ENSG00000185803

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000527078 ENSG00000185803 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC52A2 protein_coding protein_coding 76.5386 118.022 49.98853 5.671465 1.543407 -1.239221 8.192622 9.865011 7.557738 2.365456 0.2463354 -0.3839203 0.1060875 0.08273333 0.15120000 0.06846667 0.071088501 0.002008576 FALSE TRUE
ENST00000530047 ENSG00000185803 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC52A2 protein_coding protein_coding 76.5386 118.022 49.98853 5.671465 1.543407 -1.239221 20.588868 40.351145 8.482017 2.383881 1.3712916 -2.2487880 0.2666292 0.34380000 0.16886667 -0.17493333 0.003914578 0.002008576 FALSE TRUE
ENST00000534725 ENSG00000185803 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC52A2 protein_coding protein_coding 76.5386 118.022 49.98853 5.671465 1.543407 -1.239221 4.757829 5.887178 3.688906 1.248733 0.1724708 -0.6729260 0.0603875 0.04913333 0.07376667 0.02463333 0.260276360 0.002008576 FALSE TRUE
ENST00000643944 ENSG00000185803 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC52A2 protein_coding protein_coding 76.5386 118.022 49.98853 5.671465 1.543407 -1.239221 34.727087 50.024144 24.192288 3.616938 1.5996415 -1.0477695 0.4598833 0.42283333 0.48540000 0.06256667 0.523477807 0.002008576 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185803 E001 0.3332198 2.744240e-02 5.090375e-01   8 144333957 144334111 155 + 0.181 0.081 -1.332
ENSG00000185803 E002 0.1451727 4.277323e-02 1.949662e-01   8 144354135 144354311 177 + 0.181 0.000 -10.561
ENSG00000185803 E003 0.0000000       8 144354644 144354652 9 +      
ENSG00000185803 E004 0.2214452 3.754709e-02 1.000000e+00   8 144354653 144354690 38 + 0.000 0.081 8.122
ENSG00000185803 E005 0.0000000       8 144354691 144354845 155 +      
ENSG00000185803 E006 0.0000000       8 144354990 144355383 394 +      
ENSG00000185803 E007 0.0000000       8 144357251 144357602 352 +      
ENSG00000185803 E008 0.8512514 1.446525e-02 6.599744e-01 7.686999e-01 8 144358557 144358564 8 + 0.181 0.260 0.667
ENSG00000185803 E009 3.8039904 4.306059e-03 8.745542e-01 9.233423e-01 8 144358565 144358569 5 + 0.613 0.632 0.083
ENSG00000185803 E010 7.4804160 2.234151e-03 2.862610e-01 4.266619e-01 8 144358570 144358576 7 + 0.967 0.829 -0.524
ENSG00000185803 E011 11.4942975 1.730725e-03 6.001818e-01 7.214589e-01 8 144358577 144358580 4 + 1.074 1.010 -0.231
ENSG00000185803 E012 26.4795244 1.097133e-02 6.385917e-01 7.521950e-01 8 144358581 144358585 5 + 1.403 1.358 -0.156
ENSG00000185803 E013 38.7077026 2.654360e-03 2.739186e-01 4.130166e-01 8 144358586 144358592 7 + 1.588 1.509 -0.269
ENSG00000185803 E014 39.8387033 4.341385e-03 2.494225e-01 3.852458e-01 8 144358593 144358593 1 + 1.605 1.520 -0.288
ENSG00000185803 E015 41.7596326 4.656881e-03 1.829851e-01 3.049355e-01 8 144358594 144358594 1 + 1.632 1.537 -0.324
ENSG00000185803 E016 93.4146715 3.442256e-04 3.349230e-03 1.128939e-02 8 144358595 144358603 9 + 1.996 1.871 -0.421
ENSG00000185803 E017 101.1455532 4.123490e-04 7.452227e-04 3.061614e-03 8 144358604 144358605 2 + 2.039 1.901 -0.464
