ENSG00000185480

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327680 ENSG00000185480 HEK293_OSMI2_2hA HEK293_TMG_2hB PARPBP protein_coding protein_coding 11.51181 3.487059 17.03778 0.2612966 0.6922444 2.28537 4.0660078 0.46865491 8.1381850 0.18392730 0.04797344 4.0894209 0.29141667 0.13233333 0.47943333 0.347100000 1.561766e-04 3.011625e-14 FALSE TRUE
ENST00000392909 ENSG00000185480 HEK293_OSMI2_2hA HEK293_TMG_2hB PARPBP protein_coding nonsense_mediated_decay 11.51181 3.487059 17.03778 0.2612966 0.6922444 2.28537 0.3757032 0.09619245 1.4279258 0.04816924 0.32634607 3.7592361 0.03997500 0.02590000 0.08490000 0.059000000 1.708112e-01 3.011625e-14 TRUE TRUE
ENST00000392914 ENSG00000185480 HEK293_OSMI2_2hA HEK293_TMG_2hB PARPBP protein_coding retained_intron 11.51181 3.487059 17.03778 0.2612966 0.6922444 2.28537 0.2805711 0.23407625 0.0000000 0.14433558 0.00000000 -4.6092600 0.02912917 0.06980000 0.00000000 -0.069800000 5.410243e-02 3.011625e-14 FALSE TRUE
ENST00000535811 ENSG00000185480 HEK293_OSMI2_2hA HEK293_TMG_2hB PARPBP protein_coding processed_transcript 11.51181 3.487059 17.03778 0.2612966 0.6922444 2.28537 0.4412406 1.10238941 0.0000000 0.36629135 0.00000000 -6.7975181 0.11272083 0.30610000 0.00000000 -0.306100000 3.011625e-14 3.011625e-14 FALSE FALSE
ENST00000537257 ENSG00000185480 HEK293_OSMI2_2hA HEK293_TMG_2hB PARPBP protein_coding protein_coding 11.51181 3.487059 17.03778 0.2612966 0.6922444 2.28537 0.1876329 0.26859447 0.2320782 0.07851675 0.05158434 -0.2026937 0.02713750 0.08020000 0.01366667 -0.066533333 5.906846e-03 3.011625e-14 FALSE TRUE
ENST00000541668 ENSG00000185480 HEK293_OSMI2_2hA HEK293_TMG_2hB PARPBP protein_coding processed_transcript 11.51181 3.487059 17.03778 0.2612966 0.6922444 2.28537 1.1847065 0.66746055 1.6578286 0.08147607 0.38215202 1.2997622 0.14830000 0.19076667 0.09580000 -0.094966667 1.116511e-01 3.011625e-14 FALSE TRUE
MSTRG.7879.10 ENSG00000185480 HEK293_OSMI2_2hA HEK293_TMG_2hB PARPBP protein_coding   11.51181 3.487059 17.03778 0.2612966 0.6922444 2.28537 1.2857148 0.14379226 0.8071147 0.08651643 0.20917010 2.4095557 0.07659167 0.04553333 0.04840000 0.002866667 8.757095e-01 3.011625e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185480 E001 0.0000000       12 102120125 102120156 32 +      
ENSG00000185480 E002 0.4720498 0.2366220313 3.441494e-01 4.881996e-01 12 102120157 102120182 26 + 0.097 0.266 1.756
ENSG00000185480 E003 0.4720498 0.2366220313 3.441494e-01 4.881996e-01 12 102120183 102120184 2 + 0.097 0.266 1.757
ENSG00000185480 E004 0.9096442 0.2425571470 7.415794e-01 8.306972e-01 12 102120185 102120194 10 + 0.211 0.266 0.438
ENSG00000185480 E005 4.2894518 0.0902434677 3.823411e-01 5.265757e-01 12 102120195 102120203 9 + 0.641 0.428 -1.006
ENSG00000185480 E006 18.9453065 0.0012134044 8.950427e-01 9.369321e-01 12 102120204 102120244 41 + 1.163 1.186 0.081
