.564748e-01 9.767269e-01 12 110735940 110736021 82 - 0.654 0.662 0.035
ENSG00000186298 E029 556.214465 3.982670e-03 1.006185e-09 1.491539e-08 12 110742653 110742939 287 - 2.777 2.569 -0.692