ENSG00000185787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000426013 ENSG00000185787 HEK293_OSMI2_2hA HEK293_TMG_2hB MORF4L1 protein_coding protein_coding 227.4205 170.3422 332.7172 26.03768 10.25827 0.9658189 99.04595 102.03777 121.9409692 19.520356 4.9336850 0.2570566 0.4648583 0.5925667 0.3665667 -0.2260000 1.207248e-09 9.466175e-13 FALSE TRUE
ENST00000558502 ENSG00000185787 HEK293_OSMI2_2hA HEK293_TMG_2hB MORF4L1 protein_coding protein_coding 227.4205 170.3422 332.7172 26.03768 10.25827 0.9658189 13.07689 27.77180 0.9844056 9.035603 0.9844056 -4.8041618 0.0799500 0.1596333 0.0028000 -0.1568333 5.449140e-03 9.466175e-13 FALSE TRUE
MSTRG.11325.6 ENSG00000185787 HEK293_OSMI2_2hA HEK293_TMG_2hB MORF4L1 protein_coding   227.4205 170.3422 332.7172 26.03768 10.25827 0.9658189 99.23703 33.20565 182.2217833 6.176664 3.9133271 2.4558397 0.3895542 0.2053333 0.5482000 0.3428667 1.499807e-04 9.466175e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185787 E001 0.0000000       15 78810487 78811041 555 +      
ENSG00000185787 E002 0.0000000       15 78840552 78840675 124 +      
ENSG00000185787 E003 0.2955422 2.795717e-02 7.176759e-01   15 78847667 78848081 415 + 0.096 0.155 0.793
ENSG00000185787 E004 0.1515154 4.334289e-02 8.199565e-01   15 78872814 78872815 2 + 0.096 0.001 -7.356
ENSG00000185787 E005 7.2028327 1.124750e-01 7.488846e-02 1.513500e-01 15 78872816 78872886 71 + 0.737 1.062 1.241
ENSG00000185787 E006 7.3500817 1.163821e-01 9.504668e-02 1.829407e-01 15 78872887 78872889 3 + 0.757 1.063 1.164
ENSG00000185787 E007 9.6503314 8.311143e-02 2.863052e-01 4.267040e-01 15 78872890 78872953 64 + 0.939 1.107 0.617
ENSG00000185787 E008 15.9422691 1.133292e-03 4.221686e-04 1.859275e-03 15 78872954 78872972 19 + 1.322 1.018 -1.085
ENSG00000185787 E009 23.8630017 7.602014e-04 1.041349e-07 1.054074e-06 15 78872973 78872974 2 + 1.513 1.114 -1.397
ENSG00000185787 E010 37.9738466 7.757467e-04 1.424631e-06 1.144581e-05 15 78872975 78872983 9 + 1.681 1.405 -0.942
ENSG00000185787 E011 64.8768186 3.974257e-04 6.476548e-09 8.275191e-08 15 78872984 78872986 3 + 1.902 1.650 -0.850
ENSG00000185787 E012 280.0857722 2.718931e-03 5.922627e-05 3.276078e-04 15 78872987 78873004 18 + 2.491 2.370 -0.403
ENSG00000185787 E013 447.1499483 5.319180e-03 8.036856e-05 4.296642e-04 15 78873005 78873024 20 + 2.701 2.552 -0.498
ENSG00000185787 E014 549.8580249 3.884926e-03 4.237041e-07 3.802258e-06 15 78873025 78873029 5 + 2.796 2.631 -0.549
ENSG00000185787 E015 709.0170137 1.821545e-03 5.214331e-10 8.137732e-09 15 78873030 78873042 13 + 2.900 2.757 -0.475
ENSG00000185787 E016 793.8961450 1.883178e-03 1.916592e-07 1.843203e-06 15 78873043 78873057 15 + 2.940 2.823 -0.389
ENSG00000185787 E017 4.7617760 3.483626e-03 1.615289e-01 2.770966e-01 15 78873058 78873118 61 + 0.825 0.646 -0.729
ENSG00000185787 E018 1.2449272 7.319008e-02 4.998105e-01 6.360785e-01 15 78873119 78873218 100 + 0.394 0.269 -0.786
ENSG00000185787 E019 0.4751703 2.058320e-02 3.178142e-01 4.607110e-01 15 78873723 78873820 98 + 0.096 0.269 1.794
ENSG00000185787 E020 0.4720498 1.750831e-01 9.843423e-01 9.942909e-01 15 78873821 78873839 19 + 0.174 0.155 -0.198
ENSG00000185787 E021 0.3268771 3.069801e-02 7.101711e-01   15 78873840 78873920 81 + 0.096 0.155 0.796
