ENSG00000186001

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334859 ENSG00000186001 HEK293_OSMI2_2hA HEK293_TMG_2hB LRCH3 protein_coding protein_coding 11.03374 10.25895 11.01854 0.1281211 0.7235759 0.1029536 0.9487150 0.3680069 1.059309 0.2016234 0.21857534 1.5001940 0.08320000 0.03570000 0.09446667 0.05876667 1.642517e-01 1.66357e-08 FALSE TRUE
ENST00000414675 ENSG00000186001 HEK293_OSMI2_2hA HEK293_TMG_2hB LRCH3 protein_coding protein_coding 11.03374 10.25895 11.01854 0.1281211 0.7235759 0.1029536 1.7809991 1.0132719 2.307195 0.3134092 0.36870814 1.1791899 0.15936667 0.09883333 0.21516667 0.11633333 1.961965e-01 1.66357e-08 FALSE TRUE
ENST00000425562 ENSG00000186001 HEK293_OSMI2_2hA HEK293_TMG_2hB LRCH3 protein_coding protein_coding 11.03374 10.25895 11.01854 0.1281211 0.7235759 0.1029536 3.8167421 4.2093716 3.436475 0.1454517 0.07890333 -0.2919065 0.35205417 0.41063333 0.31480000 -0.09583333 1.131483e-01 1.66357e-08 FALSE TRUE
ENST00000476664 ENSG00000186001 HEK293_OSMI2_2hA HEK293_TMG_2hB LRCH3 protein_coding retained_intron 11.03374 10.25895 11.01854 0.1281211 0.7235759 0.1029536 2.3375003 3.1238557 1.446352 0.1685286 0.74206773 -1.1055796 0.21157917 0.30486667 0.12303333 -0.18183333 5.132376e-01 1.66357e-08   FALSE
ENST00000483442 ENSG00000186001 HEK293_OSMI2_2hA HEK293_TMG_2hB LRCH3 protein_coding retained_intron 11.03374 10.25895 11.01854 0.1281211 0.7235759 0.1029536 0.1284318 0.5631426 0.000000 0.5631426 0.00000000 -5.8408222 0.01170417 0.05393333 0.00000000 -0.05393333 8.067225e-01 1.66357e-08   FALSE
MSTRG.24389.8 ENSG00000186001 HEK293_OSMI2_2hA HEK293_TMG_2hB LRCH3 protein_coding   11.03374 10.25895 11.01854 0.1281211 0.7235759 0.1029536 0.6425354 0.0000000 1.323329 0.0000000 0.42903970 7.0588895 0.05576667 0.00000000 0.11986667 0.11986667 1.663570e-08 1.66357e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000186001 E001 0.1817044 0.0394068355 4.818825e-01   3 197791226 197791234 9 + 0.000 0.123 10.064
ENSG00000186001 E002 0.3268771 0.0293498826 1.000000e+00   3 197791235 197791242 8 + 0.122 0.123 0.023
ENSG00000186001 E003 0.8354585 0.5902181198 8.375807e-01 8.984557e-01 3 197791243 197791253 11 + 0.215 0.300 0.632
ENSG00000186001 E004 0.8354585 0.5902181198 8.375807e-01 8.984557e-01 3 197791254 197791258 5 + 0.215 0.300 0.632
ENSG00000186001 E005 1.4244666 0.0624401525 7.650410e-01 8.479105e-01 3 197791259 197791263 5 + 0.360 0.420 0.339
ENSG00000186001 E006 3.5990984 0.0052405175 6.309273e-02 1.318616e-01 3 197791264 197791270 7 + 0.790 0.518 -1.170
ENSG00000186001 E007 6.9894093 0.0057153343 1.973505e-02 5.092803e-02 3 197791271 197791273 3 + 1.029 0.748 -1.076
ENSG00000186001 E008 42.3151883 0.0040912413 7.087378e-04 2.930341e-03 3 197791274 197791540 267 + 1.730 1.526 -0.693
ENSG00000186001 E009 45.7214637 0.0006321360 1.879323e-06 1.470964e-05 3 197814908 197815052 145 + 1.781 1.537 -0.829
ENSG00000186001 E010 57.4835002 0.0004142661 1.352199e-09 1.955795e-08 3 197817176 197817302 127 + 1.893 1.616 -0.936
ENSG00000186001 E011 28.8760011 0.0011355068 3.731634e-04 1.670124e-03 3 197820325 197820332 8 + 1.578 1.349 -0.787
ENSG00000186001 E012 53.9219387 0.0055309420 1.410852e-03 5.342428e-03 3 197820333 197820430 98 + 1.825 1.642 -0.621
ENSG00000186001 E013 0.0000000       3 197822831 197823465 635 +      
ENSG00000186001 E014 67.6250854 0.0040432055 9.697533e-05 5.078839e-04 3 197826878 197827014 137 + 1.929 1.732 -0.665
ENSG00000186001 E015 58.9092582 0.0004050511 4.824822e-03 1.544365e-02 3 197829564 197829673 110 + 1.840 1.717 -0.414
ENSG00000186001 E016 54.2916764 0.0006297634 7.297556e-01 8.218747e-01 3 197830770 197830863 94 + 1.750 1.739 -0.038
ENSG00000186001 E017 53.5571689 0.0007759192 6.473024e-01 7.589962e-01 3 197832197 197832317 121 + 1.747 1.731 -0.057
