ENSG00000185252

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000400451 ENSG00000185252 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF74 protein_coding protein_coding 24.7705 37.61887 16.31511 1.186006 0.1457449 -1.204747 8.937314 11.9242824 6.449160 1.54009366 0.5433770 -0.8856933 0.35981250 0.31503333 0.39506667 0.08003333 4.121340e-01 4.523939e-06 FALSE  
ENST00000403682 ENSG00000185252 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF74 protein_coding protein_coding 24.7705 37.61887 16.31511 1.186006 0.1457449 -1.204747 10.630529 17.0787804 6.175952 1.36116552 0.6529115 -1.4659819 0.41909167 0.45313333 0.37870000 -0.07443333 5.134844e-01 4.523939e-06 FALSE  
ENST00000476678 ENSG00000185252 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF74 protein_coding retained_intron 24.7705 37.61887 16.31511 1.186006 0.1457449 -1.204747 1.552534 1.4017358 1.081400 0.12016504 0.1001079 -0.3712901 0.07009167 0.03750000 0.06623333 0.02873333 4.587489e-02 4.523939e-06 FALSE  
ENST00000493734 ENSG00000185252 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF74 protein_coding retained_intron 24.7705 37.61887 16.31511 1.186006 0.1457449 -1.204747 1.167958 0.9415552 1.275007 0.08335316 0.1052102 0.4334173 0.05416667 0.02513333 0.07830000 0.05316667 4.523939e-06 4.523939e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185252 E001 0.4031496 0.0246458441 5.645866e-01 6.918450e-01 22 20394115 20394127 13 + 0.000 0.159 8.868
ENSG00000185252 E002 2.8420984 0.0360885569 2.607781e-01 3.983714e-01 22 20394128 20394150 23 + 0.640 0.478 -0.743
ENSG00000185252 E003 4.5976053 0.0434625181 8.866016e-01 9.314878e-01 22 20394151 20394160 10 + 0.685 0.701 0.067
ENSG00000185252 E004 27.6554868 0.0092488040 8.134354e-01 8.817047e-01 22 20394161 20394187 27 + 1.354 1.421 0.231
ENSG00000185252 E005 27.4340416 0.0092014137 8.482209e-01 9.057503e-01 22 20394188 20394188 1 + 1.354 1.417 0.218
ENSG00000185252 E006 39.1304731 0.0059781459 3.916706e-01 5.356029e-01 22 20394189 20394201 13 + 1.562 1.548 -0.048
ENSG00000185252 E007 118.0650407 0.0050291054 2.222523e-02 5.614228e-02 22 20394202 20394334 133 + 2.067 2.006 -0.206
ENSG00000185252 E008 103.2387416 0.0004763909 6.695769e-04 2.787040e-03 22 20394335 20394402 68 + 2.024 1.941 -0.277
ENSG00000185252 E009 162.5297237 0.0029268884 2.206809e-05 1.354434e-04 22 20394403 20394562 160 + 2.241 2.126 -0.384
ENSG00000185252 E010 136.4688399 0.0009576359 4.744103e-03 1.521652e-02 22 20394563 20394628 66 + 2.122 2.070 -0.176
ENSG00000185252 E011 127.7504289 0.0025406436 4.805872e-02 1.057332e-01 22 20394629 20394662 34 + 2.081 2.047 -0.113
ENSG00000185252 E012 27.3191261 0.0007467793 1.720808e-11 3.446185e-10 22 20394663 20395332 670 + 1.655 1.255 -1.378
ENSG00000185252 E013 57.2141163 0.0128844948 4.195374e-03 1.369237e-02 22 20395333 20395346 14 + 1.827 1.663 -0.556
ENSG00000185252 E014 86.6650272 0.0020367873 1.934724e-05 1.204336e-04 22 20395347 20395418 72 + 1.991 1.847 -0.485
ENSG00000185252 E015 3.8760137 0.0041951715 9.011983e-02 1.753113e-01 22 20399511 20399594 84 + 0.798 0.587 -0.881
ENSG00000185252 E016 13.8306588 0.0012621754 9.355439e-01 9.634280e-01 22 20399595 20399690 96 + 1.098 1.133 0.127
ENSG00000185252 E017 34.3133641 0.0087241584 1.756212e-03 6.459742e-03 22 20399691 20400631 941 + 1.631 1.444 -0.642
ENSG00000185252 E018 246.4613573 0.0005146987 1.392541e-02 3.805667e-02 22 20400632 20400758 127 + 2.354 2.337 -0.057
ENSG00000185252 E019 30.4815077 0.0063361702 2.973058e-04 1.368774e-03 22 20400759 20401276 518 + 1.601 1.379 -0.761
ENSG00000185252 E020 213.7623875 0.0007235037 1.880102e-02 4.889689e-02 22 20401277 20401372 96 + 2.294 2.274 -0.067
ENSG00000185252 E021 877.4418011 0.0006626063 5.505856e-01 6.801966e-01 22 20405377 20406435 1059 + 2.849 2.907 0.193
ENSG00000185252 E022 230.8146357 0.0006081517 5.501440e-03 1.729127e-02 22 20406436 20406519 84 + 2.217 2.343 0.423
ENSG00000185252 E023 1715.9339822 0.0050430326 4.850554e-05 2.742071e-04 22 20406520 20408461 1942 + 3.076 3.221 0.483