ENSG00000185808

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360525 ENSG00000185808 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGP protein_coding protein_coding 37.13226 49.13752 40.5547 0.9046767 0.7302747 -0.2768938 27.034583 36.600181 26.785793 0.7925826 0.8114880 -0.45023840 0.7285042 0.7448667 0.6602667 -0.0846 0.002871095 0.0001395117 FALSE  
ENST00000399098 ENSG00000185808 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGP protein_coding protein_coding 37.13226 49.13752 40.5547 0.9046767 0.7302747 -0.2768938 5.543349 6.692336 6.684613 0.3700068 0.9866007 -0.00166333 0.1504125 0.1361000 0.1657000 0.0296 0.724943649 0.0001395117 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185808 E001 28.045134 0.0046611586 8.344523e-13 2.075605e-11 21 37062846 37065373 2528 - 1.699 1.180 -1.795
ENSG00000185808 E002 390.618489 0.0012009876 1.278298e-02 3.540182e-02 21 37065374 37065712 339 - 2.547 2.602 0.183
ENSG00000185808 E003 423.861790 0.0001561804 6.411668e-01 7.542715e-01 21 37067262 37067380 119 - 2.610 2.619 0.028
ENSG00000185808 E004 2.549593 0.0507003295 1.009971e-01 1.919848e-01 21 37069267 37069551 285 - 0.709 0.427 -1.297
ENSG00000185808 E005 370.426818 0.0001848960 5.556819e-01 6.845152e-01 21 37069552 37069624 73 - 2.549 2.561 0.037
ENSG00000185808 E006 81.269511 0.0058768046 1.658919e-01 2.828516e-01 21 37072145 37072310 166 - 1.948 1.876 -0.241
ENSG00000185808 E007 352.830858 0.0002656048 4.210669e-01 5.642112e-01 21 37072434 37072537 104 - 2.525 2.541 0.052
ENSG00000185808 E008 30.459106 0.0007540782 1.122946e-03 4.380314e-03 21 37072538 37072847 310 - 1.593 1.389 -0.700
ENSG00000185808 E009 14.044591 0.0274921734 2.859616e-02 6.920350e-02 21 37072848 37072990 143 - 1.302 1.042 -0.929
ENSG00000185808 E010 5.961660 0.0030013144 4.823970e-02 1.060587e-01 21 37072991 37072999 9 - 0.965 0.720 -0.956
ENSG00000185808 E011 184.747207 0.0002812462 6.872576e-01 7.896347e-01 21 37073000 37073170 171 - 2.248 2.259 0.038