ENSG00000185920

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331920 ENSG00000185920 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCH1 protein_coding protein_coding 4.813299 3.48843 4.389762 0.10724 0.369496 0.3307178 0.5900558 0.39662995 0.6430659 0.08450558 0.07396663 0.6835120 0.12744167 0.11243333 0.1515000 0.03906667 6.882655e-01 4.741215e-19 FALSE TRUE
ENST00000429896 ENSG00000185920 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCH1 protein_coding protein_coding 4.813299 3.48843 4.389762 0.10724 0.369496 0.3307178 0.8111022 0.09061957 1.4603352 0.06034316 0.28138688 3.8691622 0.15286250 0.02526667 0.3331333 0.30786667 1.246973e-04 4.741215e-19 FALSE TRUE
ENST00000547672 ENSG00000185920 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCH1 protein_coding protein_coding 4.813299 3.48843 4.389762 0.10724 0.369496 0.3307178 0.2712740 0.24831248 0.0000000 0.12967456 0.00000000 -4.6910454 0.05967083 0.07140000 0.0000000 -0.07140000 9.619476e-02 4.741215e-19 FALSE FALSE
ENST00000692981 ENSG00000185920 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCH1 protein_coding protein_coding 4.813299 3.48843 4.389762 0.10724 0.369496 0.3307178 1.6912191 0.99286576 1.4942618 0.04311850 0.26800217 0.5849272 0.34858750 0.28473333 0.3437667 0.05903333 7.585885e-01 4.741215e-19 FALSE TRUE
ENST00000693534 ENSG00000185920 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCH1 protein_coding processed_transcript 4.813299 3.48843 4.389762 0.10724 0.369496 0.3307178 0.4462024 1.37812210 0.0000000 0.11926559 0.00000000 -7.1169907 0.12462083 0.39746667 0.0000000 -0.39746667 4.741215e-19 4.741215e-19 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185920 E001 2.8420086 0.0056662749 6.409825e-04 2.684000e-03 9 95442980 95443411 432 - 0.239 0.823 2.948
ENSG00000185920 E002 0.9943332 0.0212156811 4.521391e-03 1.460318e-02 9 95443412 95443424 13 - 0.000 0.502 15.122
ENSG00000185920 E003 0.9598778 0.1701187037 1.012597e-01 1.923895e-01 9 95443425 95443430 6 - 0.095 0.443 2.864
ENSG00000185920 E004 81.0308006 0.0208196644 3.941091e-12 8.763238e-11 9 95443431 95444161 731 - 1.565 2.162 2.013
ENSG00000185920 E005 3.2065356 0.0487016902 1.575863e-04 7.809323e-04 9 95444162 95444216 55 - 0.173 0.881 3.760
ENSG00000185920 E006 188.5213677 0.0069954699 2.381419e-06 1.821956e-05 9 95444217 95446065 1849 - 2.149 2.404 0.850
ENSG00000185920 E007 23.9584435 0.0242497225 4.936317e-02 1.080273e-01 9 95446066 95446391 326 - 1.257 1.517 0.900
ENSG00000185920 E008 0.8804848 0.2066405467 9.732613e-01 9.873091e-01 9 95446392 95446910 519 - 0.238 0.277 0.289
ENSG00000185920 E009 55.4489113 0.0004965080 9.693544e-03 2.800613e-02 9 95446911 95447451 541 - 1.657 1.835 0.601
ENSG00000185920 E010 31.8801480 0.0006597086 2.747790e-02 6.696518e-02 9 95449069 95449323 255 - 1.417 1.608 0.653
ENSG00000185920 E011 3.5656857 0.0174366833 8.106817e-01 8.798946e-01 9 95449324 95449840 517 - 0.645 0.651 0.028
