ENSG00000186020

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334116 ENSG00000186020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF529 protein_coding protein_coding 6.972943 2.794939 10.40145 0.168614 0.3334803 1.89213 0.4431214 0.472379640 0.5621265 0.312311940 0.41703391 0.24616527 0.08251250 0.177066667 0.05246667 -0.124600000 7.800084e-01 4.574475e-05 FALSE TRUE
ENST00000586458 ENSG00000186020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF529 protein_coding processed_transcript 6.972943 2.794939 10.40145 0.168614 0.3334803 1.89213 0.8708814 0.761756306 0.7359219 0.158557599 0.09194444 -0.04912079 0.17385833 0.268600000 0.07123333 -0.197366667 4.574475e-05 4.574475e-05   FALSE
ENST00000587286 ENSG00000186020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF529 protein_coding processed_transcript 6.972943 2.794939 10.40145 0.168614 0.3334803 1.89213 0.2873260 0.289463023 0.5619441 0.189104878 0.18353785 0.93349625 0.04873750 0.108366667 0.05310000 -0.055266667 9.258250e-01 4.574475e-05   FALSE
ENST00000591340 ENSG00000186020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF529 protein_coding protein_coding 6.972943 2.794939 10.40145 0.168614 0.3334803 1.89213 2.0956696 0.816353222 2.9557355 0.422994603 0.42626580 1.84355945 0.31876250 0.283833333 0.28646667 0.002633333 9.216938e-01 4.574475e-05 FALSE TRUE
MSTRG.17032.15 ENSG00000186020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF529 protein_coding   6.972943 2.794939 10.40145 0.168614 0.3334803 1.89213 0.8410319 0.120091934 1.4746727 0.120091934 0.09939807 3.51254150 0.09412083 0.044100000 0.14203333 0.097933333 2.058917e-01 4.574475e-05   FALSE
MSTRG.17032.3 ENSG00000186020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF529 protein_coding   6.972943 2.794939 10.40145 0.168614 0.3334803 1.89213 0.2692887 0.015000174 0.7894146 0.015000174 0.41732804 4.99893393 0.02565000 0.004800000 0.07410000 0.069300000 5.522808e-01 4.574475e-05 FALSE TRUE
MSTRG.17032.8 ENSG00000186020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF529 protein_coding   6.972943 2.794939 10.40145 0.168614 0.3334803 1.89213 0.9285752 0.000000000 1.4370367 0.000000000 0.71857308 7.17695774 0.08925417 0.000000000 0.13903333 0.139033333 3.390714e-01 4.574475e-05 FALSE TRUE
MSTRG.17032.9 ENSG00000186020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF529 protein_coding   6.972943 2.794939 10.40145 0.168614 0.3334803 1.89213 0.5859884 0.007238136 0.9686654 0.007238136 0.18557972 5.82713994 0.06357500 0.002333333 0.09446667 0.092133333 2.877602e-04 4.574475e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186020 E001 0.1515154 0.0435371291 1.000000e+00   19 36534774 36534882 109 - 0.069 0.000 -7.220
ENSG00000186020 E002 0.1451727 0.0436657915 1.000000e+00   19 36534883 36534961 79 - 0.069 0.000 -7.920
ENSG00000186020 E003 0.0000000       19 36543613 36543615 3 -      
ENSG00000186020 E004 1.8645150 0.3402615548 1.669711e-01 2.842652e-01 19 36543616 36543828 213 - 0.270 0.709 2.255
ENSG00000186020 E005 137.8370732 0.0044852850 2.039024e-22 1.702454e-20 19 36543829 36545869 2041 - 1.932 2.357 1.424
ENSG00000186020 E006 13.6761669 0.0015122250 5.472371e-02 1.175145e-01 19 36545870 36545933 64 - 1.038 1.277 0.855
ENSG00000186020 E007 36.1583309 0.0009147588 1.751739e-02 4.607782e-02 19 36545934 36546636 703 - 1.448 1.653 0.701
ENSG00000186020 E008 12.9586004 0.0160277852 2.093502e-01 3.377656e-01 19 36546637 36546724 88 - 1.025 1.218 0.696
ENSG00000186020 E009 20.2909518 0.0128019700 4.983782e-01 6.348420e-01 19 36546725 36546824 100 - 1.266 1.251 -0.053
ENSG00000186020 E010 66.4019811 0.0158765515 7.204123e-03 2.175603e-02 19 36546825 36547389 565 - 1.797 1.647 -0.509
ENSG00000186020 E011 40.1073127 0.0007649427 9.269556e-04 3.709291e-03 19 36547390 36547557 168 - 1.585 1.421 -0.562
ENSG00000186020 E012 67.0345955 0.0090749036 7.702778e-07 6.557919e-06 19 36547558 36548012 455 - 1.826 1.532 -1.001
ENSG00000186020 E013 29.8051812 0.0021980977 3.193140e-06 2.374512e-05 19 36548013 36548100 88 - 1.490 1.146 -1.203
ENSG00000186020 E014 32.2159077 0.0010972882 9.605341e-07 7.997991e-06 19 36548101 36548226 126 - 1.523 1.183 -1.183
ENSG00000186020 E015 15.5444987 0.0011572248 5.227911e-04 2.244916e-03 19 36548227 36548227 1 - 1.224 0.893 -1.209
ENSG00000186020 E016 25.2102814 0.0011925183 9.471636e-05 4.971802e-04 19 36548228 36548322 95 - 1.415 1.126 -1.013
ENSG00000186020 E017 6.4647890 0.0075466548 5.345738e-02 1.153048e-01 19 36549235 36549357 123 - 0.865 0.613 -1.031
ENSG00000186020 E018 4.4404010 0.0035237220 1.474976e-02 3.992596e-02 19 36551810 36551876 67 - 0.750 0.350 -1.899
ENSG00000186020 E019 9.4707292 0.0878465854 8.581840e-02 1.686991e-01 19 36551877 36551977 101 - 1.017 0.732 -1.095
ENSG00000186020 E020 31.1170902 0.0011220355 1.358254e-10 2.346500e-09 19 36554670 36554796 127 - 1.532 1.012 -1.831
ENSG00000186020 E021 23.1336381 0.0008745601 3.824506e-07 3.461073e-06 19 36556104 36556197 94 - 1.400 0.956 -1.585
ENSG00000186020 E022 13.5593199 0.0027082163 1.121352e-01 2.086661e-01 19 36572333 36572392 60 - 1.130 1.012 -0.428
ENSG00000186020 E023 9.4488940 0.0093634188 1.414781e-01 2.500430e-01 19 36573140 36573292 153 - 0.996 0.856 -0.526
ENSG00000186020 E024 47.2691149 0.0289167509 2.694967e-10 4.416935e-09 19 36580255 36582397 2143 - 1.357 2.005 2.205
ENSG00000186020 E025 7.1158428 0.0024623345 1.996863e-02 5.141827e-02 19 36582398 36582704 307 - 0.750 1.084 1.269
ENSG00000186020 E026 3.1657598 0.0049014666 5.805772e-01 7.052874e-01 19 36587402 36587457 56 - 0.592 0.541 -0.233
ENSG00000186020 E027 17.7427202 0.0012951392 5.151757e-01 6.498681e-01 19 36589615 36589701 87 - 1.219 1.217 -0.010
ENSG00000186020 E028 13.8598452 0.0016365397 5.035108e-01 6.394882e-01 19 36605126 36605283 158 - 1.119 1.106 -0.047