ENSG00000186166

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334418 ENSG00000186166 HEK293_OSMI2_2hA HEK293_TMG_2hB CENATAC protein_coding protein_coding 11.38946 12.01934 7.376644 1.145919 0.1961736 -0.7035665 2.2828259 2.8349178 2.7975737 0.48195727 0.11288447 -0.01906304 0.27446250 0.23270000 0.38060000 0.14790000 0.02155061 0.01023277 FALSE TRUE
ENST00000527356 ENSG00000186166 HEK293_OSMI2_2hA HEK293_TMG_2hB CENATAC protein_coding retained_intron 11.38946 12.01934 7.376644 1.145919 0.1961736 -0.7035665 0.6360172 0.4902757 0.4517361 0.07901086 0.12007391 -0.11565493 0.05327083 0.04163333 0.06213333 0.02050000 0.70160989 0.01023277 TRUE TRUE
ENST00000528088 ENSG00000186166 HEK293_OSMI2_2hA HEK293_TMG_2hB CENATAC protein_coding retained_intron 11.38946 12.01934 7.376644 1.145919 0.1961736 -0.7035665 3.1801942 3.0541635 1.7392960 0.35274547 0.02800321 -0.80871881 0.24665000 0.25313333 0.23590000 -0.01723333 0.79420906 0.01023277 FALSE FALSE
ENST00000534656 ENSG00000186166 HEK293_OSMI2_2hA HEK293_TMG_2hB CENATAC protein_coding retained_intron 11.38946 12.01934 7.376644 1.145919 0.1961736 -0.7035665 0.7260175 0.4925684 0.7711621 0.15716690 0.23534248 0.63630216 0.06682500 0.04400000 0.10300000 0.05900000 0.29853157 0.01023277 FALSE TRUE
ENST00000583842 ENSG00000186166 HEK293_OSMI2_2hA HEK293_TMG_2hB CENATAC protein_coding retained_intron 11.38946 12.01934 7.376644 1.145919 0.1961736 -0.7035665 0.7589236 0.7034801 0.1277327 0.07413078 0.07387718 -2.37300222 0.05834167 0.05893333 0.01700000 -0.04193333 0.11924670 0.01023277 FALSE TRUE
MSTRG.6416.13 ENSG00000186166 HEK293_OSMI2_2hA HEK293_TMG_2hB CENATAC protein_coding   11.38946 12.01934 7.376644 1.145919 0.1961736 -0.7035665 0.8281559 1.1196506 0.0000000 0.56410582 0.00000000 -6.81973287 0.04990833 0.09313333 0.00000000 -0.09313333 0.18691450 0.01023277 FALSE TRUE
MSTRG.6416.9 ENSG00000186166 HEK293_OSMI2_2hA HEK293_TMG_2hB CENATAC protein_coding   11.38946 12.01934 7.376644 1.145919 0.1961736 -0.7035665 0.6022360 1.2575126 0.2571878 0.48497182 0.25718779 -2.24607412 0.04465000 0.10076667 0.03343333 -0.06733333 0.27891665 0.01023277 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186166 E001 1.1802048 0.0107210759 7.786272e-01 8.575632e-01 11 118998105 118998137 33 + 0.282 0.334 0.335
ENSG00000186166 E002 1.3243333 0.0100755973 3.466989e-01 4.908254e-01 11 118998138 118998144 7 + 0.452 0.284 -0.986
ENSG00000186166 E003 3.3861688 0.0089113833 1.457382e-01 2.558535e-01 11 118998145 118998154 10 + 0.747 0.521 -0.984
ENSG00000186166 E004 4.7523313 0.0040899545 3.176473e-01 4.605387e-01 11 118998155 118998167 13 + 0.813 0.672 -0.571
ENSG00000186166 E005 5.3896130 0.0052142515 2.439722e-01 3.788664e-01 11 118998168 118998174 7 + 0.870 0.713 -0.623
ENSG00000186166 E006 18.1047590 0.0010612223 8.459080e-04 3.422930e-03 11 118998175 118998317 143 + 1.411 1.144 -0.934
ENSG00000186166 E007 1.9960427 0.0761073698 7.015463e-01 8.006781e-01 11 118998318 118998429 112 + 0.376 0.458 0.445
ENSG00000186166 E008 31.0442697 0.0007246653 1.187907e-05 7.758044e-05 11 118998430 118998593 164 + 1.640 1.370 -0.926