ENSG00000185920 E012 22.3060602 0.0008828611 2.969049e-01 4.381929e-01 9 95449841 95449940 100 - 1.302 1.432 0.453
ENSG00000185920 E013 0.4470576 0.0212933542 8.489967e-01 9.062882e-01 9 95449941 95450123 183 - 0.173 0.156 -0.171
ENSG00000185920 E014 0.4762024 0.1850798077 8.906615e-01 9.341783e-01 9 95450124 95450139 16 - 0.173 0.157 -0.165
ENSG00000185920 E015 8.1316160 0.0080511791 4.236124e-02 9.538037e-02 9 95450140 95453477 3338 - 1.022 0.823 -0.753
ENSG00000185920 E016 24.2703966 0.0009208741 8.693684e-01 9.200252e-01 9 95453478 95453620 143 - 1.375 1.418 0.150
ENSG00000185920 E017 24.2438853 0.0117378197 3.694187e-01 5.138344e-01 9 95456276 95456406 131 - 1.401 1.374 -0.092
ENSG00000185920 E018 12.0463024 0.0388911309 1.301097e-01 2.343140e-01 9 95456407 95456413 7 - 1.160 1.008 -0.548
ENSG00000185920 E019 38.2152535 0.0081781529 2.773878e-01 4.169466e-01 9 95458013 95458293 281 - 1.592 1.570 -0.074
ENSG00000185920 E020 31.4736120 0.0072055745 4.802474e-01 6.185510e-01 9 95459600 95459783 184 - 1.501 1.503 0.007
ENSG00000185920 E021 0.0000000       9 95459903 95459955 53 -      
ENSG00000185920 E022 32.2087808 0.0117360477 8.553644e-01 9.105766e-01 9 95461856 95461998 143 - 1.481 1.550 0.239
ENSG00000185920 E023 32.7166017 0.0017392509 4.793219e-01 6.177076e-01 9 95467116 95467286 171 - 1.515 1.526 0.038
ENSG00000185920 E024 22.3054140 0.0109104915 1.005921e-01 1.913571e-01 9 95467287 95467425 139 - 1.396 1.303 -0.324
ENSG00000185920 E025 27.6338426 0.0009533511 3.365199e-01 4.803656e-01 9 95468751 95468937 187 - 1.448 1.439 -0.032
ENSG00000185920 E026 29.4120389 0.0033682149 2.555704e-02 6.303483e-02 9 95468938 95469153 216 - 1.512 1.411 -0.346
ENSG00000185920 E027 0.0000000       9 95469154 95469189 36 -      
ENSG00000185920 E028 18.2169007 0.0010721250 1.226270e-02 3.416369e-02 9 95469813 95469931 119 - 1.327 1.173 -0.543
ENSG00000185920 E029 0.0000000       9 95474012 95474143 132 -      
ENSG00000185920 E030 18.4071037 0.0052361756 5.069115e-04 2.186143e-03 9 95476034 95476159 126 - 1.365 1.105 -0.920
ENSG00000185920 E031 17.6797858 0.0010676871 4.449887e-05 2.538292e-04 9 95476759 95476857 99 - 1.361 1.058 -1.076
ENSG00000185920 E032 19.0115060 0.0010187265 3.775783e-04 1.687770e-03 9 95477547 95477702 156 - 1.375 1.133 -0.850
ENSG00000185920 E033 20.5126199 0.0085201406 7.105770e-02 1.450970e-01 9 95478055 95478186 132 - 1.361 1.254 -0.374
ENSG00000185920 E034 29.4514408 0.0016680271 1.346532e-02 3.700106e-02 9 95479000 95479147 148 - 1.515 1.403 -0.384
ENSG00000185920 E035 0.0000000       9 95479856 95479968 113 -      
ENSG00000185920 E036 17.1803856 0.0191424596 7.507919e-02 1.516594e-01 9 95479969 95479995 27 - 1.302 1.161 -0.500
ENSG00000185920 E037 20.5296655 0.0125159646 2.110463e-03 7.566776e-03 9 95479996 95480060 65 - 1.405 1.161 -0.857