ENSG00000185480 E007 20.1705533 0.0018821174 9.110740e-01 9.475200e-01 12 102120245 102120246 2 + 1.189 1.209 0.073
ENSG00000185480 E008 31.6721408 0.0006846844 5.916992e-01 7.144183e-01 12 102120247 102120286 40 + 1.382 1.344 -0.131
ENSG00000185480 E009 0.9651910 0.0129837210 2.087049e-01 3.369482e-01 12 102120383 102120491 109 + 0.177 0.429 1.749
ENSG00000185480 E010 44.3922495 0.0005538349 8.094739e-01 8.790168e-01 12 102123886 102123987 102 + 1.517 1.508 -0.030
ENSG00000185480 E011 42.5157811 0.0005509653 3.842261e-01 5.283900e-01 12 102123988 102124041 54 + 1.505 1.447 -0.199
ENSG00000185480 E012 22.6148995 0.0008567323 8.857369e-02 1.729420e-01 12 102148230 102148234 5 + 1.257 1.078 -0.638
ENSG00000185480 E013 76.0187183 0.0003296981 2.651463e-01 4.031717e-01 12 102148235 102148463 229 + 1.753 1.698 -0.184
ENSG00000185480 E014 4.5328737 0.0042875343 2.724380e-09 3.730579e-08 12 102148464 102149007 544 + 0.353 1.186 3.514
ENSG00000185480 E015 2.4442514 0.0060908133 9.342080e-01 9.625331e-01 12 102150264 102150371 108 + 0.441 0.429 -0.059
ENSG00000185480 E016 9.4208765 0.0830942347 1.139419e-01 2.112645e-01 12 102151570 102151800 231 + 0.824 1.117 1.093
ENSG00000185480 E017 6.4909594 0.1100897293 1.604799e-01 2.757683e-01 12 102151801 102152012 212 + 0.679 0.988 1.208
ENSG00000185480 E018 50.2808748 0.0005104380 1.822062e-01 3.039582e-01 12 102153869 102153976 108 + 1.583 1.497 -0.296
ENSG00000185480 E019 2.0995026 0.0079693589 3.346803e-01 4.784223e-01 12 102153977 102153989 13 + 0.353 0.548 1.014
ENSG00000185480 E020 15.6646346 0.0013106960 2.167560e-03 7.742769e-03 12 102154827 102154996 170 + 1.028 1.344 1.125
ENSG00000185480 E021 17.1381427 0.0226330595 5.626987e-11 1.035268e-09 12 102154997 102155280 284 + 0.918 1.624 2.494
ENSG00000185480 E022 37.9165891 0.0009894400 2.104212e-05 1.298393e-04 12 102164438 102164538 101 + 1.493 1.078 -1.457
ENSG00000185480 E023 35.9465765 0.0006207645 1.740324e-04 8.527805e-04 12 102164539 102164608 70 + 1.468 1.108 -1.264
ENSG00000185480 E024 61.3670143 0.0013383470 7.680658e-03 2.297902e-02 12 102165729 102165883 155 + 1.675 1.497 -0.607
ENSG00000185480 E025 42.9251798 0.0037432717 9.900159e-03 2.851631e-02 12 102175483 102175666 184 + 1.528 1.310 -0.754
ENSG00000185480 E026 43.7207762 0.0484418389 5.777484e-02 1.228135e-01 12 102178592 102178770 179 + 1.536 1.304 -0.801
ENSG00000185480 E027 44.6215658 0.0015855081 5.656003e-01 6.926614e-01 12 102182549 102182627 79 + 1.520 1.485 -0.121
ENSG00000185480 E028 45.3361158 0.0022147379 7.385957e-04 3.037748e-03 12 102195312 102195447 136 + 1.558 1.272 -0.988
ENSG00000185480 E029 58.2851087 0.0013002551 1.767671e-02 4.643940e-02 12 102195951 102196087 137 + 1.655 1.496 -0.541
ENSG00000185480 E030 97.2127961 0.0007784654 4.937944e-01 6.308060e-01 12 102196088 102196548 461 + 1.855 1.830 -0.085
ENSG00000185480 E031 157.1842051 0.0008021709 1.407058e-14 4.538788e-13 12 102196549 102197520 972 + 2.007 2.272 0.889