ENSG00000185684

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389560 ENSG00000185684 HEK293_OSMI2_2hA HEK293_TMG_2hB EP400P1 transcribed_unprocessed_pseudogene processed_transcript 10.01058 13.0602 8.473528 1.028034 0.1486152 -0.6235444 0.3044703 0.9786881 0.04001497 0.4050066 0.04001497 -4.3050836 0.02659583 0.07210000 0.004633333 -0.06746667 4.135477e-02 3.221591e-08 FALSE TRUE
ENST00000392352 ENSG00000185684 HEK293_OSMI2_2hA HEK293_TMG_2hB EP400P1 transcribed_unprocessed_pseudogene processed_transcript 10.01058 13.0602 8.473528 1.028034 0.1486152 -0.6235444 1.1881888 1.6318016 0.59771133 0.2514289 0.10459183 -1.4338217 0.11711250 0.12356667 0.070566667 -0.05300000 1.016790e-01 3.221591e-08 FALSE TRUE
ENST00000537558 ENSG00000185684 HEK293_OSMI2_2hA HEK293_TMG_2hB EP400P1 transcribed_unprocessed_pseudogene processed_transcript 10.01058 13.0602 8.473528 1.028034 0.1486152 -0.6235444 0.8929484 0.6273443 1.17491382 0.3435876 0.26131287 0.8946374 0.09797500 0.05210000 0.138033333 0.08593333 4.785544e-01 3.221591e-08   FALSE
ENST00000613241 ENSG00000185684 HEK293_OSMI2_2hA HEK293_TMG_2hB EP400P1 transcribed_unprocessed_pseudogene processed_transcript 10.01058 13.0602 8.473528 1.028034 0.1486152 -0.6235444 0.5596137 1.6925767 0.77395819 0.0859183 0.39781495 -1.1188712 0.05376667 0.13070000 0.089766667 -0.04093333 7.413067e-01 3.221591e-08   FALSE
ENST00000690966 ENSG00000185684 HEK293_OSMI2_2hA HEK293_TMG_2hB EP400P1 transcribed_unprocessed_pseudogene processed_transcript 10.01058 13.0602 8.473528 1.028034 0.1486152 -0.6235444 1.1314210 2.4056661 0.57799043 0.4120967 0.29551676 -2.0385565 0.10279583 0.18976667 0.069100000 -0.12066667 4.634429e-01 3.221591e-08 FALSE TRUE
MSTRG.8334.15 ENSG00000185684 HEK293_OSMI2_2hA HEK293_TMG_2hB EP400P1 transcribed_unprocessed_pseudogene   10.01058 13.0602 8.473528 1.028034 0.1486152 -0.6235444 0.8288842 1.2422149 0.18995357 0.2265108 0.18995357 -2.6467453 0.07843333 0.09400000 0.022033333 -0.07196667 1.440013e-01 3.221591e-08 TRUE TRUE
MSTRG.8334.16 ENSG00000185684 HEK293_OSMI2_2hA HEK293_TMG_2hB EP400P1 transcribed_unprocessed_pseudogene   10.01058 13.0602 8.473528 1.028034 0.1486152 -0.6235444 1.7530623 0.9491059 2.22530542 0.1881722 0.16211381 1.2207100 0.19167917 0.07176667 0.262533333 0.19076667 3.221591e-08 3.221591e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185684 E001 0.5880631 0.2322855700 7.866224e-01 8.633473e-01 12 132084275 132084276 2 + 0.141 0.196 0.577
ENSG00000185684 E002 0.5880631 0.2322855700 7.866224e-01 8.633473e-01 12 132084277 132084282 6 + 0.140 0.196 0.582
ENSG00000185684 E003 0.5880631 0.2322855700 7.866224e-01 8.633473e-01 12 132084283 132084284 2 + 0.140 0.196 0.582
ENSG00000185684 E004 0.7332358 0.4296225496 8.391682e-01 8.994865e-01 12 132084285 132084289 5 + 0.246 0.199 -0.384
ENSG00000185684 E005 0.7332358 0.4296225496 8.391682e-01 8.994865e-01 12 132084290 132084290 1 + 0.246 0.199 -0.384
ENSG00000185684 E006 1.1363854 0.2545064067 6.858710e-01 7.884909e-01 12 132084291 132084294 4 + 0.246 0.334 0.606
