ENSG00000185730

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330143 ENSG00000185730 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF696 protein_coding protein_coding 6.620555 8.217154 5.74154 0.9458244 0.2177978 -0.5164452 2.2589848 2.5576881 1.9089050 0.16868938 0.19811434 -0.42018667 0.34095417 0.31790000 0.33083333 0.01293333 0.94427484 0.04128634 FALSE  
ENST00000518432 ENSG00000185730 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF696 protein_coding protein_coding 6.620555 8.217154 5.74154 0.9458244 0.2177978 -0.5164452 0.5880705 1.1294651 0.4669674 0.16298674 0.15052296 -1.25639414 0.08829167 0.14126667 0.08360000 -0.05766667 0.45488708 0.04128634 FALSE  
ENST00000520333 ENSG00000185730 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF696 protein_coding protein_coding 6.620555 8.217154 5.74154 0.9458244 0.2177978 -0.5164452 0.4270674 0.6716355 0.1518014 0.07616206 0.07962389 -2.07477634 0.06367917 0.08193333 0.02586667 -0.05606667 0.04128634 0.04128634    
ENST00000521537 ENSG00000185730 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF696 protein_coding protein_coding 6.620555 8.217154 5.74154 0.9458244 0.2177978 -0.5164452 1.0812364 0.9254945 1.2658638 0.24892978 0.31061443 0.44767313 0.16525417 0.10970000 0.21706667 0.10736667 0.23733034 0.04128634    
ENST00000523891 ENSG00000185730 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF696 protein_coding protein_coding 6.620555 8.217154 5.74154 0.9458244 0.2177978 -0.5164452 1.6098296 2.3053736 1.1983572 0.60750352 0.22379195 -0.93819797 0.23834167 0.27310000 0.21116667 -0.06193333 0.68280579 0.04128634 FALSE  
MSTRG.32188.2 ENSG00000185730 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF696 protein_coding   6.620555 8.217154 5.74154 0.9458244 0.2177978 -0.5164452 0.4408270 0.4134143 0.4225029 0.08547876 0.16264178 0.03063991 0.06942500 0.04926667 0.07336667 0.02410000 0.79544464 0.04128634 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185730 E001 16.573600 0.0012946737 8.859021e-02 1.729687e-01 8 143289676 143289818 143 + 1.284 1.170 -0.402
ENSG00000185730 E002 15.930689 0.0012213049 5.597029e-01 6.877824e-01 8 143289855 143289973 119 + 1.213 1.192 -0.074
ENSG00000185730 E003 10.881410 0.0017129872 9.065336e-02 1.761581e-01 8 143290745 143290858 114 + 1.128 0.987 -0.517
ENSG00000185730 E004 1.846606 0.0097710093 2.294838e-01 3.618124e-01 8 143290859 143290909 51 + 0.543 0.358 -0.960
ENSG00000185730 E005 3.205484 0.0082713398 6.367269e-02 1.328158e-01 8 143290910 143291403 494 + 0.745 0.484 -1.155
ENSG00000185730 E006 2.760441 0.0142269310 1.822421e-01 3.040075e-01 8 143291404 143291416 13 + 0.675 0.483 -0.868
ENSG00000185730 E007 3.061396 0.0159446161 6.957677e-02 1.426573e-01 8 143291417 143291421 5 + 0.745 0.483 -1.158
ENSG00000185730 E008 26.641131 0.0007742226 8.359503e-06 5.653535e-05 8 143291422 143291610 189 + 1.569 1.305 -0.912
ENSG00000185730 E009 37.479448 0.0045283290 4.150498e-03 1.356484e-02 8 143291611 143291767 157 + 1.653 1.501 -0.517
ENSG00000185730 E010 9.032541 0.0019540875 1.035878e-01 1.959587e-01 8 143292143 143292284 142 + 1.071 0.925 -0.541
ENSG00000185730 E011 54.687849 0.0004344619 4.869350e-01 6.246589e-01 8 143292972 143293065 94 + 1.672 1.738 0.222
ENSG00000185730 E012 8.137366 0.0279925730 6.332155e-01 7.479551e-01 8 143293066 143293312 247 + 0.948 0.916 -0.121
ENSG00000185730 E013 8.948644 0.0019804298 5.010482e-02 1.093497e-01 8 143295379 143295470 92 + 0.776 1.040 1.003
ENSG00000185730 E014 705.818765 0.0032882710 1.779131e-04 8.692033e-04 8 143295740 143299952 4213 + 2.773 2.847 0.247