ENSG00000185904

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000424751 ENSG00000185904 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00839 lncRNA lncRNA 2.951897 3.673021 3.201858 0.4034173 0.03344677 -0.1974813 0.1844596 0.09867462 0.2374009 0.05056993 0.12212208 1.1868360 0.06272917 0.02773333 0.07340000 0.045666667 0.7858731954 0.0003074312 TRUE FALSE
ENST00000429940 ENSG00000185904 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00839 lncRNA lncRNA 2.951897 3.673021 3.201858 0.4034173 0.03344677 -0.1974813 1.0015046 2.38371623 0.7182321 0.51512687 0.23528102 -1.7167819 0.30776667 0.63610000 0.22563333 -0.410466667 0.0163595794 0.0003074312 TRUE TRUE
ENST00000659650 ENSG00000185904 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00839 lncRNA lncRNA 2.951897 3.673021 3.201858 0.4034173 0.03344677 -0.1974813 0.7845334 0.46701465 1.1046544 0.04075281 0.10788111 1.2244910 0.28327917 0.13243333 0.34436667 0.211933333 0.0010656349 0.0003074312 TRUE TRUE
ENST00000662209 ENSG00000185904 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00839 lncRNA lncRNA 2.951897 3.673021 3.201858 0.4034173 0.03344677 -0.1974813 0.2097008 0.08008318 0.3880850 0.02836303 0.04678233 2.1437467 0.07694583 0.02243333 0.12106667 0.098633333 0.0003074312 0.0003074312 FALSE FALSE
ENST00000667964 ENSG00000185904 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00839 lncRNA lncRNA 2.951897 3.673021 3.201858 0.4034173 0.03344677 -0.1974813 0.2002705 0.20530168 0.1663845 0.03320855 0.02520236 -0.2876357 0.07080833 0.05873333 0.05206667 -0.006666667 0.9836753606 0.0003074312   FALSE
ENST00000668072 ENSG00000185904 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00839 lncRNA lncRNA 2.951897 3.673021 3.201858 0.4034173 0.03344677 -0.1974813 0.4463749 0.14209387 0.5488976 0.08748146 0.12747913 1.8776220 0.15639167 0.04193333 0.17160000 0.129666667 0.1414249425 0.0003074312 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185904 E001 1.796281 0.0084814855 7.139274e-01 8.102768e-01 10 42475480 42475542 63 + 0.400 0.471 0.373
ENSG00000185904 E002 2.458455 0.0194374751 8.810649e-01 9.277546e-01 10 42475543 42475553 11 + 0.514 0.546 0.150
ENSG00000185904 E003 12.218810 0.0200880396 2.207003e-02 5.582617e-02 10 42475554 42475627 74 + 0.913 1.187 1.002
ENSG00000185904 E004 13.246541 0.0336902643 1.475724e-02 3.994450e-02 10 42475628 42475641 14 + 0.913 1.229 1.149
ENSG00000185904 E005 44.016960 0.0064350141 5.088750e-04 2.192813e-03 10 42475642 42475880 239 + 1.484 1.712 0.775
ENSG00000185904 E006 2.775279 0.0062602772 6.217798e-02 1.303107e-01 10 42475881 42475964 84 + 0.713 0.428 -1.308
ENSG00000185904 E007 5.694723 0.0030891572 7.231454e-02 1.471938e-01 10 42476068 42476313 246 + 0.933 0.716 -0.849
ENSG00000185904 E008 5.747698 0.0097441810 8.143443e-01 8.823585e-01 10 42476314 42476488 175 + 0.824 0.801 -0.090
ENSG00000185904 E009 2.295953 0.1915135029 7.876078e-01 8.639534e-01 10 42476489 42476530 42 + 0.515 0.481 -0.165
ENSG00000185904 E010 2.736557 0.0747386242 5.026771e-02 1.096382e-01 10 42477062 42477207 146 + 0.743 0.382 -1.688
ENSG00000185904 E011 3.255847 0.0934991075 3.014523e-01 4.432698e-01 10 42477208 42477260 53 + 0.713 0.518 -0.859
ENSG00000185904 E012 45.309993 0.0006117412 1.375381e-02 3.766432e-02 10 42477261 42477442 182 + 1.563 1.701 0.470
ENSG00000185904 E013 9.625465 0.0132813714 3.251706e-03 1.100597e-02 10 42477443 42479325 1883 + 0.743 1.124 1.439
ENSG00000185904 E014 39.945142 0.0090335010 5.937304e-01 7.160665e-01 10 42486979 42487126 148 + 1.622 1.601 -0.070
ENSG00000185904 E015 4.332918 0.0040098259 1.966240e-06 1.531906e-05 10 42489252 42491056 1805 + 1.003 0.326 -3.019
ENSG00000185904 E016 58.290491 0.0291997007 5.545498e-01 6.835162e-01 10 42492080 42492342 263 + 1.781 1.757 -0.081
ENSG00000185904 E017 42.838037 0.0007619923 3.056248e-14 9.359798e-13 10 42492343 42494014 1672 + 1.822 1.449 -1.269
ENSG00000185904 E018 80.254926 0.0097082390 4.715554e-01 6.106690e-01 10 42494015 42495337 1323 + 1.869 1.924 0.185