ENSG00000185619

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000362003 ENSG00000185619 HEK293_OSMI2_2hA HEK293_TMG_2hB PCGF3 protein_coding protein_coding 21.66693 24.1345 23.71099 1.745229 0.7791946 -0.02553084 6.7236825 5.6586135 8.756573 0.7848334 0.1445003 0.6290170 0.309700000 0.23240000 0.37006667 0.13766667 6.547244e-04 4.488831e-06 FALSE TRUE
ENST00000400151 ENSG00000185619 HEK293_OSMI2_2hA HEK293_TMG_2hB PCGF3 protein_coding protein_coding 21.66693 24.1345 23.71099 1.745229 0.7791946 -0.02553084 6.0905395 10.5908068 3.599300 0.7175279 0.3524857 -1.5543833 0.284645833 0.44600000 0.15116667 -0.29483333 4.488831e-06 4.488831e-06 FALSE TRUE
ENST00000620529 ENSG00000185619 HEK293_OSMI2_2hA HEK293_TMG_2hB PCGF3 protein_coding protein_coding 21.66693 24.1345 23.71099 1.745229 0.7791946 -0.02553084 0.1900082 1.5200658 0.000000 1.2992386 0.0000000 -7.2574499 0.007033333 0.05626667 0.00000000 -0.05626667 2.025266e-01 4.488831e-06 FALSE FALSE
MSTRG.24416.4 ENSG00000185619 HEK293_OSMI2_2hA HEK293_TMG_2hB PCGF3 protein_coding   21.66693 24.1345 23.71099 1.745229 0.7791946 -0.02553084 1.4543135 1.8565626 1.024240 0.6800436 0.5450098 -0.8518131 0.067041667 0.07970000 0.04186667 -0.03783333 7.186857e-01 4.488831e-06 FALSE TRUE
MSTRG.24416.6 ENSG00000185619 HEK293_OSMI2_2hA HEK293_TMG_2hB PCGF3 protein_coding   21.66693 24.1345 23.71099 1.745229 0.7791946 -0.02553084 1.2529105 0.2687349 2.713069 0.2687349 0.8671945 3.2882677 0.055254167 0.01213333 0.11493333 0.10280000 6.070931e-02 4.488831e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185619 E001 0.3686942 0.0327376340 9.565352e-01 9.767406e-01 4 705748 705764 17 + 0.113 0.133 0.270
ENSG00000185619 E002 0.8793520 0.2467865171 5.968347e-01 7.187116e-01 4 705765 705779 15 + 0.202 0.321 0.880
ENSG00000185619 E003 1.0610564 0.3788265020 4.592745e-01 5.994858e-01 4 705780 705781 2 + 0.202 0.392 1.307
ENSG00000185619 E004 1.0610564 0.3788265020 4.592745e-01 5.994858e-01 4 705782 705783 2 + 0.202 0.392 1.307
ENSG00000185619 E005 1.8371666 0.2648234334 2.930165e-01 4.340530e-01 4 705784 705791 8 + 0.277 0.558 1.550
ENSG00000185619 E006 3.7506072 0.0700217584 1.390854e-01 2.468135e-01 4 705792 705807 16 + 0.488 0.786 1.297
ENSG00000185619 E007 5.5876641 0.0874665680 6.839496e-01 7.870222e-01 4 705808 705831 24 + 0.759 0.857 0.385
ENSG00000185619 E008 43.5340028 0.0050733753 4.684645e-01 6.078753e-01 4 705832 705874 43 + 1.649 1.646 -0.012
ENSG00000185619 E009 80.2727937 0.0159805917 3.667993e-01 5.111341e-01 4 705875 705942 68 + 1.856 1.956 0.336
ENSG00000185619 E010 74.2631492 0.0150201314 3.789489e-01 5.232374e-01 4 705943 705970 28 + 1.823 1.921 0.332
ENSG00000185619 E011 0.3299976 0.0274424043 1.805960e-01   4 725107 725229 123 + 0.000 0.234 11.470