ENSG00000185684 E007 2.5046267 0.0060398549 4.306028e-01 5.732196e-01 12 132084295 132084298 4 + 0.608 0.469 -0.654
ENSG00000185684 E008 4.0213768 0.0041180622 3.805826e-02 8.745889e-02 12 132084299 132084301 3 + 0.852 0.544 -1.292
ENSG00000185684 E009 5.0500661 0.0033318931 1.942393e-01 3.190637e-01 12 132084302 132084302 1 + 0.875 0.689 -0.743
ENSG00000185684 E010 8.3609034 0.0020537386 6.792391e-01 7.834916e-01 12 132084303 132084312 10 + 0.991 0.929 -0.231
ENSG00000185684 E011 9.4627593 0.0020806797 7.018605e-01 8.008383e-01 12 132084313 132084314 2 + 1.039 0.982 -0.208
ENSG00000185684 E012 11.2299845 0.0016357975 5.116466e-01 6.466089e-01 12 132084315 132084319 5 + 1.121 1.041 -0.292
ENSG00000185684 E013 12.5960478 0.0014738969 5.176730e-01 6.520146e-01 12 132084320 132084324 5 + 1.169 1.092 -0.275
ENSG00000185684 E014 15.2416800 0.0012003914 4.813770e-01 6.196057e-01 12 132084325 132084330 6 + 1.241 1.164 -0.274
ENSG00000185684 E015 17.7441272 0.0010746567 7.918875e-01 8.668911e-01 12 132084331 132084343 13 + 1.278 1.240 -0.134
ENSG00000185684 E016 27.7323075 0.0007880578 5.265753e-01 6.597812e-01 12 132084344 132084399 56 + 1.478 1.419 -0.202
ENSG00000185684 E017 23.7482790 0.0031241008 8.539209e-01 9.096179e-01 12 132084480 132084962 483 + 1.386 1.356 -0.103
ENSG00000185684 E018 10.8126967 0.0328457829 9.268839e-01 9.579828e-01 12 132084963 132084963 1 + 1.039 1.049 0.037
ENSG00000185684 E019 44.3811709 0.0005094883 8.117910e-01 8.805790e-01 12 132084964 132085065 102 + 1.656 1.627 -0.101
ENSG00000185684 E020 52.9254508 0.0004626319 2.655764e-02 6.506900e-02 12 132085066 132085225 160 + 1.653 1.745 0.315
ENSG00000185684 E021 33.2386330 0.0006645684 2.430697e-03 8.554334e-03 12 132085226 132085256 31 + 1.392 1.569 0.607
ENSG00000185684 E022 39.4406965 0.0005801446 1.211561e-05 7.896469e-05 12 132085257 132085316 60 + 1.425 1.667 0.829
ENSG00000185684 E023 3.5355062 0.0045418185 9.859050e-01 9.951985e-01 12 132085405 132085408 4 + 0.647 0.636 -0.047
ENSG00000185684 E024 13.1148051 0.0191350872 3.354934e-01 4.792759e-01 12 132085409 132085797 389 + 1.082 1.177 0.341
ENSG00000185684 E025 3.8956901 0.0041733731 1.426949e-02 3.883902e-02 12 132088420 132088520 101 + 0.403 0.778 1.708
ENSG00000185684 E026 1.5446326 0.0311970513 5.624944e-01 6.900713e-01 12 132090651 132090848 198 + 0.332 0.426 0.540
ENSG00000185684 E027 26.9414490 0.0017850583 4.818074e-08 5.214932e-07 12 132090849 132090898 50 + 1.146 1.545 1.392
ENSG00000185684 E028 26.3160705 0.0007868782 5.871025e-08 6.233876e-07 12 132090899 132090943 45 + 1.134 1.528 1.376
ENSG00000185684 E029 6.9192763 0.0025332263 9.875477e-04 3.916104e-03 12 132091395 132091468 74 + 0.565 0.995 1.731
ENSG00000185684 E030 6.8732945 0.0024476972 9.874644e-03 2.845705e-02 12 132091469 132091516 48 + 0.647 0.970 1.275
ENSG00000185684 E031 20.9677738 0.0009688125 2.491046e-08 2.850110e-07 12 132103997 132104020 24 + 0.973 1.441 1.664
ENSG00000185684 E032 38.7428405 0.0006137305 3.248493e-07 2.983696e-06 12 132104021 132104170 150 + 1.372 1.667 1.013
ENSG00000185684 E033 4.6706319 0.0053745653 5.320974e-01 6.644711e-01 12 132104171 132104374 204 + 0.683 0.757 0.305
