ENSG00000185722

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341657 ENSG00000185722 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKFY1 protein_coding protein_coding 20.66036 16.55032 21.43203 0.699072 0.69269 0.372711 17.47564 15.23179 17.37147 0.5990891 0.1471522 0.1895179 0.8497083 0.9206333 0.8119667 -0.1086667 0.0007818768 0.0007818768 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185722 E001 0.8909922 0.0252227847 1.414214e-01 2.499743e-01 17 4160833 4163820 2988 - 0.111 0.391 2.330
ENSG00000185722 E002 34.9283196 0.0006330179 2.071482e-17 9.699357e-16 17 4163821 4163956 136 - 1.166 1.765 2.069
ENSG00000185722 E003 314.4951063 0.0053124343 2.821924e-23 2.573929e-21 17 4163957 4164173 217 - 2.217 2.677 1.534
ENSG00000185722 E004 905.5182337 0.0097315968 2.622944e-11 5.101734e-10 17 4164174 4165073 900 - 2.753 3.101 1.158
ENSG00000185722 E005 300.0970801 0.0031594065 2.064409e-14 6.485838e-13 17 4165074 4165397 324 - 2.301 2.612 1.038
ENSG00000185722 E006 473.5181804 0.0004230010 4.845568e-14 1.441122e-12 17 4165398 4166273 876 - 2.574 2.764 0.633
ENSG00000185722 E007 209.6212833 0.0001987331 5.679533e-02 1.211119e-01 17 4166274 4166525 252 - 2.275 2.376 0.335
ENSG00000185722 E008 65.9381550 0.0005529955 5.936896e-01 7.160401e-01 17 4166526 4166548 23 - 1.792 1.869 0.258
ENSG00000185722 E009 344.2618562 0.0003747966 9.866411e-01 9.957204e-01 17 4166549 4167193 645 - 2.513 2.567 0.177
ENSG00000185722 E010 122.4002418 0.0002545106 1.248613e-02 3.470196e-02 17 4167194 4167334 141 - 2.107 2.080 -0.090
ENSG00000185722 E011 259.3548000 0.0002361079 9.064590e-05 4.780523e-04 17 4167335 4167826 492 - 2.433 2.398 -0.117
ENSG00000185722 E012 55.6136762 0.0004399245 4.271588e-01 5.699954e-01 17 4167827 4167835 9 - 1.749 1.765 0.053
ENSG00000185722 E013 99.2300044 0.0002833943 3.062650e-02 7.318966e-02 17 4167836 4167911 76 - 2.016 1.993 -0.078
ENSG00000185722 E014 2.2404340 0.1733146996 5.932153e-01 7.156538e-01 17 4168151 4168192 42 - 0.557 0.453 -0.507
ENSG00000185722 E015 13.4788721 0.0059748651 1.380456e-03 5.242413e-03 17 4168813 4169197 385 - 1.272 1.005 -0.957
ENSG00000185722 E016 106.7220044 0.0002954570 1.067628e-01 2.007711e-01 17 4169198 4169288 91 - 2.034 2.031 -0.009
ENSG00000185722 E017 112.1350423 0.0009511059 5.679679e-02 1.211123e-01 17 4170715 4170861 147 - 2.061 2.045 -0.055
ENSG00000185722 E018 3.8674333 0.1265983789 1.323463e-01 2.373672e-01 17 4171033 4171170 138 - 0.813 0.503 -1.334
ENSG00000185722 E019 99.9916551 0.0059287275 2.552106e-01 3.920417e-01 17 4172556 4172680 125 - 2.007 1.997 -0.035
ENSG00000185722 E020 101.8910399 0.0042197917 3.853526e-02 8.833858e-02 17 4173354 4173444 91 - 2.033 1.985 -0.160
ENSG00000185722 E021 130.6998411 0.0030256817 1.296261e-01 2.336251e-01 17 4173909 4174056 148 - 2.123 2.112 -0.038
ENSG00000185722 E022 139.2625895 0.0003154510 4.354182e-04 1.910566e-03 17 4177126 4177302 177 - 2.173 2.118 -0.182
ENSG00000185722 E023 1.4361079 0.0144519091 8.618335e-01 9.149236e-01 17 4177882 4178856 975 - 0.389 0.391 0.007
ENSG00000185722 E024 153.5480123 0.0002474233 7.980185e-07 6.767332e-06 17 4178857 4179057 201 - 2.231 2.141 -0.300
ENSG00000185722 E025 2.9173308 0.0053181466 9.469143e-02 1.824182e-01 17 4179058 4179720 663 - 0.679 0.451 -1.048
ENSG00000185722 E026 151.3088613 0.0040847488 9.827966e-05 5.139068e-04 17 4179721 4179877 157 - 2.236 2.122 -0.379