ENSG00000185803 E018 115.8753627 3.314954e-03 2.259004e-03 8.027341e-03 8 144358606 144358610 5 + 2.102 1.960 -0.478
ENSG00000185803 E019 57.5705636 1.691471e-02 3.335960e-06 2.473146e-05 8 144358611 144358612 2 + 1.944 1.579 -1.233
ENSG00000185803 E020 85.5736618 1.032242e-02 1.977111e-09 2.771423e-08 8 144358613 144358623 11 + 2.120 1.742 -1.269
ENSG00000185803 E021 100.4176132 1.484080e-02 1.572272e-07 1.537671e-06 8 144358624 144358627 4 + 2.180 1.818 -1.214
ENSG00000185803 E022 138.4017278 2.029549e-02 1.612337e-05 1.021717e-04 8 144358628 144358658 31 + 2.295 1.974 -1.076
ENSG00000185803 E023 228.7086815 1.896797e-02 3.190289e-04 1.457065e-03 8 144358659 144358722 64 + 2.470 2.219 -0.838
ENSG00000185803 E024 287.1168507 5.363656e-03 1.640493e-05 1.037685e-04 8 144358723 144358783 61 + 2.522 2.341 -0.603
ENSG00000185803 E025 403.1107947 2.771255e-03 1.579840e-03 5.893393e-03 8 144358784 144358900 117 + 2.615 2.512 -0.344
ENSG00000185803 E026 352.4660709 2.387455e-04 6.253915e-01 7.415429e-01 8 144358901 144358989 89 + 2.493 2.474 -0.061
ENSG00000185803 E027 261.0284636 1.715174e-04 6.466652e-01 7.585038e-01 8 144358990 144359011 22 + 2.364 2.345 -0.065
ENSG00000185803 E028 358.3466518 1.790232e-04 2.672554e-01 4.055520e-01 8 144359012 144359065 54 + 2.510 2.479 -0.105
ENSG00000185803 E029 9.3123345 3.374398e-03 6.873537e-02 1.412701e-01 8 144359066 144359183 118 + 1.092 0.879 -0.789
ENSG00000185803 E030 272.7748552 4.244500e-04 7.973070e-01 8.706688e-01 8 144359184 144359187 4 + 2.371 2.370 -0.003
ENSG00000185803 E031 450.5703848 2.175238e-04 4.695272e-01 6.087539e-01 8 144359188 144359233 46 + 2.582 2.588 0.022
ENSG00000185803 E032 642.4552270 9.718245e-05 6.927570e-01 7.939116e-01 8 144359234 144359320 87 + 2.750 2.736 -0.047
ENSG00000185803 E033 637.7478969 1.454624e-04 6.096955e-01 7.291315e-01 8 144359321 144359423 103 + 2.735 2.736 0.003
ENSG00000185803 E034 4.8146758 5.506213e-03 6.198098e-03 1.913674e-02 8 144359424 144359521 98 + 0.967 0.588 -1.525
ENSG00000185803 E035 585.0385993 1.272674e-04 4.476828e-02 9.978379e-02 8 144359623 144359726 104 + 2.680 2.706 0.088
ENSG00000185803 E036 372.4762761 1.600482e-04 6.899139e-03 2.096265e-02 8 144359727 144359747 21 + 2.465 2.515 0.168
ENSG00000185803 E037 776.9405742 8.881901e-05 8.613872e-08 8.852993e-07 8 144359748 144359940 193 + 2.767 2.839 0.239
ENSG00000185803 E038 712.7196510 1.648079e-04 5.100178e-04 2.197188e-03 8 144359941 144360114 174 + 2.749 2.797 0.159
ENSG00000185803 E039 487.5880079 7.303493e-04 6.060509e-01 7.263103e-01 8 144360115 144360171 57 + 2.618 2.624 0.018
ENSG00000185803 E040 1210.5164981 1.984225e-03 8.502802e-02 1.674495e-01 8 144360172 144360493 322 + 2.991 3.027 0.119
ENSG00000185803 E041 10.7338915 1.700961e-03 8.100455e-01 8.794275e-01 8 144360494 144360589 96 + 0.990 1.010 0.073
ENSG00000185803 E042 358.8273098 2.395552e-03 1.567269e-02 4.200707e-02 8 144360590 144360600 11 + 2.434 2.507 0.244
ENSG00000185803 E043 634.4060899 1.230251e-03 3.458572e-06 2.554847e-05 8 144360601 144360713 113 + 2.657 2.760 0.343
ENSG00000185803 E044 1230.9962475 2.939830e-03 1.130244e-03 4.405336e-03 8 144360803 144361286 484 + 2.962 3.045 0.279