ENSG00000185697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000522677 ENSG00000185697 HEK293_OSMI2_2hA HEK293_TMG_2hB MYBL1 protein_coding protein_coding 3.458657 1.083547 5.256066 0.1065363 0.2513797 2.26771 2.3143634 0.80467948 3.78782976 0.090365904 0.25296950 2.220871 0.7008000 0.74046667 0.72043333 -0.02003333 8.933689e-01 4.793157e-07 FALSE TRUE
ENST00000523304 ENSG00000185697 HEK293_OSMI2_2hA HEK293_TMG_2hB MYBL1 protein_coding retained_intron 3.458657 1.083547 5.256066 0.1065363 0.2513797 2.26771 0.1530389 0.19975057 0.06640122 0.025901836 0.01303248 -1.457007 0.0839125 0.18493333 0.01263333 -0.17230000 4.793157e-07 4.793157e-07 FALSE FALSE
ENST00000524176 ENSG00000185697 HEK293_OSMI2_2hA HEK293_TMG_2hB MYBL1 protein_coding protein_coding 3.458657 1.083547 5.256066 0.1065363 0.2513797 2.26771 0.7497032 0.05404312 1.11999293 0.007171437 0.13435094 4.141126 0.1535750 0.05206667 0.21490000 0.16283333 7.249172e-03 4.793157e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185697 E001 93.531641 0.0950191465 2.276157e-02 5.725130e-02 8 66562175 66563205 1031 - 1.743 2.169 1.434
ENSG00000185697 E002 19.516752 0.0010034785 1.779824e-01 2.986029e-01 8 66563206 66563264 59 - 1.147 1.341 0.682
ENSG00000185697 E003 93.946863 0.0038010771 1.586055e-01 2.732694e-01 8 66563265 66564671 1407 - 1.820 1.961 0.475
ENSG00000185697 E004 13.435747 0.0012856206 7.118130e-03 2.153238e-02 8 66564672 66564696 25 - 1.077 0.765 -1.179
ENSG00000185697 E005 12.090585 0.0020190000 7.019883e-03 2.127493e-02 8 66564697 66564700 4 - 1.036 0.701 -1.296
ENSG00000185697 E006 26.224693 0.0045024691 3.455188e-02 8.080973e-02 8 66564701 66564825 125 - 1.331 1.190 -0.495
ENSG00000185697 E007 1.924042 0.0072788897 3.650655e-01 5.094008e-01 8 66565133 66565507 375 - 0.412 0.256 -0.975
ENSG00000185697 E008 12.970955 0.0015246299 1.371780e-01 2.441537e-01 8 66566064 66566243 180 - 1.042 0.916 -0.467
ENSG00000185697 E009 27.441265 0.0007525607 2.779846e-01 4.176194e-01 8 66566684 66566788 105 - 1.333 1.308 -0.090
ENSG00000185697 E010 30.526059 0.0006405110 4.990677e-01 6.354137e-01 8 66566876 66566992 117 - 1.371 1.386 0.051
ENSG00000185697 E011 21.889128 0.0009034693 8.144043e-01 8.824033e-01 8 66572482 66572596 115 - 1.225 1.272 0.164
ENSG00000185697 E012 24.430370 0.0008017634 1.190663e-01 2.186112e-01 8 66573364 66573506 143 - 1.292 1.212 -0.281
ENSG00000185697 E013 22.076821 0.0010206543 1.745166e-03 6.424851e-03 8 66576007 66576133 127 - 1.274 0.993 -1.007
ENSG00000185697 E014 33.380800 0.0006455078 1.925684e-06 1.503152e-05 8 66576134 66576375 242 - 1.455 1.059 -1.396
ENSG00000185697 E015 33.024440 0.0138860074 1.742910e-02 4.588826e-02 8 66580133 66580366 234 - 1.430 1.254 -0.614
ENSG00000185697 E016 21.351167 0.0009165196 3.039353e-02 7.273371e-02 8 66592440 66592544 105 - 1.249 1.089 -0.571
ENSG00000185697 E017 17.986788 0.0009671895 9.830496e-02 1.879385e-01 8 66593120 66593194 75 - 1.175 1.059 -0.417
ENSG00000185697 E018 31.733929 0.0006704318 3.586410e-01 5.030315e-01 8 66595583 66595757 175 - 1.390 1.386 -0.015
ENSG00000185697 E019 34.627954 0.0005914463 2.780493e-01 4.176726e-01 8 66597330 66597509 180 - 1.428 1.414 -0.050
ENSG00000185697 E020 17.432475 0.0023871528 7.936055e-02 1.585044e-01 8 66597510 66597524 15 - 1.163 1.027 -0.491
ENSG00000185697 E021 16.467183 0.0016624344 1.233922e-01 2.247848e-01 8 66597525 66597550 26 - 1.139 1.027 -0.404
ENSG00000185697 E022 22.815616 0.0008439989 1.342021e-01 2.399979e-01 8 66599050 66599142 93 - 1.267 1.190 -0.275
ENSG00000185697 E023 19.650407 0.0071334854 3.538894e-01 4.981742e-01 8 66601698 66601769 72 - 1.201 1.166 -0.123
ENSG00000185697 E024 28.037071 0.0013109918 4.378050e-01 5.796937e-01 8 66602418 66602523 106 - 1.339 1.341 0.008
ENSG00000185697 E025 3.721361 0.0045485650 1.759231e-09 2.491075e-08 8 66612145 66612513 369 - 0.220 1.142 4.290
ENSG00000185697 E026 4.848095 0.0039832528 1.341469e-10 2.319405e-09 8 66612514 66612818 305 - 0.312 1.233 3.934
ENSG00000185697 E027 37.872140 0.0006298480 1.045599e-02 2.987806e-02 8 66612819 66614247 1429 - 1.415 1.655 0.822