ENSG00000186153

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355860 ENSG00000186153 HEK293_OSMI2_2hA HEK293_TMG_2hB WWOX protein_coding protein_coding 24.77656 37.65064 21.98696 2.148835 1.256034 -0.7757536 6.186170 7.481740 7.759761 0.49056103 1.2258038 0.05256938 0.2521500 0.1987000 0.35086667 0.1521667 8.901036e-03 8.382852e-10 FALSE TRUE
ENST00000565562 ENSG00000186153 HEK293_OSMI2_2hA HEK293_TMG_2hB WWOX protein_coding processed_transcript 24.77656 37.65064 21.98696 2.148835 1.256034 -0.7757536 5.969920 11.148791 4.294185 1.06774283 0.6582657 -1.37436895 0.2353792 0.2949000 0.19373333 -0.1011667 3.855765e-02 8.382852e-10 FALSE TRUE
ENST00000566780 ENSG00000186153 HEK293_OSMI2_2hA HEK293_TMG_2hB WWOX protein_coding protein_coding 24.77656 37.65064 21.98696 2.148835 1.256034 -0.7757536 6.903619 9.240195 6.974176 0.67795280 0.5653373 -0.40539390 0.2904875 0.2449667 0.32126667 0.0763000 3.479069e-01 8.382852e-10 FALSE TRUE
ENST00000569818 ENSG00000186153 HEK293_OSMI2_2hA HEK293_TMG_2hB WWOX protein_coding protein_coding 24.77656 37.65064 21.98696 2.148835 1.256034 -0.7757536 3.563644 7.533297 1.177034 0.06425652 0.2255744 -2.66783406 0.1300083 0.2013333 0.05283333 -0.1485000 8.382852e-10 8.382852e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186153 E001 2.2121007 0.0093558670 2.050562e-03 7.382995e-03 16 78099400 78099449 50 + 0.000 0.598 12.644
ENSG00000186153 E002 2.6549911 0.0801053898 2.082116e-03 7.479012e-03 16 78099450 78099451 2 + 0.000 0.653 14.699
ENSG00000186153 E003 13.7367816 0.0150074566 7.770097e-07 6.608698e-06 16 78099452 78099625 174 + 0.603 1.263 2.528
ENSG00000186153 E004 11.2594440 0.0474215135 2.535360e-03 8.869452e-03 16 78099626 78099653 28 + 0.687 1.166 1.821
ENSG00000186153 E005 10.5294173 0.0359780931 1.218043e-03 4.701410e-03 16 78099654 78099655 2 + 0.647 1.142 1.906
ENSG00000186153 E006 25.7759187 0.0071542255 1.263591e-04 6.428647e-04 16 78099656 78099674 19 + 1.142 1.482 1.189
ENSG00000186153 E007 32.0976989 0.0076432261 7.435756e-04 3.055982e-03 16 78099675 78099678 4 + 1.289 1.563 0.944
ENSG00000186153 E008 50.7199909 0.0042426377 3.131880e-04 1.433430e-03 16 78099679 78099693 15 + 1.521 1.749 0.775
ENSG00000186153 E009 100.9113466 0.0003453961 6.420982e-01 7.549678e-01 16 78099694 78099733 40 + 1.968 1.988 0.069
ENSG00000186153 E010 95.8786037 0.0003574901 8.394226e-01 8.996521e-01 16 78099734 78099734 1 + 1.962 1.958 -0.014
ENSG00000186153 E011 148.6301686 0.0039735137 6.434448e-01 7.560010e-01 16 78099735 78099785 51 + 2.134 2.152 0.060
ENSG00000186153 E012 210.0212943 0.0015362883 6.426583e-01 7.554022e-01 16 78099786 78099885 100 + 2.287 2.303 0.053
ENSG00000186153 E013 30.7185748 0.0006710604 2.827871e-13 7.541267e-12 16 78099886 78099999 114 + 1.001 1.596 2.092
ENSG00000186153 E014 17.7002748 0.0010807487 4.767684e-11 8.886496e-10 16 78100000 78100199 200 + 0.647 1.379 2.739
ENSG00000186153 E015 157.2014095 0.0002421202 4.202145e-02 9.475834e-02 16 78108423 78108487 65 + 2.210 2.155 -0.182
ENSG00000186153 E016 135.5455623 0.0003362656 3.041770e-01 4.461898e-01 16 78109778 78109835 58 + 2.130 2.102 -0.095
ENSG00000186153 E017 33.3436843 0.0010099147 9.608090e-05 5.036451e-04 16 78111820 78111992 173 + 1.317 1.587 0.931
