ENSG00000185896

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332556 ENSG00000185896 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMP1 protein_coding protein_coding 61.23815 65.61428 55.65195 1.916546 0.796505 -0.2375381 44.203379 34.176776 50.50356721 6.6577768 0.49457184 0.5632325 0.72441667 0.51900000 0.907633333 0.38863333 1.398559e-05 2.713265e-06 FALSE TRUE
MSTRG.9095.12 ENSG00000185896 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMP1 protein_coding   61.23815 65.61428 55.65195 1.916546 0.796505 -0.2375381 3.093481 5.967342 1.38868250 0.6048167 0.78790853 -2.0954356 0.04958333 0.09163333 0.024866667 -0.06676667 4.004226e-01 2.713265e-06 FALSE TRUE
MSTRG.9095.8 ENSG00000185896 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMP1 protein_coding   61.23815 65.61428 55.65195 1.916546 0.796505 -0.2375381 9.989075 18.426759 0.08839739 3.1175008 0.08839739 -7.5497494 0.16188750 0.28243333 0.001566667 -0.28086667 2.713265e-06 2.713265e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185896 E001 5.7017240 0.0038920078 4.986758e-05 2.811433e-04 13 113297231 113297238 8 + 1.045 0.536 -2.052
ENSG00000185896 E002 6.1456611 0.0032563974 8.672683e-06 5.844528e-05 13 113297239 113297239 1 + 1.084 0.536 -2.194
ENSG00000185896 E003 102.2355305 0.0295817354 5.038740e-13 1.296271e-11 13 113297240 113297382 143 + 2.265 1.622 -2.165
ENSG00000185896 E004 163.0692601 0.0225062137 1.451857e-06 1.165022e-05 13 113297383 113297495 113 + 2.373 2.032 -1.141
ENSG00000185896 E005 0.4470576 0.0213674974 4.576262e-01 5.979472e-01 13 113297589 113297590 2 + 0.230 0.115 -1.197
ENSG00000185896 E006 0.5922303 0.0179767838 2.289843e-01 3.612233e-01 13 113297591 113297598 8 + 0.311 0.115 -1.781
ENSG00000185896 E007 1.1876829 0.0108238551 1.296928e-02 3.583972e-02 13 113297599 113297737 139 + 0.536 0.115 -3.003
ENSG00000185896 E008 0.0000000       13 113297899 113297975 77 +      
ENSG00000185896 E009 1.1405526 0.0112428123 5.270500e-01 6.602047e-01 13 113304932 113305683 752 + 0.379 0.282 -0.609
ENSG00000185896 E010 1.1792493 0.0144397187 1.661966e-01 2.832549e-01 13 113305684 113305748 65 + 0.438 0.207 -1.513
ENSG00000185896 E011 0.2924217 0.0271483417 1.526737e-01   13 113305749 113305760 12 + 0.229 0.000 -10.427
ENSG00000185896 E012 0.2924217 0.0271483417 1.526737e-01   13 113305761 113305802 42 + 0.229 0.000 -10.427
ENSG00000185896 E013 0.9630129 0.0293521156 5.757631e-01 7.012858e-01 13 113305803 113306484 682 + 0.230 0.345 0.801
ENSG00000185896 E014 345.3312563 0.0031892978 9.211819e-09 1.143312e-07 13 113306485 113306606 122 + 2.617 2.458 -0.528
ENSG00000185896 E015 681.4454212 0.0006793416 7.063708e-09 8.957750e-08 13 113309643 113309862 220 + 2.867 2.795 -0.241
ENSG00000185896 E016 559.6862296 0.0001826620 3.320586e-02 7.820815e-02 13 113310709 113310867 159 + 2.745 2.740 -0.018
ENSG00000185896 E017 185.9718832 0.0003136757 6.524719e-01 7.631683e-01 13 113319469 113319470 2 + 2.256 2.272 0.052
ENSG00000185896 E018 612.8872391 0.0001057299 3.362865e-01 4.801121e-01 13 113319471 113319656 186 + 2.774 2.788 0.047
ENSG00000185896 E019 531.6971271 0.0006702358 7.093709e-01 8.067777e-01 13 113320345 113320470 126 + 2.709 2.730 0.070
ENSG00000185896 E020 39.3128490 0.0005682780 1.414634e-02 3.855811e-02 13 113320471 113321403 933 + 1.655 1.545 -0.375
ENSG00000185896 E021 375.6373881 0.0015644942 8.137689e-01 8.819523e-01 13 113321404 113321470 67 + 2.549 2.584 0.114
ENSG00000185896 E022 651.2975273 0.0001491129 2.140842e-03 7.661776e-03 13 113321557 113321727 171 + 2.764 2.836 0.239
ENSG00000185896 E023 5.6108598 0.0028292074 4.544267e-01 5.950645e-01 13 113321728 113321766 39 + 0.861 0.790 -0.278
ENSG00000185896 E024 7.1016012 0.0320852295 3.837547e-02 8.805647e-02 13 113321767 113321877 111 + 1.046 0.786 -0.984
ENSG00000185896 E025 14.7347275 0.0012306382 7.927096e-02 1.583472e-01 13 113321878 113322281 404 + 1.257 1.130 -0.451
ENSG00000185896 E026 2363.0090774 0.0035283208 1.199700e-09 1.750998e-08 13 113322282 113323672 1391 + 3.273 3.426 0.508