ENSG00000185917

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332131 ENSG00000185917 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD4 protein_coding protein_coding 14.7913 12.04047 14.12101 1.498486 0.321837 0.2297751 1.8381989 1.7477304 1.7226330 1.11437915 0.39729367 -0.02074772 0.12815833 0.13386667 0.12083333 -0.01303333 0.916406470 0.003572983 FALSE  
ENST00000399207 ENSG00000185917 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD4 protein_coding protein_coding 14.7913 12.04047 14.12101 1.498486 0.321837 0.2297751 1.3599822 1.0775121 0.7603063 0.57970900 0.57389611 -0.49752732 0.08703333 0.08590000 0.05546667 -0.03043333 0.898531368 0.003572983 FALSE  
ENST00000399208 ENSG00000185917 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD4 protein_coding protein_coding 14.7913 12.04047 14.12101 1.498486 0.321837 0.2297751 0.9035940 0.7780851 0.4149092 0.23341749 0.41490920 -0.89119677 0.06323750 0.07050000 0.02973333 -0.04076667 0.258411567 0.003572983 FALSE  
ENST00000399212 ENSG00000185917 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD4 protein_coding protein_coding 14.7913 12.04047 14.12101 1.498486 0.321837 0.2297751 2.0699072 1.8176048 1.8600018 0.22205141 0.04139866 0.03308551 0.14103333 0.15186667 0.13200000 -0.01986667 0.704166674 0.003572983 FALSE  
ENST00000429161 ENSG00000185917 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD4 protein_coding protein_coding 14.7913 12.04047 14.12101 1.498486 0.321837 0.2297751 1.6412811 1.7690992 0.5939553 0.95910176 0.59395533 -1.55863323 0.11005000 0.13250000 0.04030000 -0.09220000 0.482224274 0.003572983 FALSE  
ENST00000481477 ENSG00000185917 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD4 protein_coding processed_transcript 14.7913 12.04047 14.12101 1.498486 0.321837 0.2297751 1.7489064 1.8228654 1.4500052 0.29607229 0.33868149 -0.32812733 0.11910000 0.15620000 0.10383333 -0.05236667 0.589773884 0.003572983 TRUE  
ENST00000487297 ENSG00000185917 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD4 protein_coding retained_intron 14.7913 12.04047 14.12101 1.498486 0.321837 0.2297751 0.8989776 0.3600032 1.2068611 0.02904674 0.14229001 1.71755500 0.05846667 0.03080000 0.08600000 0.05520000 0.003572983 0.003572983 FALSE  
MSTRG.21277.9 ENSG00000185917 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD4 protein_coding   14.7913 12.04047 14.12101 1.498486 0.321837 0.2297751 1.5726036 0.9498791 2.2631421 0.10777991 0.16803101 1.24376325 0.10502917 0.08153333 0.16000000 0.07846667 0.015835287 0.003572983 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185917 E001 0.0000000       21 36034541 36034541 1 -      
ENSG00000185917 E002 243.1352284 0.0051728208 1.733259e-02 4.567481e-02 21 36034542 36035703 1162 - 2.332 2.429 0.321
ENSG00000185917 E003 87.6655153 0.0003318701 1.085643e-01 2.034199e-01 21 36035704 36035960 257 - 1.979 1.926 -0.176
ENSG00000185917 E004 33.4239027 0.0006580445 8.088574e-01 8.786244e-01 21 36035961 36036084 124 - 1.528 1.548 0.071
ENSG00000185917 E005 79.6509599 0.0003862100 7.558038e-01 8.410359e-01 21 36036085 36036251 167 - 1.896 1.914 0.062
ENSG00000185917 E006 24.8721290 0.0009514104 2.436047e-04 1.148414e-03 21 36036518 36036680 163 - 1.528 1.279 -0.861
ENSG00000185917 E007 68.7250820 0.0009495904 7.220848e-01 8.162831e-01 21 36038150 36038273 124 - 1.849 1.839 -0.033
ENSG00000185917 E008 49.5227919 0.0010726069 8.050248e-01 8.759390e-01 21 36040575 36040655 81 - 1.706 1.699 -0.023
