ENSG00000186111

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335312 ENSG00000186111 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP5K1C protein_coding protein_coding 14.25182 18.65129 11.50644 1.60563 0.6331964 -0.696354 12.018155 17.1866991 8.969188 1.3664137 0.33795993 -0.9374748 0.8275667 0.92263333 0.7810333 -0.14160000 5.608382e-08 5.608382e-08 FALSE TRUE
MSTRG.16169.5 ENSG00000186111 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP5K1C protein_coding   14.25182 18.65129 11.50644 1.60563 0.6331964 -0.696354 1.464495 0.9766157 1.424727 0.2829394 0.06993803 0.5402163 0.1140708 0.05046667 0.1240000 0.07353333 1.924932e-02 5.608382e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186111 E001 608.2351165 0.0074202471 1.773419e-06 1.395162e-05 19 3630183 3631109 927 - 2.594 2.819 0.749
ENSG00000186111 E002 108.9556057 0.0023699527 5.711148e-05 3.171229e-04 19 3631110 3631135 26 - 1.860 2.071 0.709
ENSG00000186111 E003 512.4562413 0.0022878569 8.018181e-09 1.006174e-07 19 3631136 3631967 832 - 2.545 2.734 0.630
ENSG00000186111 E004 455.3537847 0.0001288219 3.285226e-02 7.751410e-02 19 3631968 3632875 908 - 2.579 2.650 0.235
ENSG00000186111 E005 115.9855241 0.0003245847 4.739427e-02 1.045348e-01 19 3632876 3633169 294 - 2.058 2.023 -0.117
ENSG00000186111 E006 17.1572434 0.0075339557 9.329134e-02 1.802691e-01 19 3633437 3633520 84 - 1.301 1.180 -0.428
ENSG00000186111 E007 20.9259380 0.0090577413 3.073715e-05 1.824324e-04 19 3636601 3637535 935 - 1.503 1.178 -1.134
ENSG00000186111 E008 2.8742779 0.0084264686 4.426677e-01 5.842499e-01 19 3637536 3637613 78 - 0.641 0.544 -0.433
ENSG00000186111 E009 3.8804308 0.0611324102 1.534005e-02 4.125968e-02 19 3637614 3638006 393 - 0.866 0.484 -1.630
ENSG00000186111 E010 55.8788475 0.0004467184 6.654698e-02 1.376354e-01 19 3638884 3639016 133 - 1.757 1.701 -0.192
ENSG00000186111 E011 72.8574115 0.0004008849 8.552676e-01 9.105197e-01 19 3641705 3641809 105 - 1.820 1.845 0.085
ENSG00000186111 E012 44.0562211 0.0025175160 6.497130e-01 7.608809e-01 19 3642907 3642939 33 - 1.619 1.625 0.023
ENSG00000186111 E013 46.0463521 0.0005823293 3.926035e-01 5.365533e-01 19 3643243 3643248 6 - 1.648 1.635 -0.046
ENSG00000186111 E014 104.8652660 0.0002841467 2.004797e-01 3.268020e-01 19 3643249 3643381 133 - 2.001 1.988 -0.043
ENSG00000186111 E015 43.9412140 0.0005170694 2.265841e-01 3.583321e-01 19 3644087 3644088 2 - 1.640 1.606 -0.115
ENSG00000186111 E016 105.9422159 0.0002725265 2.369485e-01 3.706419e-01 19 3644089 3644251 163 - 2.003 1.994 -0.031
ENSG00000186111 E017 77.2670806 0.0048112467 5.705808e-01 6.970261e-01 19 3645974 3646058 85 - 1.862 1.867 0.018
ENSG00000186111 E018 53.7428506 0.0066301960 2.071264e-01 3.350822e-01 19 3647338 3647386 49 - 1.741 1.698 -0.146
ENSG00000186111 E019 51.0844404 0.0079966218 1.591386e-01 2.739611e-01 19 3648625 3648708 84 - 1.721 1.666 -0.185
ENSG00000186111 E020 0.0000000       19 3649355 3649429 75 -      
ENSG00000186111 E021 0.0000000       19 3649891 3650023 133 -      
ENSG00000186111 E022 81.6640732 0.0003618162 7.698164e-01 8.513784e-01 19 3651826 3652031 206 - 1.870 1.891 0.071
ENSG00000186111 E023 145.1091003 0.0003057433 7.072136e-06 4.864923e-05 19 3653290 3653589 300 - 2.198 2.095 -0.344
ENSG00000186111 E024 101.7215035 0.0003021349 3.248198e-08 3.632808e-07 19 3656405 3656557 153 - 2.083 1.919 -0.548
ENSG00000186111 E025 101.8562840 0.0026486329 6.319726e-05 3.471104e-04 19 3660966 3661083 118 - 2.067 1.932 -0.454
ENSG00000186111 E026 0.5244761 0.2892627869 3.591164e-01 5.034524e-01 19 3661373 3661526 154 - 0.267 0.099 -1.728
ENSG00000186111 E027 71.9265591 0.0037257110 1.203546e-05 7.848548e-05 19 3661871 3661929 59 - 1.947 1.761 -0.624
ENSG00000186111 E028 69.1066271 0.0028708060 5.238066e-08 5.624211e-07 19 3661930 3662001 72 - 1.955 1.723 -0.780
ENSG00000186111 E029 56.1590637 0.0057030281 6.641428e-04 2.767461e-03 19 3664822 3664856 35 - 1.828 1.663 -0.558
ENSG00000186111 E030 59.8364404 0.0072912225 1.815067e-04 8.844563e-04 19 3664857 3664914 58 - 1.870 1.680 -0.641
ENSG00000186111 E031 42.5773575 0.0193358941 1.110259e-02 3.141301e-02 19 3667322 3667353 32 - 1.717 1.544 -0.590
ENSG00000186111 E032 0.5181333 0.0204784900 2.784181e-01 4.181039e-01 19 3668404 3668440 37 - 0.266 0.097 -1.751
ENSG00000186111 E033 0.3729606 0.0294107008 6.626327e-01 7.709073e-01 19 3669673 3669904 232 - 0.153 0.097 -0.750
ENSG00000186111 E034 46.4414647 0.0352448169 1.611443e-03 5.997703e-03 19 3700297 3700488 192 - 1.809 1.537 -0.922