ENSG00000186001 E018 43.3615281 0.0011267316 7.204037e-02 1.467269e-01 3 197835674 197835738 65 + 1.694 1.602 -0.312
ENSG00000186001 E019 43.1965750 0.0005421346 7.491812e-02 1.513981e-01 3 197835739 197835796 58 + 1.694 1.606 -0.300
ENSG00000186001 E020 37.7385076 0.0005746872 6.703655e-01 7.768266e-01 3 197835797 197835822 26 + 1.599 1.580 -0.065
ENSG00000186001 E021 58.1130431 0.0058256766 3.696678e-01 5.140676e-01 3 197839321 197839397 77 + 1.797 1.750 -0.158
ENSG00000186001 E022 51.5125512 0.0004754594 2.572649e-01 3.943401e-01 3 197847409 197847460 52 + 1.747 1.698 -0.168
ENSG00000186001 E023 0.5181333 0.0209497872 5.738717e-01 6.997784e-01 3 197847845 197847871 27 + 0.216 0.123 -0.976
ENSG00000186001 E024 61.5665628 0.0004319275 8.187837e-02 1.625069e-01 3 197847872 197847958 87 + 1.834 1.761 -0.244
ENSG00000186001 E025 47.4084051 0.0005217146 5.074948e-01 6.429928e-01 3 197847959 197848000 42 + 1.702 1.674 -0.096
ENSG00000186001 E026 30.1798146 0.0015840451 3.786159e-01 5.229259e-01 3 197848001 197848021 21 + 1.459 1.520 0.211
ENSG00000186001 E027 0.1482932 0.0416302396 4.832355e-01   3 197848022 197848499 478 + 0.000 0.123 12.483
ENSG00000186001 E028 0.2966881 0.0270706576 2.036604e-01   3 197852328 197852560 233 + 0.216 0.000 -14.536
ENSG00000186001 E029 39.1120300 0.0006417320 5.129295e-02 1.114573e-01 3 197852561 197852620 60 + 1.539 1.653 0.388
ENSG00000186001 E030 0.0000000       3 197854390 197854391 2 +      
ENSG00000186001 E031 39.2049684 0.0006292036 9.291824e-02 1.796911e-01 3 197854392 197854445 54 + 1.551 1.649 0.335
ENSG00000186001 E032 0.2944980 0.4058279171 3.043467e-01   3 197858818 197858820 3 + 0.216 0.000 -13.196
ENSG00000186001 E033 0.2944980 0.4058279171 3.043467e-01   3 197858821 197858821 1 + 0.216 0.000 -13.196
ENSG00000186001 E034 0.2944980 0.4058279171 3.043467e-01   3 197858822 197858833 12 + 0.216 0.000 -13.196
ENSG00000186001 E035 25.4632370 0.0009324260 3.277906e-01 4.712570e-01 3 197858834 197858905 72 + 1.379 1.451 0.248
ENSG00000186001 E036 0.7728905 0.0143616504 1.719258e-01 2.907077e-01 3 197858906 197859439 534 + 0.360 0.123 -1.977
ENSG00000186001 E037 37.3513248 0.0006838996 1.243960e-01 2.262438e-01 3 197865423 197865471 49 + 1.531 1.623 0.315
ENSG00000186001 E038 48.8417242 0.0004796704 6.203862e-01 7.375654e-01 3 197866112 197866219 108 + 1.680 1.709 0.100
ENSG00000186001 E039 57.9414247 0.0087025463 6.229045e-01 7.396192e-01 3 197870160 197870278 119 + 1.748 1.779 0.107
ENSG00000186001 E040 60.9225321 0.0024377531 6.838949e-01 7.869833e-01 3 197871325 197871422 98 + 1.799 1.783 -0.056
ENSG00000186001 E041 49.9639791 0.0075899988 7.710762e-01 8.522194e-01 3 197871423 197871462 40 + 1.717 1.701 -0.052
ENSG00000186001 E042 3.2171645 0.0050208510 3.822727e-01 5.265025e-01 3 197871463 197871585 123 + 0.688 0.559 -0.563
ENSG00000186001 E043 0.7728905 0.0143616504 1.719258e-01 2.907077e-01 3 197875694 197875697 4 + 0.360 0.123 -1.977
ENSG00000186001 E044 55.4833580 0.0037718673 8.257332e-01 8.902771e-01 3 197875698 197875775 78 + 1.745 1.762 0.058
ENSG00000186001 E045 3.2997692 0.0048844964 5.050871e-02 1.100625e-01 3 197875776 197876340 565 + 0.767 0.472 -1.300
ENSG00000186001 E046 5.0898121 0.0031379881 2.907792e-03 9.992790e-03 3 197880512 197880757 246 + 0.958 0.559 -1.622
ENSG00000186001 E047 29.7261844 0.0007288836 8.692573e-01 9.199899e-01 3 197880758 197883376 2619 + 1.483 1.498 0.053
ENSG00000186001 E048 162.1720801 0.0004327182 9.414629e-08 9.606147e-07 3 197883541 197884199 659 + 2.122 2.277 0.520
ENSG00000186001 E049 231.1923218 0.0012201558 8.415902e-16 3.211213e-14 3 197884200 197885536 1337 + 2.232 2.454 0.741
ENSG00000186001 E050 200.6493866 0.0021752570 4.983850e-04 2.154029e-03 3 197885537 197888436 2900 + 2.239 2.353 0.380
ENSG00000186001 E051 2.8708119 0.0965792176 5.568369e-04 2.373039e-03 3 197899306 197899498 193 + 0.835 0.123 -4.151