ENSG00000185344

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330342 ENSG00000185344 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V0A2 protein_coding protein_coding 16.10862 8.056234 19.43372 0.8473773 0.5585785 1.269337 7.9342546 3.8933552 11.0428372 0.25917194 0.25545411 1.5016301 0.48515833 0.4914 0.56903333 0.07763333 0.547644419 0.008880266 FALSE TRUE
ENST00000536426 ENSG00000185344 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V0A2 protein_coding processed_transcript 16.10862 8.056234 19.43372 0.8473773 0.5585785 1.269337 1.2518989 0.0000000 0.4831164 0.00000000 0.48311639 5.6238563 0.05077083 0.0000 0.02370000 0.02370000 0.958679017 0.008880266 FALSE FALSE
ENST00000540368 ENSG00000185344 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V0A2 protein_coding retained_intron 16.10862 8.056234 19.43372 0.8473773 0.5585785 1.269337 3.5461963 1.1728714 4.3028137 0.11379403 0.10283452 1.8663362 0.21249583 0.1459 0.22146667 0.07556667 0.008880266 0.008880266 FALSE TRUE
ENST00000543687 ENSG00000185344 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V0A2 protein_coding retained_intron 16.10862 8.056234 19.43372 0.8473773 0.5585785 1.269337 1.3865573 1.6009944 1.3444789 0.60441537 0.07424459 -0.2502136 0.11180000 0.1888 0.06906667 -0.11973333 0.072109379 0.008880266 FALSE FALSE
ENST00000675260 ENSG00000185344 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V0A2 protein_coding retained_intron 16.10862 8.056234 19.43372 0.8473773 0.5585785 1.269337 0.9023285 0.4606923 1.1200066 0.06852599 0.05799498 1.2634752 0.06001250 0.0599 0.05790000 -0.00200000 1.000000000 0.008880266 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185344 E001 0.1451727 0.0435834810 1.000000e+00   12 123712353 123712355 3 + 0.080 0.000 -10.978
ENSG00000185344 E002 11.9983354 0.2566570934 2.108595e-01 3.395685e-01 12 123712356 123712446 91 + 1.136 0.938 -0.727
ENSG00000185344 E003 23.3081967 0.0729906044 4.596510e-02 1.019678e-01 12 123712447 123712534 88 + 1.417 1.174 -0.850
ENSG00000185344 E004 22.7815269 0.0058849098 1.405278e-02 3.834392e-02 12 123712535 123712582 48 + 1.389 1.226 -0.570
ENSG00000185344 E005 47.1591501 0.0005234052 9.860930e-05 5.153587e-04 12 123712583 123712682 100 + 1.699 1.534 -0.563
ENSG00000185344 E006 51.6196600 0.0130274286 2.359518e-03 8.336822e-03 12 123718623 123718701 79 + 1.743 1.557 -0.632
ENSG00000185344 E007 0.0000000       12 123718702 123719576 875 +      
ENSG00000185344 E008 75.4766632 0.0020919132 1.871762e-05 1.168676e-04 12 123722351 123722448 98 + 1.896 1.738 -0.533
ENSG00000185344 E009 0.4031496 0.0278762167 5.598069e-02 1.196671e-01 12 123723210 123724653 1444 + 0.000 0.313 14.480
ENSG00000185344 E010 103.6881323 0.0003392827 2.700840e-07 2.522617e-06 12 123724654 123724791 138 + 2.027 1.886 -0.476
ENSG00000185344 E011 81.2602359 0.0003563191 2.656358e-08 3.022457e-07 12 123726197 123726285 89 + 1.936 1.747 -0.638
ENSG00000185344 E012 50.3952872 0.0004489358 1.206990e-06 9.851812e-06 12 123727783 123727821 39 + 1.738 1.520 -0.740