ENSG00000185917 E009 38.1189823 0.0027175154 2.139175e-01 3.431530e-01 21 36041807 36041858 52 - 1.628 1.556 -0.243
ENSG00000185917 E010 27.8201533 0.0310011369 7.681857e-01 8.502320e-01 21 36041859 36041888 30 - 1.478 1.437 -0.141
ENSG00000185917 E011 32.4849110 0.0128851048 2.074666e-08 2.411283e-07 21 36041889 36043373 1485 - 1.717 1.247 -1.618
ENSG00000185917 E012 32.4031392 0.0105784786 1.614539e-06 1.281612e-05 21 36043401 36043651 251 - 1.684 1.303 -1.308
ENSG00000185917 E013 3.1761523 0.0521250445 2.840121e-01 4.242245e-01 21 36043686 36043697 12 - 0.716 0.553 -0.707
ENSG00000185917 E014 13.7332895 0.0014251822 2.908149e-01 4.316070e-01 21 36043698 36043781 84 - 1.113 1.214 0.360
ENSG00000185917 E015 104.6938087 0.0004969014 6.955804e-01 7.961600e-01 21 36043782 36043956 175 - 2.014 2.033 0.064
ENSG00000185917 E016 63.8767548 0.0004883431 1.341536e-01 2.399209e-01 21 36045582 36045613 32 - 1.775 1.847 0.242
ENSG00000185917 E017 64.2226208 0.0004307082 1.347957e-01 2.408071e-01 21 36045614 36045630 17 - 1.778 1.849 0.241
ENSG00000185917 E018 102.7722058 0.0051272034 5.701962e-02 1.214931e-01 21 36045631 36045764 134 - 1.965 2.058 0.311
ENSG00000185917 E019 37.7474505 0.0145759074 1.065269e-01 2.004369e-01 21 36045765 36045782 18 - 1.515 1.647 0.450
ENSG00000185917 E020 69.7700735 0.0023357528 1.840123e-02 4.801271e-02 21 36045783 36045863 81 - 1.787 1.902 0.390
ENSG00000185917 E021 89.5239405 0.0003287879 1.027215e-01 1.946437e-01 21 36045864 36046011 148 - 1.924 1.990 0.224
ENSG00000185917 E022 38.7665796 0.0005811283 5.792456e-01 7.041920e-01 21 36048308 36048321 14 - 1.614 1.590 -0.082
ENSG00000185917 E023 60.3868602 0.0058299217 5.953542e-01 7.174676e-01 21 36048322 36048396 75 - 1.768 1.810 0.141
ENSG00000185917 E024 0.7802774 0.0159352265 6.530924e-01 7.636631e-01 21 36052917 36053582 666 - 0.295 0.218 -0.571
ENSG00000185917 E025 44.5683086 0.0010497830 1.805121e-01 3.018259e-01 21 36053583 36053588 6 - 1.618 1.696 0.267
ENSG00000185917 E026 60.4673563 0.0045217118 9.094169e-01 9.464668e-01 21 36053589 36053620 32 - 1.785 1.801 0.055
ENSG00000185917 E027 90.0528300 0.0025965579 5.712140e-01 6.975523e-01 21 36057109 36057204 96 - 1.973 1.956 -0.057
ENSG00000185917 E028 0.7374030 0.0157192467 1.690508e-01 2.869548e-01 21 36057205 36057301 97 - 0.361 0.123 -1.986
ENSG00000185917 E029 6.9476954 0.0156587501 1.576332e-03 5.882277e-03 21 36057384 36057477 94 - 1.079 0.663 -1.612
ENSG00000185917 E030 82.4146919 0.0007688010 2.374403e-01 3.711990e-01 21 36058816 36058924 109 - 1.948 1.908 -0.133
ENSG00000185917 E031 12.8809965 0.0031228778 8.204000e-01 8.867008e-01 21 36058925 36058973 49 - 1.154 1.138 -0.058
ENSG00000185917 E032 8.3984462 0.0022323969 1.689499e-01 2.868162e-01 21 36058974 36059788 815 - 1.043 0.896 -0.546
ENSG00000185917 E033 2.1974312 0.2731812383 6.789856e-01 7.832951e-01 21 36059789 36059821 33 - 0.554 0.434 -0.589
ENSG00000185917 E034 11.7727571 0.0056476655 9.964204e-01 1.000000e+00 21 36059822 36060106 285 - 1.102 1.107 0.016
ENSG00000185917 E035 4.9800982 0.0036147992 1.069848e-01 2.010868e-01 21 36060107 36060261 155 - 0.874 0.663 -0.847
ENSG00000185917 E036 10.0840977 0.0023237595 6.103994e-01 7.297175e-01 21 36060282 36060346 65 - 1.067 1.021 -0.171
ENSG00000185917 E037 54.2614831 0.0023151379 9.160775e-03 2.668452e-02 21 36060347 36060599 253 - 1.809 1.679 -0.441
ENSG00000185917 E038 0.1515154 0.0428098828 4.961505e-01   21 36079305 36079389 85 - 0.122 0.000 -8.788