ENSG00000185684 E034 3.3744269 0.0444852770 8.961914e-01 9.376682e-01 12 132104375 132104377 3 + 0.647 0.610 -0.162
ENSG00000185684 E035 21.3716646 0.0047261407 9.571767e-03 2.771169e-02 12 132104378 132104566 189 + 1.201 1.400 0.696
ENSG00000185684 E036 29.2030746 0.0007386409 1.810759e-06 1.422352e-05 12 132104567 132104949 383 + 1.241 1.559 1.100
ENSG00000185684 E037 99.7449355 0.0014933516 4.690150e-13 1.213017e-11 12 132104950 132105304 355 + 1.793 2.074 0.944
ENSG00000185684 E038 71.7489833 0.0008414696 1.183321e-08 1.439336e-07 12 132108572 132108682 111 + 1.681 1.922 0.814
ENSG00000185684 E039 39.7502914 0.0063152272 2.555535e-13 6.859429e-12 12 132108683 132108899 217 + 1.191 1.733 1.871
ENSG00000185684 E040 7.3720330 0.0023824549 1.089827e-02 3.091897e-02 12 132109768 132109832 65 + 1.068 0.757 -1.181
ENSG00000185684 E041 16.5767002 0.0011664089 4.874454e-02 1.069341e-01 12 132114458 132114545 88 + 1.327 1.147 -0.635
ENSG00000185684 E042 1.5530506 0.1257519265 7.735316e-02 1.552348e-01 12 132115198 132115291 94 + 0.140 0.505 2.528
ENSG00000185684 E043 1.9207283 0.0076137725 9.260318e-01 9.574259e-01 12 132118146 132118830 685 + 0.464 0.468 0.021
ENSG00000185684 E044 0.8469850 0.0136968632 2.825085e-01 4.225191e-01 12 132118831 132119196 366 + 0.141 0.324 1.537
ENSG00000185684 E045 27.4219259 0.0008703587 2.168537e-04 1.036045e-03 12 132120420 132120601 182 + 1.576 1.316 -0.897
ENSG00000185684 E046 22.4412055 0.0009151107 3.059514e-06 2.284920e-05 12 132121440 132121579 140 + 1.534 1.180 -1.232
ENSG00000185684 E047 0.0000000       12 132121690 132121765 76 +      
ENSG00000185684 E048 9.7335754 0.0018275291 5.003691e-02 1.092395e-01 12 132121925 132121980 56 + 1.134 0.914 -0.806
ENSG00000185684 E049 5.5263478 0.0030571584 5.171953e-05 2.902885e-04 12 132121981 132123580 1600 + 1.054 0.508 -2.217
ENSG00000185684 E050 23.2383591 0.0030791885 1.121033e-01 2.086252e-01 12 132125194 132125396 203 + 1.449 1.316 -0.463
ENSG00000185684 E051 0.8502072 0.0142953647 8.916315e-01 9.347850e-01 12 132125397 132125408 12 + 0.247 0.263 0.123
ENSG00000185684 E052 28.7250846 0.0006682627 1.148821e-05 7.529253e-05 12 132125854 132126047 194 + 1.618 1.321 -1.020
ENSG00000185684 E053 7.9337953 0.0021314504 1.645689e-01 2.811203e-01 12 132126048 132126340 293 + 1.039 0.868 -0.640
ENSG00000185684 E054 12.5202754 0.0152684467 9.282554e-06 6.216161e-05 12 132126376 132126434 59 + 1.358 0.853 -1.831
ENSG00000185684 E055 37.3833427 0.0006051939 2.283913e-21 1.708174e-19 12 132126435 132127080 646 + 1.829 1.260 -1.951
ENSG00000185684 E056 11.7764896 0.0095890833 1.901135e-04 9.216988e-04 12 132127081 132127197 117 + 1.295 0.885 -1.485
ENSG00000185684 E057 48.0009996 0.0117602421 2.214334e-08 2.560887e-07 12 132127198 132128097 900 + 1.883 1.467 -1.412
ENSG00000185684 E058 52.4970615 0.0097325532 1.553103e-06 1.237095e-05 12 132128098 132128759 662 + 1.889 1.555 -1.134
ENSG00000185684 E059 258.6510480 0.0028505874 5.010268e-04 2.163867e-03 12 132128760 132131639 2880 + 2.464 2.351 -0.377