ENSG00000185813

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000538721 ENSG00000185813 HEK293_OSMI2_2hA HEK293_TMG_2hB PCYT2 protein_coding protein_coding 47.42226 92.57194 22.45412 5.593293 0.8979457 -2.043108 6.497665 14.610499 2.449029 1.3895451 0.8553386 -2.5718317 0.12537917 0.15773333 0.1081000 -0.04963333 5.284634e-01 1.12918e-06 FALSE  
ENST00000538936 ENSG00000185813 HEK293_OSMI2_2hA HEK293_TMG_2hB PCYT2 protein_coding protein_coding 47.42226 92.57194 22.45412 5.593293 0.8979457 -2.043108 12.111144 21.338610 5.557198 1.1803213 0.2113822 -1.9391189 0.25901667 0.23066667 0.2475000 0.01683333 5.806351e-01 1.12918e-06 FALSE  
ENST00000571105 ENSG00000185813 HEK293_OSMI2_2hA HEK293_TMG_2hB PCYT2 protein_coding protein_coding 47.42226 92.57194 22.45412 5.593293 0.8979457 -2.043108 11.282356 25.765828 4.321382 2.0554232 0.5051638 -2.5731193 0.21705833 0.27796667 0.1940333 -0.08393333 1.539947e-01 1.12918e-06 FALSE  
ENST00000572995 ENSG00000185813 HEK293_OSMI2_2hA HEK293_TMG_2hB PCYT2 protein_coding protein_coding 47.42226 92.57194 22.45412 5.593293 0.8979457 -2.043108 7.145437 15.942148 2.052056 0.8518192 0.1071647 -2.9515954 0.13844583 0.17383333 0.0913000 -0.08253333 7.245940e-04 1.12918e-06 FALSE  
ENST00000574155 ENSG00000185813 HEK293_OSMI2_2hA HEK293_TMG_2hB PCYT2 protein_coding retained_intron 47.42226 92.57194 22.45412 5.593293 0.8979457 -2.043108 2.539855 2.837936 2.088953 0.4381552 0.2251029 -0.4402466 0.06991667 0.03033333 0.0930000 0.06266667 1.129180e-06 1.12918e-06    
ENST00000576343 ENSG00000185813 HEK293_OSMI2_2hA HEK293_TMG_2hB PCYT2 protein_coding protein_coding 47.42226 92.57194 22.45412 5.593293 0.8979457 -2.043108 4.106202 7.945411 3.659826 1.2495085 0.5794073 -1.1162247 0.08990000 0.08570000 0.1623000 0.07660000 4.377361e-02 1.12918e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185813 E001 1266.896006 7.447377e-05 3.229094e-09 4.355587e-08 17 81900958 81904325 3368 - 3.001 2.930 -0.234
ENSG00000185813 E002 177.924338 1.447990e-03 3.506576e-01 4.948419e-01 17 81904326 81904342 17 - 2.055 2.100 0.153
ENSG00000185813 E003 214.224395 4.035224e-04 5.623872e-01 6.899959e-01 17 81904343 81904366 24 - 2.150 2.176 0.088
ENSG00000185813 E004 230.988446 1.035883e-03 1.135777e-01 2.107501e-01 17 81904367 81904423 57 - 2.150 2.215 0.216
ENSG00000185813 E005 492.602778 2.413869e-03 2.606113e-03 9.082752e-03 17 81904424 81904635 212 - 2.439 2.547 0.359
ENSG00000185813 E006 202.422888 2.999150e-03 1.339203e-03 5.107254e-03 17 81904636 81904650 15 - 2.013 2.169 0.521
ENSG00000185813 E007 516.854149 5.345315e-03 1.826325e-04 8.892560e-04 17 81904651 81904811 161 - 2.408 2.574 0.553
ENSG00000185813 E008 401.315955 1.333268e-03 9.921032e-06 6.600098e-05 17 81904812 81904875 64 - 2.312 2.461 0.496
ENSG00000185813 E009 296.400239 2.580026e-04 3.199987e-05 1.890858e-04 17 81904876 81904897 22 - 2.191 2.327 0.455
ENSG00000185813 E010 406.292560 1.215388e-03 1.863554e-01 3.091730e-01 17 81904898 81904944 47 - 2.409 2.456 0.157
ENSG00000185813 E011 540.976542 7.154568e-04 6.500898e-01 7.611857e-01 17 81905066 81905154 89 - 2.557 2.576 0.061