ENSG00000185722 E027 0.2214452 0.0434932860 4.372979e-01   17 4179878 4180436 559 - 0.000 0.135 10.972
ENSG00000185722 E028 2.2801748 0.1406635872 5.829799e-01 7.071842e-01 17 4181026 4181253 228 - 0.557 0.454 -0.498
ENSG00000185722 E029 118.5215433 0.0082279243 3.559190e-02 8.279544e-02 17 4181254 4181372 119 - 2.109 2.043 -0.223
ENSG00000185722 E030 115.7925937 0.0027815873 4.196632e-03 1.369506e-02 17 4182181 4182349 169 - 2.099 2.031 -0.229
ENSG00000185722 E031 9.6625062 0.0018266896 8.311700e-03 2.457168e-02 17 4182350 4182352 3 - 1.130 0.899 -0.850
ENSG00000185722 E032 96.4239720 0.0003447440 8.437433e-09 1.054245e-07 17 4183398 4183525 128 - 2.060 1.902 -0.531
ENSG00000185722 E033 59.2611145 0.0004987529 1.104210e-07 1.113005e-06 17 4183526 4183551 26 - 1.869 1.675 -0.655
ENSG00000185722 E034 95.6888531 0.0042108195 4.367409e-08 4.766086e-07 17 4183812 4183910 99 - 2.078 1.867 -0.708
ENSG00000185722 E035 73.0461837 0.0008524829 1.188945e-07 1.191316e-06 17 4184818 4184863 46 - 1.949 1.773 -0.593
ENSG00000185722 E036 116.7110616 0.0010712022 6.307967e-09 8.079956e-08 17 4184864 4185046 183 - 2.140 1.982 -0.530
ENSG00000185722 E037 0.1472490 0.0433047504 5.439489e-01   17 4186460 4186893 434 - 0.111 0.000 -11.266
ENSG00000185722 E038 0.7760110 0.0156408230 7.416252e-01 8.307127e-01 17 4186894 4188869 1976 - 0.272 0.238 -0.257
ENSG00000185722 E039 72.5075408 0.0048263117 3.701337e-03 1.230065e-02 17 4189382 4189479 98 - 1.912 1.806 -0.357
ENSG00000185722 E040 0.3289534 0.0296985217 9.390938e-01   17 4191187 4191335 149 - 0.111 0.135 0.330
ENSG00000185722 E041 3.0132082 0.0054545367 8.227014e-01 8.882196e-01 17 4194461 4194977 517 - 0.558 0.632 0.330
ENSG00000185722 E042 96.0116117 0.0033973482 1.755027e-04 8.590889e-04 17 4194978 4195177 200 - 2.042 1.921 -0.404
ENSG00000185722 E043 56.4904273 0.0159777247 1.825286e-02 4.768401e-02 17 4195403 4195454 52 - 1.818 1.687 -0.441
ENSG00000185722 E044 45.4501036 0.0059123615 3.748390e-05 2.175750e-04 17 4195455 4195471 17 - 1.758 1.544 -0.730
ENSG00000185722 E045 120.7633300 0.0081011217 1.802896e-07 1.743241e-06 17 4197373 4197577 205 - 2.185 1.951 -0.785
ENSG00000185722 E046 126.1052453 0.0002515691 1.778837e-25 2.042718e-23 17 4206321 4206486 166 - 2.224 1.938 -0.960
ENSG00000185722 E047 129.2424660 0.0074812333 8.317261e-09 1.040602e-07 17 4207933 4208082 150 - 2.221 1.970 -0.842
ENSG00000185722 E048 0.0000000       17 4208083 4208132 50 -      
ENSG00000185722 E049 119.1459814 0.0169577554 4.809685e-05 2.721647e-04 17 4209824 4209947 124 - 2.180 1.943 -0.795
ENSG00000185722 E050 1.9445745 0.0074993202 1.858663e-01 3.085886e-01 17 4216517 4216982 466 - 0.335 0.593 1.328
ENSG00000185722 E051 101.3478690 0.0072342226 1.421891e-06 1.142525e-05 17 4216983 4217118 136 - 2.102 1.890 -0.712
ENSG00000185722 E052 94.7466556 0.0103042925 8.661465e-05 4.592082e-04 17 4235772 4235890 119 - 2.065 1.877 -0.632
ENSG00000185722 E053 81.1639951 0.0193869770 1.182219e-02 3.310833e-02 17 4242256 4242448 193 - 1.979 1.840 -0.466
ENSG00000185722 E054 0.1817044 0.0401703951 4.384431e-01   17 4242449 4242450 2 - 0.000 0.135 11.000
ENSG00000185722 E055 1.0779977 0.0859215720 9.068822e-02 1.762132e-01 17 4263595 4263931 337 - 0.438 0.135 -2.256
ENSG00000185722 E056 27.5950482 0.0141690193 9.724277e-02 1.862688e-01 17 4263932 4263995 64 - 1.502 1.414 -0.303