ENSG00000185920 E038 15.0352955 0.0014744649 4.586965e-05 2.608317e-04 9 95480061 95480090 30 - 1.302 0.966 -1.206
ENSG00000185920 E039 15.7064488 0.0011616272 1.191489e-02 3.332950e-02 9 95480390 95480439 50 - 1.274 1.105 -0.604
ENSG00000185920 E040 15.3404832 0.0033543071 2.098537e-02 5.355808e-02 9 95480440 95480538 99 - 1.263 1.105 -0.563
ENSG00000185920 E041 8.0856095 0.0024387322 1.729692e-03 6.376274e-03 9 95480539 95480543 5 - 1.060 0.728 -1.273
ENSG00000185920 E042 10.7009416 0.0016694949 9.274177e-04 3.710905e-03 9 95480544 95480588 45 - 1.159 0.850 -1.142
ENSG00000185920 E043 0.2965864 0.2500205070 1.515304e-01   9 95481829 95481948 120 - 0.000 0.266 13.063
ENSG00000185920 E044 9.8579308 0.0017337853 1.850424e-02 4.824028e-02 9 95481949 95481965 17 - 1.104 0.900 -0.754
ENSG00000185920 E045 8.4917658 0.0019434708 1.622705e-02 4.322626e-02 9 95481966 95481970 5 - 1.051 0.822 -0.861
ENSG00000185920 E046 12.5035656 0.0014224328 1.679928e-02 4.449224e-02 9 95481971 95482040 70 - 1.187 1.005 -0.659
ENSG00000185920 E047 16.7352765 0.0279785854 1.943098e-02 5.026959e-02 9 95482134 95482203 70 - 1.316 1.092 -0.795
ENSG00000185920 E048 0.0000000       9 95482204 95482238 35 -      
ENSG00000185920 E049 0.0000000       9 95482239 95484309 2071 -      
ENSG00000185920 E050 20.4185308 0.0020095806 2.122358e-04 1.016314e-03 9 95485685 95485823 139 - 1.409 1.160 -0.873
ENSG00000185920 E051 12.5337451 0.0015588141 5.771630e-04 2.449139e-03 9 95485824 95485874 51 - 1.220 0.923 -1.081
ENSG00000185920 E052 0.0000000       9 95494262 95494401 140 -      
ENSG00000185920 E053 0.2955422 0.0292360478 7.466787e-01   9 95503300 95503346 47 - 0.095 0.156 0.829
ENSG00000185920 E054 0.5911862 0.0182356757 9.443134e-02 1.820227e-01 9 95505794 95505878 85 - 0.296 0.000 -14.563
ENSG00000185920 E055 16.8590963 0.0010908863 2.193497e-03 7.821733e-03 9 95506407 95506599 193 - 1.317 1.105 -0.753
ENSG00000185920 E056 0.1472490 0.0425202625 7.288588e-01   9 95506600 95506665 66 - 0.095 0.000 -12.549
ENSG00000185920 E057 0.9859167 0.0950447309 8.022626e-01 8.740334e-01 9 95506937 95507228 292 - 0.295 0.273 -0.155
ENSG00000185920 E058 1.4048617 0.0095105960 2.869195e-01 4.273677e-01 9 95507229 95507231 3 - 0.433 0.271 -0.976
ENSG00000185920 E059 2.3531139 0.0063285146 3.186747e-01 4.616454e-01 9 95507232 95507417 186 - 0.566 0.437 -0.628
ENSG00000185920 E060 1.6980474 0.4333877550 9.926383e-03 2.857982e-02 9 95507934 95507950 17 - 0.000 0.731 14.969
ENSG00000185920 E061 3.9080598 0.0440859077 4.514535e-06 3.246897e-05 9 95507951 95508160 210 - 0.173 1.001 4.210
ENSG00000185920 E062 17.6904805 0.0030605345 6.256294e-01 7.417137e-01 9 95508161 95509266 1106 - 1.251 1.265 0.047
ENSG00000185920 E063 0.4470576 0.0212933542 8.489967e-01 9.062882e-01 9 95516469 95516622 154 - 0.173 0.156 -0.171
ENSG00000185920 E064 1.1124400 0.0115498709 5.655803e-01 6.926461e-01 9 95516623 95517057 435 - 0.346 0.271 -0.491