ENSG00000185813 E012 401.144997 1.546189e-04 7.016073e-01 8.006978e-01 17 81905382 81905447 66 - 2.445 2.442 -0.012
ENSG00000185813 E013 2.054459 1.919811e-01 4.364018e-01 5.784828e-01 17 81905448 81905518 71 - 0.506 0.344 -0.868
ENSG00000185813 E014 4.020197 1.222961e-01 8.789198e-01 9.262062e-01 17 81905519 81905669 151 - 0.506 0.570 0.298
ENSG00000185813 E015 255.579515 1.733776e-04 7.157989e-01 8.116288e-01 17 81905670 81905680 11 - 2.232 2.249 0.057
ENSG00000185813 E016 378.673873 1.547638e-04 3.041685e-01 4.461844e-01 17 81905681 81905735 55 - 2.388 2.420 0.108
ENSG00000185813 E017 15.454979 1.145175e-03 4.947286e-07 4.378847e-06 17 81905736 81906099 364 - 1.427 0.958 -1.671
ENSG00000185813 E018 312.213163 2.935131e-04 5.127272e-01 6.476247e-01 17 81906100 81906144 45 - 2.345 2.332 -0.042
ENSG00000185813 E019 283.227233 7.214566e-04 4.827657e-02 1.061199e-01 17 81906145 81906177 33 - 2.339 2.285 -0.180
ENSG00000185813 E020 34.104009 3.030475e-03 7.333117e-11 1.322957e-09 17 81906178 81906463 286 - 1.737 1.284 -1.556
ENSG00000185813 E021 398.948830 8.185878e-04 8.210174e-01 8.871749e-01 17 81906464 81906546 83 - 2.440 2.441 0.001
ENSG00000185813 E022 446.923717 1.501939e-03 6.050002e-01 7.254357e-01 17 81906760 81906898 139 - 2.471 2.494 0.077
ENSG00000185813 E023 9.566710 1.798492e-03 9.714004e-02 1.861058e-01 17 81907204 81907257 54 - 1.053 0.848 -0.765
ENSG00000185813 E024 304.818586 2.721963e-03 7.247322e-01 8.181871e-01 17 81907554 81907598 45 - 2.327 2.323 -0.015
ENSG00000185813 E025 6.047719 1.007040e-01 1.184983e-02 3.317200e-02 17 81907599 81907772 174 - 1.053 0.603 -1.775
ENSG00000185813 E026 236.109708 4.126890e-03 6.496046e-01 7.608384e-01 17 81907773 81907785 13 - 2.224 2.212 -0.041
ENSG00000185813 E027 351.169295 2.645765e-04 5.461748e-01 6.763972e-01 17 81907786 81907857 72 - 2.392 2.381 -0.034
ENSG00000185813 E028 345.683360 1.489565e-03 3.666186e-01 5.109628e-01 17 81908568 81908634 67 - 2.395 2.375 -0.069
ENSG00000185813 E029 191.475719 8.990325e-04 4.204686e-01 5.636725e-01 17 81908876 81908877 2 - 2.141 2.117 -0.080
ENSG00000185813 E030 289.455480 4.372245e-04 2.324289e-01 3.653308e-01 17 81908878 81908918 41 - 2.326 2.297 -0.098
ENSG00000185813 E031 317.762095 1.849302e-04 1.464187e-01 2.568101e-01 17 81908919 81908996 78 - 2.370 2.336 -0.113
ENSG00000185813 E032 226.569724 1.073333e-03 1.516921e-01 2.639624e-01 17 81908997 81909037 41 - 2.230 2.187 -0.146
ENSG00000185813 E033 3.983492 3.934313e-03 2.347198e-01 3.680308e-01 17 81909038 81909161 124 - 0.733 0.538 -0.847
ENSG00000185813 E034 5.231640 4.812565e-03 7.948437e-03 2.364879e-02 17 81909162 81909321 160 - 0.958 0.573 -1.559
ENSG00000185813 E035 241.527764 1.005976e-03 2.868865e-03 9.879625e-03 17 81909514 81909602 89 - 2.301 2.209 -0.310
ENSG00000185813 E036 2.801109 8.275190e-03 6.799903e-01 7.840206e-01 17 81910901 81911015 115 - 0.393 0.480 0.458
ENSG00000185813 E037 1.256566 1.243972e-02 1.000109e-01 1.905033e-01 17 81911016 81911266 251 - 0.506 0.198 -1.932
ENSG00000185813 E038 140.814764 1.226944e-02 4.804716e-02 1.057151e-01 17 81911267 81911432 166 - 2.090 1.973 -0.392