ENSG00000186153 E018 138.4837965 0.0003079452 6.235119e-05 3.430345e-04 16 78114976 78115154 179 + 2.197 2.080 -0.391
ENSG00000186153 E019 5.1661773 0.0034027165 1.428849e-11 2.900678e-10 16 78115155 78117213 2059 + 1.169 0.240 -4.216
ENSG00000186153 E020 2.9623873 0.0051560317 5.813820e-10 9.010970e-09 16 78117214 78117414 201 + 0.982 0.000 -17.451
ENSG00000186153 E021 7.7032743 0.0042432495 6.945643e-14 2.017819e-12 16 78117415 78118954 1540 + 1.308 0.394 -3.707
ENSG00000186153 E022 23.0179746 0.0022212755 5.111923e-25 5.597910e-23 16 78118955 78120570 1616 + 1.717 0.937 -2.742
ENSG00000186153 E023 0.9253484 0.0145339138 8.882668e-01 9.325749e-01 16 78130049 78130145 97 + 0.269 0.298 0.196
ENSG00000186153 E024 0.0000000       16 78145917 78145933 17 +      
ENSG00000186153 E025 85.6341613 0.0017500454 9.355494e-01 9.634280e-01 16 78164183 78164289 107 + 1.912 1.911 -0.004
ENSG00000186153 E026 0.4418608 0.0252582230 2.809313e-02 6.819566e-02 16 78179708 78179786 79 + 0.359 0.000 -14.767
ENSG00000186153 E027 0.0000000       16 78264469 78264870 402 +      
ENSG00000186153 E028 0.5169874 0.0217681645 9.330836e-01 9.618254e-01 16 78265954 78266059 106 + 0.155 0.174 0.200
ENSG00000186153 E029 0.3697384 0.0248376532 3.980107e-01 5.417467e-01 16 78267071 78267131 61 + 0.000 0.174 12.323
ENSG00000186153 E030 0.2214452 0.0406671738 7.994400e-01   16 78269110 78269158 49 + 0.000 0.096 11.255
ENSG00000186153 E031 0.0000000       16 78270198 78270586 389 +      
ENSG00000186153 E032 16.0543202 0.0012038964 9.729076e-01 9.870902e-01 16 78278603 78278712 110 + 1.205 1.212 0.024
ENSG00000186153 E033 0.5997190 0.1861125208 1.962112e-02 5.067568e-02 16 78280841 78281049 209 + 0.435 0.000 -14.334
ENSG00000186153 E034 2.8785429 0.0052613394 9.323422e-01 9.613690e-01 16 78303338 78307248 3911 + 0.553 0.570 0.074
ENSG00000186153 E035 43.5021802 0.0020943931 2.145221e-01 3.438870e-01 16 78386860 78386948 89 + 1.668 1.599 -0.234
ENSG00000186153 E036 1.2438049 0.0955335509 2.302466e-01 3.627555e-01 16 78386949 78388566 1618 + 0.155 0.396 1.792
ENSG00000186153 E037 30.4454518 0.0006751093 1.648808e-01 2.815439e-01 16 78424870 78424870 1 + 1.527 1.441 -0.293
ENSG00000186153 E038 88.0938207 0.0003645151 2.090921e-01 3.374439e-01 16 78424871 78425055 185 + 1.954 1.909 -0.150
ENSG00000186153 E039 108.7027745 0.0044504424 1.979701e-01 3.236831e-01 16 78432488 78432752 265 + 2.050 1.994 -0.188
ENSG00000186153 E040 0.9921577 0.0126200554 8.815761e-01 9.281129e-01 16 78535747 78535842 96 + 0.269 0.298 0.199
ENSG00000186153 E041 1.1028750 0.0127500892 2.690754e-01 4.075518e-01 16 78574059 78574858 800 + 0.434 0.240 -1.216
ENSG00000186153 E042 0.5869318 0.2823048433 6.215458e-01 7.385038e-01 16 78635847 78636201 355 + 0.269 0.170 -0.836
ENSG00000186153 E043 0.0000000       16 78691242 78691292 51 +      
ENSG00000186153 E044 2.8302812 0.0056483410 2.654147e-01 4.034730e-01 16 78756940 78757015 76 + 0.434 0.624 0.899
ENSG00000186153 E045 0.0000000       16 78780415 78780449 35 +      
ENSG00000186153 E046 0.0000000       16 79040104 79040245 142 +      
ENSG00000186153 E047 0.2955422 0.0286359744 6.799844e-01   16 79196359 79196481 123 + 0.155 0.096 -0.803
ENSG00000186153 E048 271.6811812 0.0127893786 6.530774e-01 7.636593e-01 16 79211608 79212667 1060 + 2.391 2.414 0.078