ENSG00000185630

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367897 ENSG00000185630 HEK293_OSMI2_2hA HEK293_TMG_2hB PBX1 protein_coding protein_coding 7.092277 7.471576 8.398716 0.6503252 0.5070073 0.1685434 0.5744844 0.000000 1.603357 0.0000000 0.1947668 7.333921802 0.06982917 0.0000000 0.1896333 0.18963333 3.229843e-22 3.229843e-22 FALSE TRUE
ENST00000420696 ENSG00000185630 HEK293_OSMI2_2hA HEK293_TMG_2hB PBX1 protein_coding protein_coding 7.092277 7.471576 8.398716 0.6503252 0.5070073 0.1685434 2.0352160 1.393939 2.575950 0.2612370 0.2601100 0.881214249 0.29348333 0.1908000 0.3103333 0.11953333 2.771755e-01 3.229843e-22 FALSE TRUE
ENST00000612123 ENSG00000185630 HEK293_OSMI2_2hA HEK293_TMG_2hB PBX1 protein_coding protein_coding 7.092277 7.471576 8.398716 0.6503252 0.5070073 0.1685434 3.1568595 3.476274 3.496334 0.3407459 0.3149851 0.008277703 0.45184167 0.4644333 0.4158667 -0.04856667 5.752379e-01 3.229843e-22 FALSE TRUE
ENST00000627490 ENSG00000185630 HEK293_OSMI2_2hA HEK293_TMG_2hB PBX1 protein_coding protein_coding 7.092277 7.471576 8.398716 0.6503252 0.5070073 0.1685434 0.6496980 2.233131 0.000000 0.6205001 0.0000000 -7.809370338 0.09335000 0.2938333 0.0000000 -0.29383333 5.118709e-12 3.229843e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185630 E001 0.0000000       1 164555584 164555719 136 +      
ENSG00000185630 E002 7.2129690 0.0393509353 2.385509e-01 3.724534e-01 1 164559184 164559199 16 + 0.974 0.845 -0.490
ENSG00000185630 E003 11.6967049 0.0546302455 1.455668e-01 2.556339e-01 1 164559200 164559355 156 + 1.180 1.010 -0.614
ENSG00000185630 E004 6.3699572 0.0027805371 6.635430e-01 7.715637e-01 1 164559356 164559406 51 + 0.827 0.923 0.368
ENSG00000185630 E005 11.4357155 0.0019178965 7.766624e-01 8.561707e-01 1 164559407 164559529 123 + 1.062 1.135 0.265
ENSG00000185630 E006 15.6872811 0.0015245895 9.972487e-01 1.000000e+00 1 164559530 164559721 192 + 1.205 1.252 0.165
ENSG00000185630 E007 15.0793836 0.0057025028 7.047634e-01 8.032445e-01 1 164559722 164559743 22 + 1.171 1.251 0.283
ENSG00000185630 E008 23.7952291 0.0111984352 8.540904e-01 9.097309e-01 1 164559744 164559822 79 + 1.383 1.408 0.088
ENSG00000185630 E009 39.1083086 0.0158102809 4.694012e-01 6.086409e-01 1 164559823 164560012 190 + 1.616 1.591 -0.082
ENSG00000185630 E010 18.6699913 0.0151028243 1.829944e-01 3.049455e-01 1 164560013 164560013 1 + 1.338 1.245 -0.325
ENSG00000185630 E011 0.0000000       1 164560014 164560145 132 +      
ENSG00000185630 E012 0.1482932 0.0406165356 4.654886e-01   1 164560146 164560450 305 + 0.000 0.131 10.993
ENSG00000185630 E013 0.0000000       1 164562805 164562930 126 +      
ENSG00000185630 E014 29.2524572 0.0014160750 2.605244e-02 6.405487e-02 1 164563238 164563311 74 + 1.529 1.432 -0.334
ENSG00000185630 E015 0.0000000       1 164563928 164564015 88 +      
ENSG00000185630 E016 0.0000000       1 164576784 164577004 221 +      
ENSG00000185630 E017 0.2944980 0.4147822869 3.209155e-01   1 164590350 164590434 85 + 0.205 0.000 -11.301
ENSG00000185630 E018 0.2214452 0.0480311861 4.609934e-01   1 164605193 164605419 227 + 0.000 0.131 10.939
ENSG00000185630 E019 1.6220525 0.0113558682 9.491459e-01 9.721242e-01 1 164625929 164626005 77 + 0.399 0.441 0.225
ENSG00000185630 E020 0.7437457 0.0153787590 1.847974e-01 3.072181e-01 1 164626006 164626035 30 + 0.343 0.131 -1.777
ENSG00000185630 E021 1.0435544 0.0185168191 2.773468e-01 4.169048e-01 1 164626036 164626096 61 + 0.399 0.231 -1.101
ENSG00000185630 E022 0.0000000       1 164630981 164631116 136 +      
ENSG00000185630 E023 0.2965864 0.0736843982 2.040013e-01   1 164641029 164642193 1165 + 0.000 0.230 11.745
ENSG00000185630 E024 0.0000000       1 164642693 164642829 137 +      
ENSG00000185630 E025 0.0000000       1 164651896 164652139 244 +      
ENSG00000185630 E026 0.0000000       1 164657113 164657372 260 +      
ENSG00000185630 E027 0.0000000       1 164674490 164674816 327 +      
ENSG00000185630 E028 0.0000000       1 164682130 164682309 180 +      
ENSG00000185630 E029 0.7029582 0.0172671820 2.930376e-01 4.340721e-01 1 164682310 164684965 2656 + 0.114 0.313 1.810
ENSG00000185630 E030 0.0000000       1 164772912 164773022 111 +      
ENSG00000185630 E031 0.0000000       1 164787643 164787753 111 +      
ENSG00000185630 E032 0.1482932 0.0406165356 4.654886e-01   1 164792492 164792493 2 + 0.000 0.131 10.993
ENSG00000185630 E033 61.2351802 0.0021390798 3.314984e-01 4.751310e-01 1 164792494 164792738 245 + 1.795 1.794 -0.005
ENSG00000185630 E034 60.0521245 0.0055270339 2.524621e-01 3.888155e-01 1 164799699 164799889 191 + 1.798 1.780 -0.061
ENSG00000185630 E035 64.9267152 0.0004394691 1.300479e-01 2.342272e-01 1 164807542 164807677 136 + 1.833 1.817 -0.053
ENSG00000185630 E036 79.4358977 0.0003543051 5.216248e-01 6.555067e-01 1 164811990 164812149 160 + 1.870 1.944 0.248
ENSG00000185630 E037 2.3690336 0.0063011606 2.281544e-01 3.602291e-01 1 164812728 164820071 7344 + 0.603 0.441 -0.775
ENSG00000185630 E038 17.7100666 0.0010689946 5.508154e-01 6.803740e-01 1 164820072 164820184 113 + 1.221 1.316 0.332
ENSG00000185630 E039 61.9083242 0.0004019692 5.067857e-01 6.424372e-01 1 164821537 164821626 90 + 1.793 1.813 0.067
ENSG00000185630 E040 0.0000000       1 164831471 164831483 13 +      
ENSG00000185630 E041 471.0837290 0.0025503943 3.470711e-15 1.223058e-13 1 164846584 164849339 2756 + 2.736 2.607 -0.432
ENSG00000185630 E042 502.7941293 0.0085017608 4.651704e-10 7.321795e-09 1 164849340 164851831 2492 + 2.553 2.812 0.862
ENSG00000185630 E043 0.0000000       1 164899188 164899296 109 +