ENSG00000185753

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327877 ENSG00000185753 HEK293_OSMI2_2hA HEK293_TMG_2hB CXorf38 protein_coding protein_coding 7.135466 4.415664 9.782034 0.5540433 0.2374953 1.145715 5.2136491 3.8811208 7.2399501 0.50615996 0.30598420 0.8977853 0.7397375 0.87850000 0.74036667 -0.138133333 0.0250489 0.0250489 FALSE TRUE
ENST00000378421 ENSG00000185753 HEK293_OSMI2_2hA HEK293_TMG_2hB CXorf38 protein_coding protein_coding 7.135466 4.415664 9.782034 0.5540433 0.2374953 1.145715 0.3027487 0.1063237 0.2747906 0.01524023 0.06196615 1.2917559 0.0521625 0.02546667 0.02840000 0.002933333 0.9010914 0.0250489 FALSE TRUE
ENST00000378426 ENSG00000185753 HEK293_OSMI2_2hA HEK293_TMG_2hB CXorf38 protein_coding protein_coding 7.135466 4.415664 9.782034 0.5540433 0.2374953 1.145715 0.3775660 0.1145861 0.4560778 0.01483550 0.02626170 1.9034281 0.0618500 0.02596667 0.04656667 0.020600000 0.3472123 0.0250489 FALSE TRUE
MSTRG.34108.3 ENSG00000185753 HEK293_OSMI2_2hA HEK293_TMG_2hB CXorf38 protein_coding   7.135466 4.415664 9.782034 0.5540433 0.2374953 1.145715 1.2226047 0.3136331 1.8112154 0.10215036 0.34727649 2.4924704 0.1437667 0.07006667 0.18466667 0.114600000 0.0941390 0.0250489 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185753 E001 243.605273 0.0004649000 8.050426e-14 2.321353e-12 X 40626921 40628296 1376 - 2.316 2.474 0.527
ENSG00000185753 E002 54.625167 0.0027694533 9.801159e-01 9.915932e-01 X 40628297 40628425 129 - 1.742 1.741 -0.004
ENSG00000185753 E003 67.404848 0.0003544902 9.380303e-01 9.650596e-01 X 40628426 40628576 151 - 1.832 1.828 -0.012
ENSG00000185753 E004 160.328092 0.0002940593 6.597873e-01 7.685456e-01 X 40628577 40629567 991 - 2.209 2.197 -0.041
ENSG00000185753 E005 63.313962 0.0064275659 5.809667e-01 7.056051e-01 X 40629568 40629936 369 - 1.816 1.775 -0.139
ENSG00000185753 E006 58.856725 0.0004587140 1.854592e-01 3.080774e-01 X 40629937 40630162 226 - 1.746 1.805 0.201
ENSG00000185753 E007 4.618705 0.0035514119 7.575782e-01 8.423522e-01 X 40630163 40630613 451 - 0.770 0.727 -0.172
ENSG00000185753 E008 78.609759 0.0058319324 7.163669e-01 8.120531e-01 X 40630614 40630773 160 - 1.891 1.910 0.062
ENSG00000185753 E009 90.321478 0.0003673636 1.139159e-01 2.112329e-01 X 40636533 40636712 180 - 1.980 1.921 -0.198
ENSG00000185753 E010 70.634256 0.0024177242 1.302600e-02 3.597335e-02 X 40637007 40637156 150 - 1.892 1.769 -0.414
ENSG00000185753 E011 44.628764 0.0069631916 6.539093e-04 2.729983e-03 X 40639009 40639128 120 - 1.732 1.501 -0.788
ENSG00000185753 E012 2.437906 0.0065369618 8.326882e-01 8.951653e-01 X 40639129 40639172 44 - 0.537 0.501 -0.170
ENSG00000185753 E013 6.844729 0.0069926224 6.590964e-01 7.680052e-01 X 40639173 40640320 1148 - 0.908 0.850 -0.222
ENSG00000185753 E014 29.598650 0.0047635775 6.419563e-05 3.519613e-04 X 40647007 40647141 135 - 1.578 1.273 -1.054
ENSG00000185753 E015 3.253876 0.0060523290 5.927137e-03 1.841690e-02 X 40647142 40647304 163 - 0.751 0.272 -2.417
ENSG00000185753 E016 28.235916 0.0007646452 3.592220e-04 1.615821e-03 X 40647305 40647576 272 - 1.543 1.293 -0.864