ENSG00000186162

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000424471 ENSG00000186162 HEK293_OSMI2_2hA HEK293_TMG_2hB CIDECP1 transcribed_unprocessed_pseudogene processed_transcript 13.96231 22.26054 8.53839 0.3917888 0.2118281 -1.381412 1.8668987 2.8281541 1.0334459 0.44659577 0.52080422 -1.4435971 0.13305417 0.12643333 0.11830000 -0.008133333 8.699884e-01 6.562369e-05   FALSE
ENST00000424691 ENSG00000186162 HEK293_OSMI2_2hA HEK293_TMG_2hB CIDECP1 transcribed_unprocessed_pseudogene processed_transcript 13.96231 22.26054 8.53839 0.3917888 0.2118281 -1.381412 7.5559833 14.4343239 4.0308348 1.11191790 0.88853168 -1.8377774 0.51813750 0.64936667 0.47373333 -0.175633333 4.290525e-01 6.562369e-05   FALSE
ENST00000432401 ENSG00000186162 HEK293_OSMI2_2hA HEK293_TMG_2hB CIDECP1 transcribed_unprocessed_pseudogene processed_transcript 13.96231 22.26054 8.53839 0.3917888 0.2118281 -1.381412 0.6969227 0.7016089 0.9865472 0.34903852 0.13327240 0.4858536 0.05630417 0.03180000 0.11590000 0.084100000 8.567942e-02 6.562369e-05 FALSE TRUE
ENST00000433871 ENSG00000186162 HEK293_OSMI2_2hA HEK293_TMG_2hB CIDECP1 transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 13.96231 22.26054 8.53839 0.3917888 0.2118281 -1.381412 1.6691520 2.0855336 0.7049143 1.05077454 0.70491433 -1.5514754 0.11855833 0.09340000 0.08150000 -0.011900000 6.250481e-01 6.562369e-05 FALSE FALSE
ENST00000445082 ENSG00000186162 HEK293_OSMI2_2hA HEK293_TMG_2hB CIDECP1 transcribed_unprocessed_pseudogene processed_transcript 13.96231 22.26054 8.53839 0.3917888 0.2118281 -1.381412 0.8690862 0.5624407 0.6681268 0.03135874 0.07745467 0.2444286 0.07236250 0.02526667 0.07793333 0.052666667 6.562369e-05 6.562369e-05   FALSE
ENST00000686656 ENSG00000186162 HEK293_OSMI2_2hA HEK293_TMG_2hB CIDECP1 transcribed_unprocessed_pseudogene processed_transcript 13.96231 22.26054 8.53839 0.3917888 0.2118281 -1.381412 0.8370681 1.1539155 0.7446777 0.17926726 0.35671727 -0.6250538 0.05980000 0.05156667 0.08943333 0.037866667 7.632294e-01 6.562369e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186162 E001 0.0000000       3 10014237 10014237 1 -      
ENSG00000186162 E002 44.0313748 0.0047793712 2.046736e-12 4.774634e-11 3 10014238 10015526 1289 - 1.862 1.441 -1.429
ENSG00000186162 E003 0.4772466 0.0220708681 7.628153e-01 8.463318e-01 3 10017485 10017488 4 - 0.192 0.140 -0.548
ENSG00000186162 E004 0.4772466 0.0220708681 7.628153e-01 8.463318e-01 3 10017489 10017489 1 - 0.192 0.140 -0.548
ENSG00000186162 E005 242.2098607 0.0002761333 1.074344e-08 1.317099e-07 3 10017490 10018071 582 - 2.207 2.328 0.405
ENSG00000186162 E006 11.3843824 0.0016306650 5.785333e-06 4.059912e-05 3 10022927 10023529 603 - 1.323 0.874 -1.628
ENSG00000186162 E007 14.7830854 0.0606021844 9.723078e-01 9.867248e-01 3 10023530 10023559 30 - 1.138 1.120 -0.067
ENSG00000186162 E008 145.3318973 0.0002973012 1.282367e-01 2.316875e-01 3 10023560 10023747 188 - 2.050 2.090 0.133
ENSG00000186162 E009 144.7147462 0.0008427649 2.840356e-01 4.242462e-01 3 10026041 10026395 355 - 2.110 2.070 -0.136