ENSG00000185567

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333244 ENSG00000185567 HEK293_OSMI2_2hA HEK293_TMG_2hB AHNAK2 protein_coding protein_coding 1.493515 2.096351 0.9986981 0.09238044 0.05819221 -1.062251 0.39651320 0.2795461 0.5392981 0.11290009 0.01872916 0.9237962 0.3364125 0.13500000 0.5455667 0.41056667 0.001639722 0.001639722 FALSE TRUE
ENST00000555122 ENSG00000185567 HEK293_OSMI2_2hA HEK293_TMG_2hB AHNAK2 protein_coding retained_intron 1.493515 2.096351 0.9986981 0.09238044 0.05819221 -1.062251 0.08309127 0.1145482 0.0000000 0.06650051 0.00000000 -3.6386318 0.0427250 0.05246667 0.0000000 -0.05246667 0.280012195 0.001639722 FALSE TRUE
ENST00000557457 ENSG00000185567 HEK293_OSMI2_2hA HEK293_TMG_2hB AHNAK2 protein_coding protein_coding 1.493515 2.096351 0.9986981 0.09238044 0.05819221 -1.062251 0.96317026 1.6720608 0.4039949 0.10876009 0.08494430 -2.0225451 0.5712792 0.79810000 0.3969667 -0.40113333 0.002695846 0.001639722 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185567 E001 0.0000000       14 104937244 104937252 9 -      
ENSG00000185567 E002 184.6643601 0.036401577 5.240683e-08 5.626703e-07 14 104937253 104940559 3307 - 1.958 2.431 1.582
ENSG00000185567 E003 13.6477321 0.001824884 5.985824e-02 1.263745e-01 14 104940560 104940873 314 - 0.946 1.277 1.196
ENSG00000185567 E004 8.0482556 0.058402267 2.195570e-01 3.498593e-01 14 104940874 104940978 105 - 0.732 1.087 1.355
ENSG00000185567 E005 35.1086672 0.006652271 6.110023e-02 1.284840e-01 14 104940979 104942323 1345 - 1.526 1.566 0.137
ENSG00000185567 E006 5.0091397 0.013653428 2.617264e-01 3.994078e-01 14 104942324 104942469 146 - 0.779 0.760 -0.078
ENSG00000185567 E007 82.5824430 0.003038917 8.782954e-08 9.012590e-07 14 104942470 104949894 7425 - 1.939 1.892 -0.157
ENSG00000185567 E008 18.7535598 0.034305830 5.764544e-06 4.046673e-05 14 104949895 104953536 3642 - 1.450 1.077 -1.314
ENSG00000185567 E009 6.1309244 0.120825832 7.404935e-03 2.227123e-02 14 104953537 104953880 344 - 1.016 0.639 -1.483
ENSG00000185567 E010 8.3976095 0.002161456 1.434081e-07 1.413760e-06 14 104953881 104954799 919 - 1.151 0.704 -1.697
ENSG00000185567 E011 0.0000000       14 104954800 104954956 157 -      
ENSG00000185567 E012 3.2839658 0.004734524 2.008096e-06 1.561498e-05 14 104954957 104955141 185 - 0.861 0.224 -3.212
ENSG00000185567 E013 0.0000000       14 104955142 104955402 261 -      
ENSG00000185567 E014 2.3552934 0.006646200 1.412140e-05 9.059453e-05 14 104955483 104955633 151 - 0.756 0.126 -3.797
ENSG00000185567 E015 1.9468438 0.007672315 1.593331e-04 7.888458e-04 14 104956588 104956689 102 - 0.677 0.126 -3.475
ENSG00000185567 E016 1.6931438 0.008785224 8.056812e-03 2.392381e-02 14 104957410 104957508 99 - 0.582 0.224 -2.060
ENSG00000185567 E017 1.1823723 0.010755164 4.426979e-04 1.938654e-03 14 104957614 104957672 59 - 0.545 0.000 -15.577
ENSG00000185567 E018 0.0000000       14 104970456 104970481 26 -      
ENSG00000185567 E019 0.7665478 0.017738183 9.028912e-02 1.755772e-01 14 104978183 104978374 192 - 0.353 0.126 -1.889