ENSG00000186020

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-8 / 8
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000334116	ENSG00000186020	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ZNF529	protein_coding	protein_coding	6.972943	2.794939	10.40145	0.168614	0.3334803	1.89213	0.4431214	0.472379640	0.5621265	0.312311940	0.41703391	0.24616527	0.08251250	0.177066667	0.05246667	-0.124600000	7.800084e-01	4.574475e-05	FALSE	TRUE
ENST00000586458	ENSG00000186020	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ZNF529	protein_coding	processed_transcript	6.972943	2.794939	10.40145	0.168614	0.3334803	1.89213	0.8708814	0.761756306	0.7359219	0.158557599	0.09194444	-0.04912079	0.17385833	0.268600000	0.07123333	-0.197366667	4.574475e-05	4.574475e-05		FALSE
ENST00000587286	ENSG00000186020	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ZNF529	protein_coding	processed_transcript	6.972943	2.794939	10.40145	0.168614	0.3334803	1.89213	0.2873260	0.289463023	0.5619441	0.189104878	0.18353785	0.93349625	0.04873750	0.108366667	0.05310000	-0.055266667	9.258250e-01	4.574475e-05		FALSE
ENST00000591340	ENSG00000186020	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ZNF529	protein_coding	protein_coding	6.972943	2.794939	10.40145	0.168614	0.3334803	1.89213	2.0956696	0.816353222	2.9557355	0.422994603	0.42626580	1.84355945	0.31876250	0.283833333	0.28646667	0.002633333	9.216938e-01	4.574475e-05	FALSE	TRUE
MSTRG.17032.15	ENSG00000186020	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ZNF529	protein_coding		6.972943	2.794939	10.40145	0.168614	0.3334803	1.89213	0.8410319	0.120091934	1.4746727	0.120091934	0.09939807	3.51254150	0.09412083	0.044100000	0.14203333	0.097933333	2.058917e-01	4.574475e-05		FALSE
MSTRG.17032.3	ENSG00000186020	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ZNF529	protein_coding		6.972943	2.794939	10.40145	0.168614	0.3334803	1.89213	0.2692887	0.015000174	0.7894146	0.015000174	0.41732804	4.99893393	0.02565000	0.004800000	0.07410000	0.069300000	5.522808e-01	4.574475e-05	FALSE	TRUE
MSTRG.17032.8	ENSG00000186020	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ZNF529	protein_coding		6.972943	2.794939	10.40145	0.168614	0.3334803	1.89213	0.9285752	0.000000000	1.4370367	0.000000000	0.71857308	7.17695774	0.08925417	0.000000000	0.13903333	0.139033333	3.390714e-01	4.574475e-05	FALSE	TRUE
MSTRG.17032.9	ENSG00000186020	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ZNF529	protein_coding		6.972943	2.794939	10.40145	0.168614	0.3334803	1.89213	0.5859884	0.007238136	0.9686654	0.007238136	0.18557972	5.82713994	0.06357500	0.002333333	0.09446667	0.092133333	2.877602e-04	4.574475e-05	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 28
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Columns:
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000186020	E001	0.1515154	0.0435371291	1.000000e+00		19	36534774	36534882	109	-	0.069	0.000	-7.220
ENSG00000186020	E002	0.1451727	0.0436657915	1.000000e+00		19	36534883	36534961	79	-	0.069	0.000	-7.920
ENSG00000186020	E003	0.0000000				19	36543613	36543615	3	-
ENSG00000186020	E004	1.8645150	0.3402615548	1.669711e-01	2.842652e-01	19	36543616	36543828	213	-	0.270	0.709	2.255
ENSG00000186020	E005	137.8370732	0.0044852850	2.039024e-22	1.702454e-20	19	36543829	36545869	2041	-	1.932	2.357	1.424
ENSG00000186020	E006	13.6761669	0.0015122250	5.472371e-02	1.175145e-01	19	36545870	36545933	64	-	1.038	1.277	0.855
ENSG00000186020	E007	36.1583309	0.0009147588	1.751739e-02	4.607782e-02	19	36545934	36546636	703	-	1.448	1.653	0.701
ENSG00000186020	E008	12.9586004	0.0160277852	2.093502e-01	3.377656e-01	19	36546637	36546724	88	-	1.025	1.218	0.696
ENSG00000186020	E009	20.2909518	0.0128019700	4.983782e-01	6.348420e-01	19	36546725	36546824	100	-	1.266	1.251	-0.053
ENSG00000186020	E010	66.4019811	0.0158765515	7.204123e-03	2.175603e-02	19	36546825	36547389	565	-	1.797	1.647	-0.509
ENSG00000186020	E011	40.1073127	0.0007649427	9.269556e-04	3.709291e-03	19	36547390	36547557	168	-	1.585	1.421	-0.562
ENSG00000186020	E012	67.0345955	0.0090749036	7.702778e-07	6.557919e-06	19	36547558	36548012	455	-	1.826	1.532	-1.001
ENSG00000186020	E013	29.8051812	0.0021980977	3.193140e-06	2.374512e-05	19	36548013	36548100	88	-	1.490	1.146	-1.203
ENSG00000186020	E014	32.2159077	0.0010972882	9.605341e-07	7.997991e-06	19	36548101	36548226	126	-	1.523	1.183	-1.183
ENSG00000186020	E015	15.5444987	0.0011572248	5.227911e-04	2.244916e-03	19	36548227	36548227	1	-	1.224	0.893	-1.209
ENSG00000186020	E016	25.2102814	0.0011925183	9.471636e-05	4.971802e-04	19	36548228	36548322	95	-	1.415	1.126	-1.013
ENSG00000186020	E017	6.4647890	0.0075466548	5.345738e-02	1.153048e-01	19	36549235	36549357	123	-	0.865	0.613	-1.031
ENSG00000186020	E018	4.4404010	0.0035237220	1.474976e-02	3.992596e-02	19	36551810	36551876	67	-	0.750	0.350	-1.899
ENSG00000186020	E019	9.4707292	0.0878465854	8.581840e-02	1.686991e-01	19	36551877	36551977	101	-	1.017	0.732	-1.095
ENSG00000186020	E020	31.1170902	0.0011220355	1.358254e-10	2.346500e-09	19	36554670	36554796	127	-	1.532	1.012	-1.831
ENSG00000186020	E021	23.1336381	0.0008745601	3.824506e-07	3.461073e-06	19	36556104	36556197	94	-	1.400	0.956	-1.585
ENSG00000186020	E022	13.5593199	0.0027082163	1.121352e-01	2.086661e-01	19	36572333	36572392	60	-	1.130	1.012	-0.428
ENSG00000186020	E023	9.4488940	0.0093634188	1.414781e-01	2.500430e-01	19	36573140	36573292	153	-	0.996	0.856	-0.526
ENSG00000186020	E024	47.2691149	0.0289167509	2.694967e-10	4.416935e-09	19	36580255	36582397	2143	-	1.357	2.005	2.205
ENSG00000186020	E025	7.1158428	0.0024623345	1.996863e-02	5.141827e-02	19	36582398	36582704	307	-	0.750	1.084	1.269
ENSG00000186020	E026	3.1657598	0.0049014666	5.805772e-01	7.052874e-01	19	36587402	36587457	56	-	0.592	0.541	-0.233
ENSG00000186020	E027	17.7427202	0.0012951392	5.151757e-01	6.498681e-01	19	36589615	36589701	87	-	1.219	1.217	-0.010
ENSG00000186020	E028	13.8598452	0.0016365397	5.035108e-01	6.394882e-01	19	36605126	36605283	158	-	1.119	1.106	-0.047

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000186020

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3