ENSG00000185619 E012 86.9768409 0.0087744737 3.536828e-01 4.979425e-01 4 730630 730668 39 + 1.896 1.988 0.311
ENSG00000185619 E013 1.3628410 0.1045306135 3.901974e-01 5.342000e-01 4 730952 730969 18 + 0.276 0.490 1.232
ENSG00000185619 E014 172.2475739 0.0020412066 1.504442e-05 9.600892e-05 4 730970 731110 141 + 2.135 2.325 0.634
ENSG00000185619 E015 3.7891175 0.0042545612 4.286662e-01 5.713951e-01 4 731111 731345 235 + 0.598 0.751 0.645
ENSG00000185619 E016 12.2541800 0.0102648431 2.437339e-01 3.785739e-01 4 732400 732443 44 + 1.033 1.194 0.581
ENSG00000185619 E017 15.9916638 0.0125957807 1.279651e-01 2.313297e-01 4 732444 732498 55 + 1.120 1.309 0.671
ENSG00000185619 E018 81.8720795 0.0009192321 2.624834e-04 1.226608e-03 4 733672 733674 3 + 1.810 2.005 0.659
ENSG00000185619 E019 196.7217722 0.0008794393 1.736384e-06 1.369210e-05 4 733675 733789 115 + 2.198 2.377 0.600
ENSG00000185619 E020 76.8582159 0.0224503055 1.225106e-08 1.486535e-07 4 733790 733883 94 + 1.550 2.076 1.779
ENSG00000185619 E021 230.2420683 0.0137200429 3.423295e-12 7.700462e-11 4 733884 734789 906 + 2.077 2.533 1.524
ENSG00000185619 E022 22.8198890 0.0008359617 1.970951e-05 1.224353e-04 4 734790 734930 141 + 1.495 1.232 -0.915
ENSG00000185619 E023 124.4905103 0.0053839386 1.520549e-04 7.560522e-04 4 734931 735027 97 + 2.162 2.027 -0.454
ENSG00000185619 E024 111.6361314 0.0062056509 1.163382e-04 5.970775e-04 4 737466 737521 56 + 2.122 1.973 -0.501
ENSG00000185619 E025 0.2955422 0.0286103296 9.674900e-01   4 737522 737540 19 + 0.113 0.132 0.264
ENSG00000185619 E026 133.5156564 0.0003113872 2.978796e-09 4.043014e-08 4 743474 743584 111 + 2.194 2.060 -0.451
ENSG00000185619 E027 0.2214452 0.0434421341 4.484452e-01   4 743865 743952 88 + 0.000 0.133 10.278
ENSG00000185619 E028 111.9278684 0.0002594125 1.268624e-05 8.231567e-05 4 744600 744688 89 + 2.103 2.007 -0.323
ENSG00000185619 E029 127.7638172 0.0002457661 8.387086e-05 4.463727e-04 4 761279 761416 138 + 2.149 2.076 -0.247
ENSG00000185619 E030 12.0557985 0.0017743521 1.280178e-02 3.544922e-02 4 761730 762369 640 + 0.955 1.241 1.034
ENSG00000185619 E031 110.7438598 0.0006861400 1.800214e-02 4.713758e-02 4 764984 765064 81 + 2.072 2.038 -0.111
ENSG00000185619 E032 54.0614578 0.0004683213 9.067448e-01 9.447758e-01 4 766032 766034 3 + 1.719 1.772 0.180
ENSG00000185619 E033 215.2716740 0.0009618508 1.085396e-01 2.033919e-01 4 766035 766405 371 + 2.338 2.343 0.017
ENSG00000185619 E034 89.9846711 0.0056201481 3.986607e-03 1.310517e-02 4 766406 766673 268 + 2.012 1.910 -0.342
ENSG00000185619 E035 420.2061703 0.0002969931 1.078394e-35 2.745947e-33 4 766674 768188 1515 + 2.706 2.535 -0.572
ENSG00000185619 E036 508.8957848 0.0377752010 8.147383e-01 8.826244e-01 4 768189 770640 2452 + 2.658 2.753 0.314