ENSG00000186063

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340020 ENSG00000186063 HEK293_OSMI2_2hA HEK293_TMG_2hB AIDA protein_coding protein_coding 22.35711 13.1095 33.70659 1.026192 1.356352 1.361745 20.691311 13.00986 31.171954 0.9652862 1.3318660 1.259997 0.94764167 0.993 0.92480000 -0.06820000 2.755551e-05 1.822988e-10 FALSE  
ENST00000495670 ENSG00000186063 HEK293_OSMI2_2hA HEK293_TMG_2hB AIDA protein_coding processed_transcript 22.35711 13.1095 33.70659 1.026192 1.356352 1.361745 1.092924 0.00000 2.227794 0.0000000 0.4680242 7.805933 0.03184167 0.000 0.06606667 0.06606667 1.822988e-10 1.822988e-10    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186063 E001 5.0338038 0.0097168917 1.538457e-02 4.136359e-02 1 222666388 222666445 58 - 0.841 0.424 -1.840
ENSG00000186063 E002 27.0221116 0.0007746247 3.285856e-08 3.671457e-07 1 222668013 222668612 600 - 1.270 1.639 1.274
ENSG00000186063 E003 162.8858647 0.0002280528 3.361390e-11 6.419407e-10 1 222668613 222669398 786 - 2.113 2.299 0.620
ENSG00000186063 E004 27.3123326 0.0111416568 9.563275e-01 9.766390e-01 1 222669399 222669413 15 - 1.420 1.419 -0.004
ENSG00000186063 E005 130.2142888 0.0019503731 5.829815e-02 1.237067e-01 1 222669414 222669606 193 - 2.058 2.127 0.234
ENSG00000186063 E006 69.7735842 0.0004193233 2.599523e-03 9.062953e-03 1 222669607 222669688 82 - 1.765 1.898 0.447
ENSG00000186063 E007 196.4585890 0.0002865682 6.382702e-01 7.519331e-01 1 222669689 222669989 301 - 2.252 2.263 0.036
ENSG00000186063 E008 108.1257322 0.0003556459 2.388561e-02 5.957000e-02 1 222670133 222670189 57 - 2.022 1.933 -0.298
ENSG00000186063 E009 90.9638316 0.0003474276 7.665791e-02 1.541417e-01 1 222670190 222670244 55 - 1.945 1.869 -0.254
ENSG00000186063 E010 63.6415325 0.0004640663 7.481820e-02 1.512370e-01 1 222670245 222670250 6 - 1.797 1.706 -0.308
ENSG00000186063 E011 63.3061597 0.0004312669 1.671148e-01 2.844460e-01 1 222673313 222673373 61 - 1.790 1.720 -0.238
ENSG00000186063 E012 81.5464127 0.0008565515 3.018221e-01 4.436493e-01 1 222673374 222673435 62 - 1.894 1.846 -0.162
ENSG00000186063 E013 125.7745307 0.0008265072 1.088369e-01 2.038258e-01 1 222676096 222676218 123 - 2.082 2.021 -0.205
ENSG00000186063 E014 108.2188005 0.0021457721 3.920938e-01 5.360347e-01 1 222686930 222687033 104 - 2.013 1.974 -0.129
ENSG00000186063 E015 66.7452934 0.0004221435 7.814991e-01 8.596068e-01 1 222687034 222687036 3 - 1.791 1.803 0.038
ENSG00000186063 E016 90.0322179 0.0003152206 5.653049e-01 6.924207e-01 1 222687595 222687658 64 - 1.917 1.938 0.072
ENSG00000186063 E017 77.9186451 0.0063748569 8.498250e-01 9.068096e-01 1 222693789 222693843 55 - 1.863 1.849 -0.050
ENSG00000186063 E018 80.4316376 0.0106229417 3.905166e-02 8.929146e-02 1 222694210 222694263 54 - 1.910 1.769 -0.473
ENSG00000186063 E019 75.4418043 0.0004416349 4.590684e-03 1.479319e-02 1 222703148 222703217 70 - 1.881 1.746 -0.454
ENSG00000186063 E020 1.2629112 0.0118908373 3.680538e-01 5.124550e-01 1 222711379 222711545 167 - 0.369 0.191 -1.275
ENSG00000186063 E021 1.6282840 0.1687652592 6.165441e-01 7.345880e-01 1 222711546 222712207 662 - 0.435 0.319 -0.665
ENSG00000186063 E022 51.6277711 0.0007396667 9.862094e-03 2.842496e-02 1 222712208 222712737 530 - 1.723 1.574 -0.507
ENSG00000186063 E023 0.5890081 0.0235679228 3.071263e-01 4.493013e-01 1 222713029 222713210 182 - 0.141 0.323 1.528