ENSG00000185344 E013 69.8691751 0.0099363674 3.385352e-03 1.139500e-02 12 123727822 123727909 88 + 1.860 1.714 -0.493
ENSG00000185344 E014 0.6287620 0.0172671820 4.224234e-01 5.655647e-01 12 123730642 123733925 3284 + 0.147 0.312 1.389
ENSG00000185344 E015 77.4727744 0.0027256230 1.375169e-03 5.225903e-03 12 123733926 123734008 83 + 1.894 1.789 -0.353
ENSG00000185344 E016 88.9181411 0.0044301288 4.456810e-03 1.442065e-02 12 123735531 123735624 94 + 1.950 1.858 -0.309
ENSG00000185344 E017 0.2214452 0.0449249453 2.097476e-01   12 123735893 123736540 648 + 0.000 0.184 13.481
ENSG00000185344 E018 117.0705617 0.0003050242 9.734548e-04 3.868316e-03 12 123737059 123737271 213 + 2.058 2.000 -0.195
ENSG00000185344 E019 1.9927489 0.0080156667 8.818749e-02 1.723582e-01 12 123737272 123737644 373 + 0.344 0.670 1.609
ENSG00000185344 E020 0.3030308 0.3807346756 6.652636e-01   12 123738959 123739013 55 + 0.147 0.000 -11.978
ENSG00000185344 E021 0.1515154 0.0433247180 1.000000e+00   12 123742029 123742093 65 + 0.080 0.000 -10.971
ENSG00000185344 E022 0.5954526 0.0183346618 1.878919e-01 3.110847e-01 12 123743472 123743784 313 + 0.256 0.000 -12.971
ENSG00000185344 E023 88.3900027 0.0024120721 1.544185e-01 2.676449e-01 12 123743785 123743935 151 + 1.921 1.912 -0.030
ENSG00000185344 E024 97.0459735 0.0003166898 4.093754e-02 9.276684e-02 12 123744201 123744337 137 + 1.966 1.947 -0.065
ENSG00000185344 E025 117.1511388 0.0006505713 3.287517e-03 1.111328e-02 12 123744597 123744784 188 + 2.056 2.007 -0.164
ENSG00000185344 E026 86.5392207 0.0004845634 1.689176e-03 6.248231e-03 12 123744882 123744972 91 + 1.934 1.861 -0.244
ENSG00000185344 E027 99.5655909 0.0037449993 1.809938e-01 3.024654e-01 12 123747607 123747725 119 + 1.974 1.967 -0.025
ENSG00000185344 E028 0.0000000       12 123747726 123747726 1 +      
ENSG00000185344 E029 125.0037475 0.0004644948 9.176904e-01 9.519865e-01 12 123748575 123748785 211 + 2.049 2.112 0.212
ENSG00000185344 E030 2.3657862 0.0065852534 7.461835e-01 8.340220e-01 12 123749996 123751109 1114 + 0.507 0.492 -0.069
ENSG00000185344 E031 85.7839545 0.0003447592 8.373529e-02 1.653919e-01 12 123751110 123751229 120 + 1.864 1.993 0.433
ENSG00000185344 E032 105.6662310 0.0002958305 2.203986e-02 5.576178e-02 12 123752283 123752402 120 + 1.949 2.091 0.476
ENSG00000185344 E033 19.5675593 0.0009837917 5.036210e-01 6.395947e-01 12 123752403 123753116 714 + 1.243 1.354 0.390
ENSG00000185344 E034 15.1175939 0.0555127561 4.146311e-01 5.580385e-01 12 123753991 123754419 429 + 1.115 1.274 0.566
ENSG00000185344 E035 105.8289989 0.0004311056 2.414194e-02 6.010406e-02 12 123754420 123754537 118 + 1.951 2.092 0.475
ENSG00000185344 E036 49.2546110 0.0004865987 7.181341e-02 1.463641e-01 12 123754538 123755441 904 + 1.621 1.774 0.518
ENSG00000185344 E037 29.1681615 0.0014577013 3.005463e-05 1.788185e-04 12 123756327 123756814 488 + 1.316 1.650 1.150
ENSG00000185344 E038 136.0006943 0.0019086961 7.622184e-03 2.283004e-02 12 123756815 123756986 172 + 2.052 2.211 0.531
ENSG00000185344 E039 889.2449082 0.0153244396 1.995825e-03 7.213230e-03 12 123757927 123761755 3829 + 2.846 3.043 0.656