ENSG00000186166 E009 20.6175907 0.0009845728 3.108988e-04 1.423881e-03 11 118999011 118999040 30 + 1.468 1.198 -0.941
ENSG00000186166 E010 29.5767540 0.0007168422 9.562609e-06 6.385195e-05 11 118999041 118999109 69 + 1.626 1.348 -0.956
ENSG00000186166 E011 5.5898556 0.0042986096 2.370320e-02 5.920239e-02 11 118999110 118999291 182 + 0.966 0.672 -1.156
ENSG00000186166 E012 4.4360790 0.0674843490 7.955837e-02 1.588426e-01 11 119001613 119001739 127 + 0.897 0.579 -1.303
ENSG00000186166 E013 7.0305084 0.0038554045 1.236343e-02 3.440741e-02 11 119001740 119001825 86 + 1.062 0.767 -1.120
ENSG00000186166 E014 41.1490444 0.0006814808 1.733796e-01 2.925882e-01 11 119009534 119010130 597 + 1.644 1.569 -0.258
ENSG00000186166 E015 42.4213310 0.0006312030 9.392431e-01 9.658359e-01 11 119010131 119010527 397 + 1.596 1.600 0.013
ENSG00000186166 E016 25.8243803 0.0008045764 9.904690e-04 3.925880e-03 11 119010528 119010628 101 + 1.195 1.451 0.896
ENSG00000186166 E017 25.5286491 0.0008000815 1.394185e-04 7.010406e-04 11 119010629 119010763 135 + 1.155 1.458 1.061
ENSG00000186166 E018 44.9707614 0.0009419598 5.822026e-01 7.066093e-01 11 119010764 119010830 67 + 1.653 1.624 -0.099
ENSG00000186166 E019 3.6791416 0.4474056019 4.041480e-01 5.478639e-01 11 119011207 119011220 14 + 0.517 0.691 0.773
ENSG00000186166 E020 46.2296827 0.0010066739 1.565157e-01 2.704727e-01 11 119011221 119011283 63 + 1.586 1.665 0.268
ENSG00000186166 E021 18.7632770 0.0189775593 1.130329e-01 2.099675e-01 11 119011284 119011311 28 + 1.126 1.300 0.618
ENSG00000186166 E022 36.3126635 0.0006176487 3.068129e-01 4.489996e-01 11 119011939 119011958 20 + 1.495 1.558 0.215
ENSG00000186166 E023 46.5647132 0.0004869430 8.704655e-02 1.706636e-01 11 119011959 119012003 45 + 1.576 1.670 0.319
ENSG00000186166 E024 5.3185227 0.0038236013 5.566874e-01 6.852770e-01 11 119012004 119012114 111 + 0.813 0.732 -0.323
ENSG00000186166 E025 10.4038652 0.0104474677 6.615935e-02 1.369772e-01 11 119012115 119012148 34 + 0.842 1.067 0.841
ENSG00000186166 E026 54.4977271 0.0004934378 4.372224e-01 5.792219e-01 11 119012149 119012254 106 + 1.683 1.722 0.133
ENSG00000186166 E027 21.6369627 0.0122078951 5.335266e-01 6.657146e-01 11 119012255 119013231 977 + 1.362 1.299 -0.220
ENSG00000186166 E028 36.8515140 0.0012290934 4.953179e-01 6.321340e-01 11 119013232 119013262 31 + 1.519 1.562 0.147
ENSG00000186166 E029 6.1809625 0.0035189960 5.952009e-01 7.173240e-01 11 119014066 119014213 148 + 0.870 0.800 -0.271
ENSG00000186166 E030 10.4902275 0.0238272617 6.050009e-01 7.254357e-01 11 119014214 119014993 780 + 1.079 1.008 -0.259
ENSG00000186166 E031 53.9736254 0.0004933395 1.313461e-01 2.360268e-01 11 119014994 119015083 90 + 1.653 1.730 0.260
ENSG00000186166 E032 0.1451727 0.0436335166 2.540531e-01   11 119015084 119015092 9 + 0.164 0.000 -9.409
ENSG00000186166 E033 0.4407149 0.0211728293 2.477415e-01 3.832746e-01 11 119015288 119015306 19 + 0.282 0.090 -1.989
ENSG00000186166 E034 61.5028634 0.0004476704 3.615917e-02 8.389565e-02 11 119015307 119015439 133 + 1.687 1.787 0.340
ENSG00000186166 E035 43.5737659 0.0005500529 1.102669e-02 3.122485e-02 11 119015538 119015793 256 + 1.507 1.654 0.502