ENSG00000185504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327787 ENSG00000185504 HEK293_OSMI2_2hA HEK293_TMG_2hB FAAP100 protein_coding protein_coding 28.14261 50.74924 18.33569 3.937349 0.6826112 -1.468229 10.830925 23.948540 5.548310 1.2125502 0.5896672 -2.1078217 0.34919167 0.47403333 0.3011000 -0.17293333 4.442273e-05 4.442273e-05 FALSE TRUE
ENST00000425898 ENSG00000185504 HEK293_OSMI2_2hA HEK293_TMG_2hB FAAP100 protein_coding protein_coding 28.14261 50.74924 18.33569 3.937349 0.6826112 -1.468229 5.563054 8.834083 3.617037 0.7949313 0.3014586 -1.2859210 0.20822083 0.17466667 0.1972000 0.02253333 6.965971e-01 4.442273e-05 FALSE TRUE
ENST00000443656 ENSG00000185504 HEK293_OSMI2_2hA HEK293_TMG_2hB FAAP100 protein_coding nonsense_mediated_decay 28.14261 50.74924 18.33569 3.937349 0.6826112 -1.468229 7.936585 13.186066 5.615421 2.5178985 0.6526114 -1.2300749 0.28253333 0.25506667 0.3096667 0.05460000 7.215355e-01 4.442273e-05 FALSE TRUE
ENST00000541246 ENSG00000185504 HEK293_OSMI2_2hA HEK293_TMG_2hB FAAP100 protein_coding protein_coding 28.14261 50.74924 18.33569 3.937349 0.6826112 -1.468229 1.531168 1.106115 1.873808 0.1759719 0.5892476 0.7551666 0.07389583 0.02166667 0.1003000 0.07863333 4.224256e-03 4.442273e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185504 E001 2.5056840 0.0058859961 4.387299e-02 9.815196e-02 17 81539754 81539884 131 - 0.712 0.385 -1.539
ENSG00000185504 E002 1.4361079 0.0144077741 3.657907e-02 8.467079e-02 17 81539885 81539885 1 - 0.598 0.234 -2.055
ENSG00000185504 E003 1.4361079 0.0144077741 3.657907e-02 8.467079e-02 17 81539886 81539890 5 - 0.598 0.234 -2.055
ENSG00000185504 E004 475.2358326 0.0025874518 4.206177e-09 5.551398e-08 17 81539891 81540272 382 - 2.411 2.613 0.673
ENSG00000185504 E005 270.9792527 0.0027891890 7.492819e-05 4.038729e-04 17 81540273 81540312 40 - 2.201 2.364 0.546
ENSG00000185504 E006 1094.2177073 0.0028229599 1.955742e-04 9.449842e-04 17 81540313 81540950 638 - 2.851 2.961 0.368
ENSG00000185504 E007 330.8684653 0.0012819204 3.437135e-02 8.047096e-02 17 81541309 81541395 87 - 2.358 2.434 0.254
ENSG00000185504 E008 354.7995982 0.0001447187 1.085163e-02 3.080878e-02 17 81544004 81544120 117 - 2.389 2.461 0.240
ENSG00000185504 E009 317.4163944 0.0036356083 2.762547e-01 4.156919e-01 17 81545746 81545882 137 - 2.354 2.413 0.198
ENSG00000185504 E010 2.3939094 0.0063052905 9.834246e-02 1.879988e-01 17 81546401 81546540 140 - 0.659 0.386 -1.316
ENSG00000185504 E011 523.5185823 0.0001663362 5.258514e-01 6.591741e-01 17 81546909 81547322 414 - 2.596 2.621 0.081
ENSG00000185504 E012 473.5142364 0.0002364167 4.836401e-02 1.062691e-01 17 81547323 81547678 356 - 2.594 2.567 -0.090
ENSG00000185504 E013 113.3875453 0.0012331343 4.314918e-12 9.534656e-11 17 81547679 81548498 820 - 2.149 1.889 -0.874
ENSG00000185504 E014 138.7661305 0.0002437606 3.219621e-02 7.622916e-02 17 81549206 81549253 48 - 2.093 2.028 -0.217
ENSG00000185504 E015 233.9962372 0.0005287297 3.056676e-02 7.308178e-02 17 81549254 81549362 109 - 2.307 2.257 -0.168
ENSG00000185504 E016 181.5449067 0.0019930874 4.458956e-02 9.944504e-02 17 81550248 81550291 44 - 2.207 2.147 -0.202
ENSG00000185504 E017 597.1745076 0.0013772748 3.603832e-03 1.202126e-02 17 81550292 81550796 505 - 2.717 2.665 -0.172
ENSG00000185504 E018 386.3082282 0.0009888352 3.088731e-06 2.304106e-05 17 81550797 81551203 407 - 2.567 2.465 -0.339
ENSG00000185504 E019 103.4725124 0.0038191315 8.258205e-06 5.591666e-05 17 81551732 81551927 196 - 2.067 1.867 -0.671
ENSG00000185504 E020 128.4310182 0.0039406548 8.063938e-03 2.394208e-02 17 81551928 81552052 125 - 2.093 1.986 -0.359
ENSG00000185504 E021 66.2333200 0.0141005240 6.152763e-03 1.901381e-02 17 81552166 81552193 28 - 1.866 1.682 -0.622
ENSG00000185504 E022 79.7240669 0.0278832504 9.543534e-03 2.764381e-02 17 81552194 81552401 208 - 1.966 1.756 -0.710
ENSG00000185504 E023 5.6305322 0.0031387762 3.694908e-01 5.139082e-01 17 81553074 81553127 54 - 0.598 0.752 0.648
ENSG00000185504 E024 0.2903454 0.3356112985 5.657032e-02   17 81553445 81553961 517 - 0.339 0.000 -12.150