ENSG00000185880

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000560141 ENSG00000185880 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM69 protein_coding processed_transcript 2.490324 1.296415 2.916273 0.2284008 0.2755717 1.163451 1.3716091 1.224918 1.469076 0.2323598 0.1085576 0.2602814 0.6279000 0.9408333 0.5168667 -0.4239667 3.558938e-05 6.730662e-06 TRUE FALSE
MSTRG.10672.2 ENSG00000185880 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM69 protein_coding   2.490324 1.296415 2.916273 0.2284008 0.2755717 1.163451 0.8476689 0.000000 1.315611 0.0000000 0.3894258 7.0505133 0.2720417 0.0000000 0.4343667 0.4343667 6.730662e-06 6.730662e-06 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185880 E001 0.0000000       15 44728988 44729000 13 +      
ENSG00000185880 E002 0.1451727 0.0443885279 6.799253e-01   15 44729001 44729054 54 + 0.109 0.000 -10.968
ENSG00000185880 E003 1.5123819 0.0096027070 8.637321e-01 9.161382e-01 15 44729055 44729072 18 + 0.433 0.395 -0.202
ENSG00000185880 E004 5.3291385 0.0031183230 3.843359e-01 5.284972e-01 15 44729073 44729141 69 + 0.861 0.737 -0.490
ENSG00000185880 E005 15.2599386 0.0011752438 6.202103e-01 7.374719e-01 15 44729142 44729349 208 + 1.243 1.190 -0.189
ENSG00000185880 E006 16.3049977 0.0129710747 1.596801e-02 4.265739e-02 15 44729350 44729552 203 + 1.344 1.107 -0.839
ENSG00000185880 E007 40.4573788 0.0020373773 6.298294e-02 1.316811e-01 15 44731363 44731930 568 + 1.673 1.568 -0.360
ENSG00000185880 E008 71.1311235 0.0004802025 2.693728e-06 2.037688e-05 15 44731931 44734000 2070 + 1.798 1.929 0.442
ENSG00000185880 E009 0.0000000       15 44736342 44736445 104 +      
ENSG00000185880 E010 0.0000000       15 44736446 44736482 37 +      
ENSG00000185880 E011 0.1451727 0.0443885279 6.799253e-01   15 44736483 44736527 45 + 0.109 0.000 -12.551
ENSG00000185880 E012 0.1451727 0.0443885279 6.799253e-01   15 44736528 44736529 2 + 0.109 0.000 -12.551
ENSG00000185880 E013 0.1451727 0.0443885279 6.799253e-01   15 44736530 44736534 5 + 0.109 0.000 -12.551
ENSG00000185880 E014 0.1451727 0.0443885279 6.799253e-01   15 44736535 44736560 26 + 0.109 0.000 -12.551
ENSG00000185880 E015 0.1451727 0.0443885279 6.799253e-01   15 44736561 44736565 5 + 0.109 0.000 -12.551
ENSG00000185880 E016 0.2966881 0.0290785164 3.140092e-01   15 44736566 44736710 145 + 0.196 0.000 -13.465
ENSG00000185880 E017 0.1451727 0.0443885279 6.799253e-01   15 44752918 44754899 1982 + 0.109 0.000 -12.551
ENSG00000185880 E018 1.3286012 0.1780499661 5.888593e-01 7.120141e-01 15 44754900 44755376 477 + 0.432 0.319 -0.652
ENSG00000185880 E019 0.2903454 0.3507115137 4.161408e-01   15 44756368 44756463 96 + 0.195 0.000 -13.041
ENSG00000185880 E020 1.3339844 0.6935797108 8.134974e-01 8.817526e-01 15 44756464 44758612 2149 + 0.269 0.425 0.952
ENSG00000185880 E021 0.1515154 0.0435351831 6.802470e-01   15 44758613 44758620 8 + 0.109 0.000 -12.553
ENSG00000185880 E022 1.0287911 0.0152449004 7.054915e-01 8.038543e-01 15 44758621 44758773 153 + 0.268 0.326 0.387
ENSG00000185880 E023 0.8772757 0.0187972998 4.297975e-01 5.724600e-01 15 44758774 44758803 30 + 0.196 0.326 0.973
ENSG00000185880 E024 0.6558305 0.2281112917 7.660065e-01 8.486213e-01 15 44758804 44758854 51 + 0.196 0.242 0.394
ENSG00000185880 E025 0.2903454 0.3507115137 4.161408e-01   15 44759640 44759662 23 + 0.195 0.000 -13.041
ENSG00000185880 E026 0.1451727 0.0443885279 6.799253e-01   15 44759748 44759872 125 + 0.109 0.000 -12.551
ENSG00000185880 E027 1.8801457 0.0413050871 5.619249e-01 6.896450e-01 15 44767231 44767829 599 + 0.516 0.395 -0.617