ENSG00000185787 E022 0.8512514 1.447707e-02 5.684101e-02 1.211875e-01 15 78876492 78876586 95 + 0.096 0.434 2.795
ENSG00000185787 E023 0.3332198 2.707464e-02 7.114456e-01   15 78877765 78877777 13 + 0.096 0.155 0.796
ENSG00000185787 E024 0.6330284 4.845870e-02 6.327974e-01 7.475917e-01 15 78877778 78877960 183 + 0.174 0.268 0.791
ENSG00000185787 E025 957.3146641 2.101058e-03 1.385540e-06 1.115729e-05 15 78878213 78878239 27 + 3.018 2.908 -0.367
ENSG00000185787 E026 945.1914814 1.043961e-03 5.293342e-12 1.152653e-10 15 78878240 78878259 20 + 3.018 2.896 -0.405
ENSG00000185787 E027 1351.7693133 3.151557e-04 1.504077e-19 9.141572e-18 15 78880512 78880579 68 + 3.166 3.067 -0.327
ENSG00000185787 E028 28.8570688 1.417109e-03 9.300898e-01 9.600025e-01 15 78884967 78884969 3 + 1.472 1.491 0.064
ENSG00000185787 E029 74.7107932 2.968025e-03 1.546528e-03 5.786217e-03 15 78884970 78885083 114 + 1.931 1.800 -0.441
ENSG00000185787 E030 1637.4326440 2.358432e-04 3.150570e-11 6.042990e-10 15 78886141 78886227 87 + 3.234 3.177 -0.187
ENSG00000185787 E031 2.6009756 1.149083e-02 4.695040e-01 6.087322e-01 15 78886228 78886395 168 + 0.598 0.497 -0.471
ENSG00000185787 E032 1475.0077278 1.184401e-04 8.773562e-01 9.252171e-01 15 78887269 78887349 81 + 3.158 3.181 0.077
ENSG00000185787 E033 5.1931796 4.425968e-02 4.001621e-01 5.438723e-01 15 78887350 78887443 94 + 0.840 0.720 -0.480
ENSG00000185787 E034 4.5744485 1.218361e-01 2.358500e-01 3.693780e-01 15 78890642 78890988 347 + 0.827 0.557 -1.133
ENSG00000185787 E035 1005.7763877 5.901695e-04 1.188947e-02 3.326821e-02 15 78890989 78891014 26 + 2.975 3.035 0.198
ENSG00000185787 E036 11.0436445 1.961369e-03 6.166082e-01 7.346274e-01 15 78891015 78891483 469 + 1.083 1.053 -0.111
ENSG00000185787 E037 1439.6133814 8.906099e-05 7.189292e-01 8.139187e-01 15 78891484 78891551 68 + 3.149 3.168 0.062
ENSG00000185787 E038 1039.6644512 1.009553e-04 4.987375e-03 1.589388e-02 15 78891552 78891572 21 + 3.020 3.009 -0.036
ENSG00000185787 E039 2.8192012 6.844082e-03 1.187653e-01 2.181834e-01 15 78891573 78891705 133 + 0.673 0.433 -1.114
ENSG00000185787 E040 1721.9843838 5.269364e-05 1.623148e-02 4.323502e-02 15 78892212 78892313 102 + 3.235 3.236 0.004
ENSG00000185787 E041 6.5157558 2.162415e-02 5.848387e-04 2.477548e-03 15 78892314 78893018 705 + 1.017 0.497 -2.132
ENSG00000185787 E042 1490.0638662 3.860738e-04 2.339021e-01 3.670160e-01 15 78893539 78893627 89 + 3.157 3.191 0.114
ENSG00000185787 E043 2166.3917363 4.479743e-04 8.131885e-05 4.342056e-04 15 78894058 78894230 173 + 3.304 3.371 0.221
ENSG00000185787 E044 6.2117153 2.571297e-03 1.749218e-01 2.945741e-01 15 78894231 78894753 523 + 0.912 0.757 -0.603
ENSG00000185787 E045 1526.1780105 3.721905e-04 6.192820e-08 6.550959e-07 15 78894820 78894904 85 + 3.143 3.232 0.296
ENSG00000185787 E046 2.2538463 6.938035e-03 1.252596e-02 3.479836e-02 15 78894905 78894908 4 + 0.298 0.723 2.115
ENSG00000185787 E047 1461.4551724 2.642103e-04 4.487501e-09 5.899149e-08 15 78896983 78897100 118 + 3.124 3.215 0.301
ENSG00000185787 E048 3053.4651438 2.974021e-03 3.114943e-17 1.426436e-15 15 78897101 78898139 1039 + 3.372 3.597 0.749
ENSG00000185787 E049 0.0000000       15 78917445 78917493 49 +